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שילוב של פקטורים גנטיים המשפיעים על התהליכים הפקרמקוקינטיקיים והפרמקודינמיים של התרופה טקרולימוס במטופלים סינים הסובלים ממיאסטניה גרביס
CCB, Local Anesthetic. Lidocaine HCl 1.5%, Nifedipine 0.3%. RECTAL CR.: 30g. Should be applied twice dly. for at least 3 wks. See lit.
Tmt. of anal fissures and proctolog. general. associate. with anal sphincter hypertonia.
C/I: Hypersens. to the active ingred., partic. to Lidocaine (& other local anesthet. with a similar amidic type structure). Presumed or ascertained preg. & lact.
Gilteritinib (as fumarate) 40 mg. F.C. TABS.: 84. Gilteritinib may be re init. in pts. follow. haematopoietic stem cell transplantation (HSCT). The recomm. start. dose is 120 mg gilteritinib (three 40 mg tabs.) once dly. Tmt. should cont.until the pt. is no longer clinical. benefiting from Gilteritinib or until unacceptab. toxicity occurs. Response may be delayed; therefore, cont. of tmt. at the prescribed dose for up to 6 months should be consid. to allow time for a clinical response. In the absence of a response (pt. did not achieve a CRc) after 4 wks. of tmt., the dose can be incr.to 200 mg (five 40 mg tabs.) once dly., if tolerated or clinically warranted. See lit. Indicated as monother. for the tmt. of adult pts. who have relapsed or refractory acute myeloid leukaemia (AML) with a FLT3 mutation.
Urinary Tract Analgesic. Phenazopyridine (as HCl) 100 mg. TABS: 30. Adult and children over 12
years: 2 drugs. 3 x dly. Aft. meals.
Children from 6 to 12 years: 12mg/kg
bdy wt divided into 3 daily doses.
Relief pain, burning, urgency.
C/I: G6PD deficiency, renal insuffic.
hepatic insuffic., hepatitis, hypersens.
Analgesic, Antipyretic, Opioid. Caffeine 50 mg, Codeine Phosphate 15 mg, Paracetamol 500 mg. CAPLETS: 12, 24. 1 capl. × 3-4 times/day. For severe pains - 2 capl. 3-4 times/day. Do not exceed a dosage of 8 capl. in 24 hrs. See lit.
For the relief of pain and coughs and for the reduction of fever accompanied by pain.
C/I: Hypersens. 1st & 3rd trim. of preg. Lact. Child. under 12 yrs. old. Adolesc. over 12 yrs. old and under 18 yrs. old after surg. remov. of their tonsils or adenoids. Concom. use with medic. contain. paracetamol /codeine. Pts. with respirat. depress. Pts. who are known as ultra-rapid metabolizer.
Second Generation (Atypical) Antipsychotic. Cariprazine as HCl salt 1.5, 3, 4.5, 6 mg. CAPS.:30. The recom. start. dose of cariprazine is 1.5 mg ×1/d. Thereafter the dose can be incr. slowly in 1.5 mg increm. to a max. dose of 6 mg/d, if needed. The lowest effective dose should be maint. accord. to the clinical judgement.
Pts. with ren. impair.: No dose adjust. is required in pts. with mild to moder. renal impair. (CrCl) ≥ 30 mL/min and < 89 mL/min). Not recom. in pts. with severe renal impair.( (CrCl)<30 mL/min).
Pts. with hep. impair.: No dose adjust. is required in pts. with mild-moder. hep. impair. (Child-Pugh score between 5-9). Not recom. in pts. with severe hep. impair. (Child-Pugh score 10-15).
Elderly: pts. aged ≥65 yrs.: Dose selection should be more cautious.
Ped. pts.: No data is available.
Tmt . of schizophrenia in adult pts.
Concom. admin. of strong or moderate CYP3A4 inhib. and inducers. See Lit.
Doxorubicin 2mg/ml. VIAL. (Liposome Concentrate for Sol. for IV infus.: 10, 25ml
Dosage must be ajust. individ. according to the pt. indication and tolerability.
1st or 2nd line ther. of AIDS related Kaposis sarcoma in pts. with low CD 4 counts and extensive mucocutaneous or visceral dis.
Tmt. of pts. with metastat. carcinoma of the ovary who are refract.to both paclitaxel and platinium-based chemother. regimens and who may also be refract. to topotecan. Refract. is defined as a pt. having progress. dis.while on tmt. or within 6 mnths. of complet. tmt.
As monother.for pts. with metastat. breast cancer where there is an incr.card. risk.
In comb. with bortezomib for the tmt. of progress. multiplemyeloma in pts. who have received at least one prior ther. and who have already undergone or are unsuit. for bone marrow transplant.
Hypersens. peanut or soya.
Pts. with AIDS-KS that may be effectively treated with local therapy or systemic alfa-interferon.
Anticonvulsant. Lacosamide 50, 100, 150, 200 mg. F.C.TABS.: 14× 50mg
Dosage adjust. Individ accord. age and wt. of the pt.
Adolesc. child. & adult. wt. ≥50 kg: As monother.-The usual initiat. dose is 50,100 mg ×2/d, the dose may be incr. every wk. by 50 mg (admin. twice dly.) until you reach a mainten. dose between 100 mg and 300 mg×2/d.
In comb. with other antiepileptics:
The usual initiat. dose -50 mg ×2/d.
The dose may be incr. every wk. by 50 mg(admin. twice dly.) until you reach a mainten. dose between 100 mg and 200 mg ×2/d.
Pts. ≥50 kg: Lacosamide tmt. with a single load.dose of 200 mg. Starting ongoing mainten. dose 12 hrs. later.
Child. & adolesc.<50 kg: depends on bdy.wt. See lit.
Indicated as monother. and adjunct. ther. in the tmt. of partialonset seizures with/ without secondary generalization in pts. with epilepsy aged 4 yrs. and older.
Pts. with 2nd or 3rd AV block.
Antivirals/HIV. Efavirenz 600 mg, Emtricitabine 200 mg, Tenofovir Disoproxil 245 mg. TABS.:30. Adult.: 1tab×1/d.
The tab. should be swallow. whole, on empty stomach not crushed, chewed or halved. See lit.
Indicated for use alone as a complete regimen or in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults.
Pts. with severe liver disease.
Pts.with cardiac disorders e.g.: QT prolongation, Torsades de Pointes.
Corticosteroid/Beta 2-Agonist. Beclometasone Dipropionate 200mcg/metered dose, Formoterol Fumarate 6mcg/metered dose. INHALER. (Pressurised sol. for inhal).:1×120 actuation.
Adults 18 yrs. and above:
Two inhalations twice dly.
The max. dly. dose is 4 inhalat.
Foster 200/6 should be used as mainten. therapy only. A lower strength (Foster 100/6) is available for mainten. and reliever ther.
Indicated in the regular tmt. of asthma in adult. where use of a comb. product (inhaled corticosteroid and long-act. Β2-ag.) is appropriate:
Pts. not adequate. control. with inhaled corticosteroids and 'as needed' inhaled rapid-acting Β2-agonist.
Pts. already adequat. controlled on both inhaled corticosteroids and long-act. Β2-ag. C/I: Hypersens.