האם מדכאי חומציות קיבה מעלים את הסיכון לפריטוניטיס אנטרית בקרב מטופלים העוברים דיאליזה פריטוניאלית?
האם יש צורך בהתאמת מינונים של Ciprofloxacin עבור מטופלים שעברו ניתוח מעקף קיבה?
שלושה ניסויים בדקו השפעות של גורמים שונים על הפרמקוקינטיקה של Ivosidenib
תסמונת קשיחות רפה של הפין - תסמונת אורולוגית חדשה?
האם מדידות לחץ דם מחוץ למרפאה יעילות להערכת הסיכון למחלות קרדיווסקולריות?
האם אמבוליזציה של עורק הערמונית עולה לבית החולים יותר מכריתת ערמונית?
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BCL-2 Inhibitor. Venetoclax 10, 50, 100 mg. F.C. TABS.: Dosage should be ajust. individ. See lit.
Tmt. of pts. with Chron. Lymphoc. Leukem./Small Lymphoc. Lymphoma with or without 17p deletion, who have received at least one prior ther.
Acute Myeloid Leukem.: in comb. with a hypomethylating agent/comb. with low dose cytarabine is indicated for newly diagnosed pts. with AML who are ineligible for intensive chemother.
C/I: Concom. use with strong CYP3A inhib. at init. and during ramp-up phase is contraind. in pts. with CLL/SLL due to the potent. for incr. risk of tumor lysis syndr. Concom. use with St. John’s wort.
Antihistamine. Dimethindene Maleate 1 mg/ml. ORAL DROPS: 20 ml x 1 mg/ml (0.05
mg/drop). 20-40 drops 3 x dly. Child:
about 0.1 mg/kg bdy wt. 1 mth-1 yr:
3-10 drops 3 x dly, 1-3 yrs: 10-15 drops
3 x dly; 3-12 yrs: 15-20 drops 3x dly.
Prurit., allerg. conds.
BCL-2 Inhibitor. Venetoclax 10, 50, 100 mg. F.C. TABS.: Dosage should be ajust. individ. See lit.
Tmt. of pts. with Chron. Lymphoc. Leukem./Small Lymphoc. Lymphoma with or without 17p deletion, who have received at least one prior ther.
Acute Myeloid Leukem.: in comb. with a hypomethylating agent/comb. with low dose cytarabine is indicated for newly diagnosed pts. with AML who are ineligible for intensive chemother.
C/I: Concom. use with strong CYP3A inhib. at init. and during ramp-up phase is contraind. in pts. with CLL/SLL due to the potent. for incr. risk of tumor lysis syndr. Concom. use with St. John’s wort.
Progestogen. Dydrogesterone 10 mg. TABS: 20. In comb. with cont. estrogen
ther: 1 tab dly for 14 consec. days/28
day cycle. In comb. with cyclical
estrogen ther: 1 tab dly dur. last 12-14
days estrogen ther. If inad.
progestational response: 20 mg to be
given.
Progeston supplement.
C/I: Hypersens.
Antibacterial, Antifungal, Corticosteroid. Gramicidin 0.25 mg/g, Neomycin Sulphate 2.5 mg/g, Nystatin 100000 IU/g, Triamcinolone 1 mg/g. CREAM: 5, 15 g. Apply 2-3 x dly.
See lit.
Allerg. and infect. dermatit., eczema,
cutan. candidiasis, anogenital prurit.
C/I: T.B., herpes simplex, vaccinia,
varicella, lesions not suscept. to nystatin.
Antibacterial, Antifungal, Corticosteroid. Gramicidin 0.25 mg/g, Neomycin Sulphate 2.5 mg/g, Nystatin 100000 IU/g, Triamcinolone 1 mg/g. OINT.: 5, 15 g. Apply 2-3 x dly.
See lit.
Allerg. and infect. dermatit., eczema,
cutan. candidiasis, anogenital prurit.
C/I: T.B., herpes simplex, vaccinia,
varicella, lesions not suscept. to nystatin.
Cephalosporins. Cephalexin (as monohydrate) 500 mg. CAPS: 10, 20 x 500 mg. 1-4 g per
day in div. doses. Child: 25-50 mg/kg
bdy. wt. dly. in div. doses.
Infects. due to cephalexin suscept. organ.
C/I: Hypersens. to cephalexin. See lit.
Analgesic, Antipyretic, Opioid. Caffeine 50 mg, Codeine Phosphate 15 mg, Paracetamol 500 mg. CAPLETS: 12, 24. 1 caplet 3-4 x dly.
Pain, fever, cough with pain.
CCB, Local Anesthetic. Lidocaine HCl 1.5%, Nifedipine 0.3%. RECTAL CR.: 30g. Should be applied twice dly. for at least 3 wks. See lit.
Tmt. of anal fissures and proctolog. general. associate. with anal sphincter hypertonia.
C/I: Hypersens. to the active ingred., partic. to Lidocaine (& other local anesthet. with a similar amidic type structure). Presumed or ascertained preg. & lact.
5-α Reductase Inhibitor. Dutasteride 0.5 mg. SOFT CAPS.: 30. 1 tab. (0.5 mg) ×1/d.
Tmt. of moder. – sev. sympt. of BPH. Reduct. in the risk of acute urin. retent. (AUR) and surg. in pts. with moder. & severe sympt. of BPH.
C/I: Women & child. Pts. with known hypersens. to dutasteride, other 5- α reductase inhib. Pts. with sev. hep. impair.
