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הקורלציה בין רעילות קלינית רלוונטית של פזופאניב וסאניטיניב והשימוש ב- CYP3A4 חלש ומעכבי P-gp
מחיקה של הגן LSD1 מדכאת את נדידת תאי סרטן הקיבה על ידי רגולציה חיובית על חלבון מטרה חדש miR-142-5p target protein CD9
אורוקסילין A מדכא את ביטוי ACTN1 על מנת להפוך את הפיברובלסטים הקשורים לסרטן ללא פעילים וכן לרסן את הגרורות של סרטן השד
ההימצאות של גסטרופרזיס בחולי סוכרת ממוצא אירופאי ואפריקאי בארה"ב
Antihistamine. Dimethindene Maleate 1 mg/ml. ORAL DROPS: 20 ml x 1 mg/ml (0.05
mg/drop). 20-40 drops 3 x dly. Child:
about 0.1 mg/kg bdy wt. 1 mth-1 yr:
3-10 drops 3 x dly, 1-3 yrs: 10-15 drops
3 x dly; 3-12 yrs: 15-20 drops 3x dly.
Prurit., allerg. conds.
CCB, Local Anesthetic. Lidocaine HCl 1.5%, Nifedipine 0.3%. RECTAL CR.: 30g. Should be applied twice dly. for at least 3 wks. See lit.
Tmt. of anal fissures and proctolog. general. associate. with anal sphincter hypertonia.
C/I: Hypersens. to the active ingred., partic. to Lidocaine (& other local anesthet. with a similar amidic type structure). Presumed or ascertained preg. & lact.
Gilteritinib (as fumarate) 40 mg. F.C. TABS.: 84. Gilteritinib may be re init. in pts. follow. haematopoietic stem cell transplantation (HSCT). The recomm. start. dose is 120 mg gilteritinib (three 40 mg tabs.) once dly. Tmt. should cont.until the pt. is no longer clinical. benefiting from Gilteritinib or until unacceptab. toxicity occurs. Response may be delayed; therefore, cont. of tmt. at the prescribed dose for up to 6 months should be consid. to allow time for a clinical response. In the absence of a response (pt. did not achieve a CRc) after 4 wks. of tmt., the dose can be incr.to 200 mg (five 40 mg tabs.) once dly., if tolerated or clinically warranted. See lit. Indicated as monother. for the tmt. of adult pts. who have relapsed or refractory acute myeloid leukaemia (AML) with a FLT3 mutation.
C/I: Hypersens.
Cephalosporins. Cephalexin (as monohydrate) 500 mg. CAPS: 10, 20 x 500 mg. 1-4 g per
day in div. doses. Child: 25-50 mg/kg
bdy. wt. dly. in div. doses.
Infects. due to cephalexin suscept. organ.
C/I: Hypersens. to cephalexin. See lit.
Analgesic, Antipyretic, Opioid. Caffeine 50 mg, Codeine Phosphate 15 mg, Paracetamol 500 mg. CAPLETS: 12, 24. 1 capl. × 3-4 times/day. For severe pains - 2 capl. 3-4 times/day. Do not exceed a dosage of 8 capl. in 24 hrs. See lit.
For the relief of pain and coughs and for the reduction of fever accompanied by pain.
C/I: Hypersens. 1st & 3rd trim. of preg. Lact. Child. under 12 yrs. old. Adolesc. over 12 yrs. old and under 18 yrs. old after surg. remov. of their tonsils or adenoids. Concom. use with medic. contain. paracetamol /codeine. Pts. with respirat. depress. Pts. who are known as ultra-rapid metabolizer.
Other Anti-Dementia Drugs. Ginkgo Biloba 35-67:1. F.C. TABS.:15. Dementia: Adults≥ 18 yrs. 1 tab.×2 d.
Vertigo, adjuvant tinnitus tmt.: 1 tab.×1-2 d.
