All the Drug Class Drugs
Atypical Antipsychotic. Aripiprazole (as monohydrate) 300 mg, 400 mg. PRE-FILLED SYR. (pwdr.+ solvent for prolong. -release susp.): 1,3. Recom. init. & mainten. dose: 400 mg. once mnthly. as a single inj. (no sooner than 26 d after the previous inj.). After the 1st inj., tmt. with 10 mg-20 mg oral aripiprazole should be cont. for 14 consec. days to maintain therapeutic aripiprazole concent. during init. of ther. See lit.
Maintenan. tmt. of schizophrenia in adult pts. stabilised with oral aripiprazole.
Atypical Antipsychotic. Aripiprazole 5, 10, 15, 30 mg. TABS: 28 x 5 mg, 10 mg, 15 mg, 30
Take whole w/out meals. Schizophren:
Adult >18 yrs: 10-15 mg dly. Maint. 15
mg dly, max. 30 mg dly. Adolescents
(15 yrs and older): recommend. dose
10 mg dly. Max. dly dose: 30 mg.
Mania: Adult >18 yrs: 15 mg daily, incr.
if necess. to 30 mg dly. Not to exceed
recomm. dose. Irritability
Assoc. with Autistic Dis. (6-17 yrs):
initiate at 2.5 mg/d, dose range 5 – 15
mg dly. See lit.
Tmt. of schizophrenia, tmt. of mod.- severe
manic epis. in Bipolar I disord., prevent. of
a new manic epis. in pts who experienced
predomin. manic epis. whose manic
epis. respond. to aripiprazole tmt. Use as
an adjunct. ther. to antidepress. for tmt. of
major depress. dis. (MDD). Efficacy was
establ. in two 6-week trials in adults with
MDD who had an inadeq. resp. to
antidepr. ther. during the curr. epis. Tmt. of
irritability assoc. with autistic dis. Efficacy
was establ. in two 8-week trials in ped. pts
(aged 6 - 17 yrs) with irritab. assoc. with
autistic dis. (incl. sympt. of aggress.
towards others, delib. self-inj., temper
tantrums, quickly chang. moods).
Atypical Antipsychotic. Ziprasidone 20, 40, 60, 80 mg. CAPS: 30, 60 x 20 mg, 40 mg, 60 mg, 80 mg.
VIAL (pwdr. & solvent for sol. for IM inj.): 1×40.93mg.
Caps.: an init. dly. dose of 40 mg×2/d with food. In some pts., dly. dosage may subseq. be adjust. on the basis of individ. clinic. status up to 80 mg×2/d. Dosage adjust., if indicated, should general. occur at interv. of not less than 2 d, as steady-state is achieved within 1-3 d. In order to ensure use of the lowest effective dose, pts. should ordinar. be observed for improv. for several wks. before upward dosage adjust.
Mainten. tmt.: No addit. benefit was demonstr. for doses above 20 mg×2/d.
Bipolar I Disord. (Acute Mixed/ Manic Episodes & Mainten. Tmt. as an Adjunct to Lithium/Valproate)
Acute Tmt. of Manic/Mixed Episodes: Dose Selection-Oral ziprasidone should be admin. at an init. dly. dose of 40 mg×2/d with food. The dose may then be incr. to 60 mg / 80 mg×2/d on the 2nd day of tmt. and subseq. adjust. on the basis of tolerance & effic. within the range 40 mg-80 mg ×2/d.
Mainten. Tmt. (as an adjunct to lithium/valproate): Cont. tmt. at the same dose on which the pt. was init. stabilized, within the range of 40 mg-80 mg×2/d with food.
Acute Tmt. of Agitat. in Schizophrenia
IM Dosing: 10 mg -20 mg admin. as required up to a max. dose of 40 mg/d. Doses of 10 mg may be admin. every two hrs.; doses of 20 mg may be admin. every 4 hrs. up to a max. of 40 mg/d. IM admin. of ziprasidone for more than three consec. days has not been studied.
If long-term ther. is indicated, oral capsules should replace the IM admin. as soon as possible. See lit.
GEODON IM: rapid control of agitation in pts. with schizophrenia, when oral ther. is not appropriate, for a max. of 3 consecut. days.
GEODON CAPS.: Tmt. of schizophrenia and for mainten. of clinic. improv. during contin. ther.
Bipolar mania. as monother. in the tmt. of manic/mixed episodes assoc. with bipolar disord. with/without psychot. features.
Bipolar Disord. -Maintenance tmt. of bipolar disord., as an adjunct to lithium or valproate.
C/I: Pts. with a known hist. of QT prolong. (include. congen. long QT syndr.). Pts. with recent acute MI. Pts. with uncompens. HF. Concom. use with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. See lit.
Atypical Antipsychotic. Clozapine 25 mg, 100 mg. TABS: 50 x 25 mg, 100 mg. Initial: 1-2, 25
mg tabs. on 1st. day. Incr. by 25-50 mg
dly. to max. 600 mg dly. within
7-14 days. May incr. to 900 mg dly in certain cases. See lit.
Tmt. - resist. schizophren. in pts.
unrespons. to or intol. of conventional
neuroleptics. Psychiatrist at mental hosp.