Pyrimidine Synthesis Inhibitor. Teriflunomide 14 mg. F.C. TABS.: 28. 1 tab. (14 mg) ×1/d.
Tmt. of adult pts. with relaps. remitting forms of Multiple Sclerosis (MS) to reduce the frequen. of clinical relapses and to delay the progres. of physical disabil.
C/I: Hypersens. Preg., lact. Severe hep. impair. Immunologic disord. (e.g. AIDS). Bone marrow disord. (e.g.: anemia, leucopenia, thrombocytopenia). Pts. with severe infec. Pts. with renal impair. that require dialysis. Pts. with hypoproteinemia.
Antimycotic, Triazole Derivatives. Isavuconazole 200 mg. VIAL (pwdr. for concentrat. for sol. for infus.): 1×10ml. Load. dose: The recomm. load. dose is 1 vial after reconstit. & dilute. (equiv. to 200 mg of isavuconazole) every 8 hrs. for the first 48 hrs. (6 admin. in total).
Mainten. dose: The recom. mainten. dose is one vial after reconstit. and dilute. (equiv. to 200 mg of isavuconazole) once dly., starting 12- 24 hrs. after the last load. dose.
Durat. of therapy should be determ. by the clinical response.
For long-term tmt. beyond 6 mnths., the benefit-risk balance should be carefully considered.
Switch to oral isavuconazole: This drug is also available as hard caps. contain. 100 mg isavuconazole, equiv. to 186 mg isavuconazonium sulfate. See lit.
Indic. in adult. for the tmt. of: Invasive aspergillosis, mucormycosis in pts. for whom amphotericin B is inappropr.
Consideration should be given to official guidance on the appropr. use of antifung. agents.
C/I: Hypersens. Co-admin. with ketoconazole. Co-admin. with high-dose ritonavir (>200 mg every 12 hrs.).
Co-admin. with strong CYP3A4/5 induc. such as rifampicin, rifabutin, carbamazepine, long-act. barbiturates (e.g. phenobarbital), phenytoin and St. John’s wort or with moder. CYP3A4/5 induc. (e.g. efavirenz, nafcillin, etravirine). Pts. with familial short QT syndr.
NSAID. Etoricoxib 30, 60, 90, 120 mg. TABS.: 7,10,14,28,30×30 mg.
7,10,14,30×60,90, 120 mg. Osteoarthrit.: 30 mg ×1/d; can be incr. to a max. of 60 mg ×1/d, if necessary.
RA: 60 mg×1/d, can be incr. to a max. of 90 mg×1/d, if necessary.
Ankylos. spondylit.: 60 mg ×1/d, can be incr. to a max. of 90 mg ×1/d, if necessary.
Acute pain condit.: Etoricoxib should be used only for the acute painful period.
Gout: 120 mg×1/d, which should only be used for the acute painful period, limited to a max. of 8 d. of tmt.
Postoperat. dental surg. pain: 90 mg ×1/d, limited to a max. of 3 tmt. d.
30 mg tabs.: indic. for the symptom. relief of osteoarthritis (OA).
60 mg tabs.: indic. for the symptom. relief of OA, RA and ankylos. spondylitis.
90 mg tabs.: indic. for the symptom. relief of RA and ankylos. spondylitis. For the short-term tmt. of moder. pain assoc. with dental surg.
120 mg tabs.: indic. for the sympt. relief of the pain and signs of inflamm. assoc. with acute gouty arthritis.
C/I: Hypersens. Hypersens. to NSAIDs, includ. aspirin and COX-2 inhib.
Pts. with peptic ulcer, bleed. or intest. bleed.
Pts. with severe hep. dis. Pts. with a severe renal dis. Preg. Lact. Pts. under 16 yrs. of age. Pts. with IBD, Crohn’s dis., ulcerat. colitis. Pts. with uncontrolled hypertension. Pts. with HF (moder./severe). Pts. with ischem. heart dis./peripher. vasc. dis. (e.g. DVT). Pts. with any kind of stroke, (TIA). Pts. with history of MI.
Antiseptic. Povidone Iodine 2.5%. SPRAY: 30 g, 80 g. The dose is proportion. to the size of the area to be treated.
Applied once/multiple times dly. on the area to be treated until this is visibly covered with the golden-brown colour. povidone-iodine pwdr.
New-borns/infan. under 6 mnths.: may only be used in new-borns & infants up to the age of 6 mnths. See lit.
As antiseptic for prevent. & tmt. of infec. assoc, with burns, cuts and scrapes, and for prevent. tmt. of wounds at risk of infec., e.g. after placement of a suture for wound tmt. or after surg.
C/I: Hypersens. Hyperthyroidism/other manifesting thyroid dis. Dermatit. herpetiformis (Duhring’s dis.). Use in conjunct. with products contain. mercury.
Use in conjunct. with octenidine-based antiseptics. Before and after radioact. iodine therap. (until the tmt. is concluded). Before radioact. iodine scintigraphy for thyroid testing. Before radioact. iodine tmt. for thyroid canc.
Protease Inhibitors. Darunavir 800 mg. F.C. TABS.:30. 800 mg×1/d admin. every day at the same time, and always with 100 mg of ritonavir with food. See lit.
Indicated in co-admin.with 100 mg ritonavir and with other antiretrov. agents, for the tmt. of HIV-1infec. for pts. over 18 yrs. of age.
C/I: Hypersensitivity to active substance or to any of its excipients. Pts. under 18 yrs. old age. For pts. with hep. impair., addit. blood tests may be required.