When taken once dly., the F. C. tab. should be taken in the morn. Dementia syndr.: Duration of the tmt. should last for at least 8 wks. See lit.
For the symptom. tmt. of mental losses due to organic brain syndr. within the framework of a general therap. concept for dementia syndr. having as major sympt.: Deficient memory, disturban. of concentr. , depress. mood, dizziness, tinnitus and headache. Vertigo of vascular and involutional origin.- Adjuvant tmt. in case of tinnitus of vascular and involutional origin. See lit.
C/I: Hypersens., preg.
Antibacterial, Antifungal, Corticosteroid. Gramicidin 0.25 mg/g, Neomycin Sulphate 2.5 mg/g, Nystatin 100000 IU/g, Triamcinolone 1 mg/g. CREAM: 5, 15 g. Apply 2-3 x dly.
See lit.
Allerg. and infect. dermatit., eczema,
cutan. candidiasis, anogenital prurit.
C/I: T.B., herpes simplex, vaccinia,
varicella, lesions not suscept. to nystatin.
Antihistamine. Oxomemazine 1.65 mg / 5 ml, Potassium Guaiacolsulphonate 33.3 mg / 5 ml, Sodium Benzoate 33.3 mg / 5 ml. SYR: 120 ml. 1-2 teasp. 2-3 x dly. Child:
1-4 yrs: 2-4 teasp. dly. Over 4 yrs: 3-5
teasp. dly.
Cough.
C/I: Preg. women 2 wks. before deliv. or
lact., if you are taking large doses of CNS
depressant.
Antivirals/HIV. Efavirenz 600 mg, Emtricitabine 200 mg, Tenofovir Disoproxil 245 mg. TABS.:30. Adult.: 1tab×1/d.
The tab. should be swallow. whole, on empty stomach not crushed, chewed or halved. See lit.
Indicated for use alone as a complete regimen or in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults.
C/I: Hypersens.
Pts. with severe liver disease.
Pts.with cardiac disorders e.g.: QT prolongation, Torsades de Pointes.
Corticosteroid/Beta 2-Agonist. Beclometasone Dipropionate 200mcg/metered dose, Formoterol Fumarate 6mcg/metered dose. INHALER. (Pressurised sol. for inhal).:1×120 actuation.
Adults 18 yrs. and above:
Two inhalations twice dly.
The max. dly. dose is 4 inhalat.
Foster 200/6 should be used as mainten. therapy only. A lower strength (Foster 100/6) is available for mainten. and reliever ther.
Indicated in the regular tmt. of asthma in adult. where use of a comb. product (inhaled corticosteroid and long-act. Β2-ag.) is appropriate:
Pts. not adequate. control. with inhaled corticosteroids and 'as needed' inhaled rapid-acting Β2-agonist.
Pts. already adequat. controlled on both inhaled corticosteroids and long-act. Β2-ag. C/I: Hypersens.
PARP inhibitor. Rucaparib 200mg, 250mg, 300mg. F. C. TAB.:60. The recom. dose is 600 mg (two 300 mg tabs.) taken orally twice dly. with / without food.
Cont. tmt. until dis. progress. or unaccept. toxic.
If a pt. misses a dose, instruct the pt. to take the next dose at its scheduled time. Vomited doses should not be replaced.
To manage adverse reactions, consider interruption of tmt. or dose reduct.
Recom.dose reductions: Starting Dose: 600 mg ×2/d(two 300 mg tab.).
1st Dose Reduct.: 500 mg ×2/d (two 250 mg tab.).
2nd Dose Reduct.: 400 mg ×2/d (two 200 mg tab.).
3rd Dose Reduct.: 300 mg ×2/d (one 300 mg tab.).
Indicated for the maint. tmt. of adult pts. with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemother.
Tmt. of adult pts. with deleterious BRCA mutat. (germline and/or somatic)-assoc. epithelial ovarian, fallopian tube, or prim. peritoneal cancer who have been treated with two or more chemotherapies.
