מה הן הסיבות לתמותה של מטופלים עם לימפומה פוליקולרית בעידן הטיפול עם Rituximab?
הפוטנציאל הטיפולי לפסיכדלים במגוון רחב של הפרעות נוירופסיכיאטריות
כמה מהמטופלים שעברו ניתוח לתיקון היפוספדיאס פרוקסימלי זקוקים לניתוח חוזר?
הקשר בין תחזיות לחצי דם בתחילת החיים לנזק כלייתי תת-קליני באמצע החיים
אפידמיולוגיה של התפרצויות מחלות מנינגוקליות בארה"ב ב-2013-2009
Advanced Therapy. Darvadstrocel 30 million cells/vial. VIAL(suspens. for inj): 1×30 million cells. A single dose of Alofisel consists of 120 million cells distribut. in 4 vial. Each vial contains 30 million cells in 6 mL of susp. The full content of the 4 vial. must be admin.for the tmt. of up to two intern. openings and up to three exter. openings. This means that with a dose of 120 million cells it is possible to treat up to three fistula tracts that open to the perianal area. There is currently limited exper. with the efficacy or safety of repeat admin. of this drug.
Tmt. of complex perianal fistulas in adult pts. with non-active/mildly active luminal Crohn’s dis., when fistulas have shown an inadeq. response to at least one convention. or biologic ther. The durg should be used after conditioning of fistula.
C/I: Hypersens. to the active subst. or to excipients.
5-α Reductase Inhibitor. Dutasteride 0.5 mg. SOFT CAPS.: 10, 30×0.5mg. 1 cap. (0.5 mg) once a day.
Tmt. of moder. –sev. sympt. of BPH.
Reduct. in the risk of acute urinary retent.(AUR) and surg. in pts. with moder.- sev. sympt. of BPH.
C/I: Hypersens.to other 5-alpha-reductase inhib.or to any of drug's excip.
Pts. with severe hepat. dis.
Female pts., child. or adolesc.
NSAID. Flurbiprofen 8.75 mg. LOZEN.: 16. Adults,elderl. and child.>12 yrs.: 1 lozen. sucked/dissolv. slow. in the mouth every 3 - 6 hrs. as require. Max. 5 lozen. in a 24 hrs. period. This product should be used for a max. of 3 d.
Child.: Not indic. for child. under 12 yrs. See lit.
For the short term relief of sympt. of sore throat such as throat pain and soreness in adult. & over the age of 12 yrs. child.
C/I: Hypersens. Pts. who have previous. shown hypersens. react. (e.g. asthma, bronchospasm, rhinitis, angioedema, or urticaria) in response to acetylsalicylic a. or other NSAIDs. Active or hist. of recur. peptic ulcer/haemorrhage (two or more distinct episodes of proven ulcerat.) and intest. ulcerat. History of GI bleed. or perforat., severe colitis, haemorrhagic or haematopoietic disord. related to previous NSAID ther. Last trim. of preg. Severe card. fail., severe ren./ hep. fail.
Herbal Medicinal Product. Agni Casti Fructus Dry Extract (7-11:1) 4 mg, Ethanol 70% v/v. F.C TABS: 30. 1 film-coated tablet once dly. See lit.
Premenstrual synd., mastodynia.
C/I: Hypersens.
Protein Kinase Inhibitor. Brigatinib 30 mg, 90 mg. F.C. TABS.: 30. The recom. dose regimen for is: 90 mg×1/d for the first 7 days;
If 90 mg is tolerat. during the first 7 d, incr. the dose to 180 mg ×1/d.
Admin. will cont. until dis. progres. or unaccept. toxicity.
If Brigatinib is interrupt. for 14 d. or longer for reasons other than ADR's, resume tmt. at 90 mg ×1/d for 7 d. before incr. to the prev. tolerated dose.
Tmt. of pts. with anaplastic lymphoma kinase (ALK)-positive metastat. non-small cell lung cancer (NSCLC) who have progres. on or are intolerant to crizotinib.
C/I: Hypersens.
Gamma-Aminobutyric Acid Analog. Pregabalin 25 mg, 50 mg, 75 mg, 100 mg, 150mg, 200 mg, 225 mg, 300 mg. CAPS: 56 x 25 mg, 50 mg, 75 mg, 100 mg, 150mg, 200 mg, 225 mg, 300 mg. The dose range is 150- 600 mg/d given in either two or three divid. doses.
Neuropath. pain: Init. 150 mg per day given as two/ three divid. doses. Based on individ. pt. response and tolerab., the dose may be incr. to 300 mg/ d after an interv.of 3 - 7 days, and if needed, to a max. dose of 600 mg/ d after an addit. 7-day interval.
Fibromyalgia: The usual dose 300 -450 mg/d given in two divid. doses. Some pts. may derive addit. benefit at 600 mg/ d. Dosing should begin at 75mg ×2/d (150 mg/d) and may be incr. to 150 mg ×2/d t (300 mg/d) within 1 wk. based on effic. and tolerab. Pts. who do not experience suffic. benefit with 300 mg/d may be further incr. to 225 mg ×2/d (450 mg/d). If needed, in some pts., based on individ. response and tolerab., the dose may be incr. to max. dosage of 600 mg/d after an addit. wk.
