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  • Ziprasidone
    1 Drug classified under this active ingredient

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    Atypical Antipsychotic. Ziprasidone 20, 40, 60, 80 mg.
    CAPS: 30, 60 x 20 mg, 40 mg, 60 mg, 80 mg.
    VIAL (pwdr. & solvent for sol. for IM inj.): 1×40.93mg.
    Caps.: an init. dly. dose of 40 mg×2/d with food. In some pts., dly. dosage may subseq. be adjust. on the basis of individ. clinic. status up to 80 mg×2/d. Dosage adjust., if indicated, should general. occur at interv. of not less than 2 d, as steady-state is achieved within 1-3 d. In order to ensure use of the lowest effective dose, pts. should ordinar. be observed for improv. for several wks. before upward dosage adjust.
    Mainten. tmt.: No addit. benefit was demonstr. for doses above 20 mg×2/d.
    Bipolar I Disord. (Acute Mixed/ Manic Episodes & Mainten. Tmt. as an Adjunct to Lithium/Valproate)
    Acute Tmt. of Manic/Mixed Episodes: Dose Selection-Oral ziprasidone should be admin. at an init. dly. dose of 40 mg×2/d with food. The dose may then be incr. to 60 mg / 80 mg×2/d on the 2nd day of tmt. and subseq. adjust. on the basis of tolerance & effic. within the range 40 mg-80 mg ×2/d.
    Mainten. Tmt. (as an adjunct to lithium/valproate): Cont. tmt. at the same dose on which the pt. was init. stabilized, within the range of 40 mg-80 mg×2/d with food.
    Acute Tmt. of Agitat. in Schizophrenia
    IM Dosing: 10 mg -20 mg admin. as required up to a max. dose of 40 mg/d. Doses of 10 mg may be admin. every two hrs.; doses of 20 mg may be admin. every 4 hrs. up to a max. of 40 mg/d. IM admin. of ziprasidone for more than three consec. days has not been studied.
    If long-term ther. is indicated, oral capsules should replace the IM admin. as soon as possible. See lit.
    GEODON IM: rapid control of agitation in pts. with schizophrenia, when oral ther. is not appropriate, for a max. of 3 consecut. days.
    GEODON CAPS.: Tmt. of schizophrenia and for mainten. of clinic. improv. during contin. ther.
    Bipolar mania. as monother. in the tmt. of manic/mixed episodes assoc. with bipolar disord. with/without psychot. features.
    Bipolar Disord. -Maintenance tmt. of bipolar disord., as an adjunct to lithium or valproate.
    C/I: Pts. with a known hist. of QT prolong. (include. congen. long QT syndr.). Pts. with recent acute MI. Pts. with uncompens. HF. Concom. use with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. See lit.