C/I: Hypersens.
Monoclonal Antibody. Trastuzumab 420 mg. VIALS (420 mg of lyophilised powder & 20 ml of BWFI).: 1+1
Metast. Breast Canc.
Wkly. schedule: The recom. init. load. dose is 4 mg/kg bdy. wt. The recom. wkly. maint. dose of trastuzumab is 2 mg/kg bdy. wt., begin. one wk. after the load. dose.
Early Breast Canc.:
Three-wkly. and wkly. schedule: As a three-wkly. regimen the recom. init. load. dose is 8 mg/kg bdy. wt. The recom.
maint. dose at three-wkly. intervals is 6 mg/kg bdy. wt., begin. three wks. after the load. dose. As a wkly. regimen (initial load. dose of 4 mg/kg follow. by 2 mg/kg every wk.) concomit. with paclitaxel follow. chemother. with doxorubicin & cyclophosphamide.
Metast. Gastric Canc. Three-wkly. schedule: The recom. init. load. dose is 8 mg/kg bdy. wt. The recom. maint. dose at three-wkly. intervals is 6 mg/kg bdy. wt., begin. three wks. after the load. dose.
Indicated for the tmt. of pts. with metast. breast canc. who have tumours that overexpress HER2;
1. As a single agent, for the tmt. of those pts. who have received one or more chemother. regim. for their metast. dis.
2. In comb. with Paclitaxel or Docetaxel for the tmt. of those pts. who have not received chemother. for their metast. dis.
3. In comb. with an aromatase inhib. for the tmt. of postmenop. pt. with hormone-receptor posit. metast. breast canc.
Indicated to treat pts. with HER2 positive early breast canc. follow. surg. and chemother. (neoadjuvant or adjuvant) either alone or in comb. with chemother. exclud. anthracyclines.
This drug should only be used in pts. whose tumours have either HER2 overexpression or HER2 gene amplification as determin. by an accurate and validated assay. See lit.
HER2 Metastatic Gastric Cancer (MGC)
In comb. with capecitabine or 5-fluorouracil and cisplatin is indicated for the tmt. of pts. with HER2 positive metast. adenocarcinoma of the stomach or gastro-esophageal junct. who have not received prior anti-cancer tmt. for their metast. dis.
This drug should only be used in pts. with metast. gastr. cancer whose tumours have HER2 overexpres. defined by IHC2+ and a confirmat. FISH+ result, or IHC 3+, as determin. by an accurate and validated assay See Lit.
C/I: Hypersens. Hypersens. murine proteins. Severe dyspnoea at rest due to complications of advanced malig.or requir. supplement. oxygen ther.
See Lit.
Second generation antihistamine. Rupatadine (as fumarate) 10mg. TABS.:30. Adult. & adolesc. (over 12 yrs. of age): 10 mg (one tab.) ×1/d, with / without food. Elderly: should be used with caution. See lit.Ped. Pts.: Rupatadine not indicat. for child. <12 yrs.
Symptomatic tmt. of allergic rhinitis and urticaria in adult. & adolesc. (over 12 yrs. of age).
C/I: Hypersens.
Iron supplement. Folic Acid 400 mcg, Iron(as Hydroxide Polymaltose Complex) 100 mg. TAB.:30. Adult. & child. over 12 yrs.: Prevent. of anemia: 1 tab.×1/d. Tmt. of anemia: 3 tabs. a day at once or in divided doses. The tabs. should be taken during / after meal, before the admin. it may be mixed with vegetable/fruit juices. The tabs. can be chewed or swollen with small amount of water. Please refer to the license holder for further details. Prevent. & tmt. of anemia caused by iron and folic acid defic. includ. anemia of preg. and lact. C/I: Hypersens. Pts. with iron metabolism disord. (accumulation / utilization of iron). Pts. with other form of anemia rather than iron defic. anemia