Discont. of pregabalin: It is recommended that the discont. of the drug will be done gradual. over a minim. 1 wk. independent of the indicat.
Renal impair.: For pts. receiving haemodialysis, the pregabalin dly. dose should be adjust. based on ren. funct. In addit. to the dly. dose, a supplem. dose should be given immediate. follow. every 4-h haemodialysis tmt.
Hep. impair.: No dosage adjust. is needed. See lit.
For the treatment of peripheral and central neuropathic pain in adults. Management of Fibromyalgia.
C/I: Hypersens.
Enzyme Preparation. Amylase 3,600, 8000, 18,000 Ph.Eur. units, Lipase 5,000, 10,000, 25,000 Ph.Eur. units, Protease 200, 600, 1,000 Ph.Eur. units. 10000: CAPS: 100. Initial: 1-2 caps with meals. Incr. dose if necess. slowly with
monitor.
25000: CAPS: 100. Initial: 1 cap with meals.
Incr. if reqd. with careful monitoring and
symptomatology.
MICRO: BOTTLE (Gastro-resist.granul.):20gr
Initial. 100 mg (5000 lipase un.) of
gastro-resist. granules (one measure)
should be taken with each feed or
meal. Dose incr., if required, should be
added slowly, with careful monitor. of
response and symptomatology. Max.
dly. dosage should not exceed 10,000
un. lipase/kg/d. See lit.
Pancreat. exocrine insuffic.
C/I: Hypersens. to pancreatin of porcine
origin or to excips.
Phosphodiesterase-5 Enzyme Inhibitor. Sildenafil 25, 50, 100 mg. F.C. TABS: 4, 8 x 25 mg, 50 mg, 100 mg.
50 mg 1 hr. bef. sex. intercourse. May
incr. to 100 mg or decr. to 25 mg. Max:
100 mg/day. Over 65 yrs: Initial: 25 mg.
Erectile dysfunct.
Nicotine Receptor Partial Agonist. Varenicline (as tartrate) 0.5 mg, 1 mg. TABS: 55 x 0.5 mg, 56 x 1 mg; starter
pack: 11 x 0.5 mg + 14, 28 x 1 mg.
One wk. bef. preset date to start: Days
1-3: 0.5 mg 1 x dly. Days 4-7: 0.5 mg 2 x
dly. Days 8-end of tmt: 1 mg 2 x dly.
Taken aft. meal, swallow with full glass
of water. Tmt. should last 3-6 mths. See
lit.
Aid to smoking cessat. adults over 18
yrs.
C/I: Not to pts. under 18 yrs, hypersens.
Analgesic, Antipyretic. Paracetamol 500 mg. TABS: 20 x 500 mg. 1-2 tabs. every 4-6
hrs. Not to exceed 8 tabs/day. Child:
6-12 yrs: 1/2 adult dose. Not to exceed
4 doses in 24 hrs.
CAPLETS: 14, 21. (blister pack), 50 x 500
mg.
1-2 caplets every 4-6 hrs. Not to
exceed 8 caplets/day.
Pain, fever.
Progestogen. Dydrogesterone 10 mg. TABS: 20,42. In comb. with cont. estrogen
ther: 1 tab dly for 14 consec. days/28
day cycle. In comb. with cyclical
estrogen ther: 1 tab dly dur. last 12-14
days estrogen ther. If inad.
progestational response: 20 mg to be
given.
Progeston supplement.
C/I: Hypersens.
Vitamin B12 1 mg/ml. AMPS: 100 x 1 ml. Initial: 250-1000 μg
alt. days for 1-2 wks. foll. by 250 μg
wkly. Maint: 1000 μg mthly, S.C. or I. M.
Pernic. anem, vit. B12 defic., macrocyt.
anem.
Antihistamine. Dimethindene Maleate 1 mg/ml. ORAL DROPS: 20 ml x 1 mg/ml (0.05
mg/drop). 20-40 drops 3 x dly. Child:
about 0.1 mg/kg bdy wt. 1 mth-1 yr:
3-10 drops 3 x dly, 1-3 yrs: 10-15 drops
3 x dly; 3-12 yrs: 15-20 drops 3x dly.
Prurit., allerg. conds.
Advanced Therapy. Darvadstrocel 30 million cells/vial. VIAL(suspens. for inj): 1×30 million cells. A single dose of Alofisel consists of 120 million cells distribut. in 4 vial. Each vial contains 30 million cells in 6 mL of susp. The full content of the 4 vial. must be admin.for the tmt. of up to two intern. openings and up to three exter. openings. This means that with a dose of 120 million cells it is possible to treat up to three fistula tracts that open to the perianal area. There is currently limited exper. with the efficacy or safety of repeat admin. of this drug.
Tmt. of complex perianal fistulas in adult pts. with non-active/mildly active luminal Crohn’s dis., when fistulas have shown an inadeq. response to at least one convention. or biologic ther. The durg should be used after conditioning of fistula.
C/I: Hypersens. to the active subst. or to excipients.
