All the Therapeutic System Drugs
ACE Inhibitor. Captopril 12.5, 25, 50 mg. TABS: 90 x 12.5mg, 25mg, 50mg.
Max. dly. dose: 150 mg. Hypertens: Initial: 25-50 mg 2 x dly in div. doses. Incr.
intervals at least 2 wks: 100-150 mg dly in div. doses to reach target BP.
Heart fail.: Init.: 12.5 mg BID or TID.
Titrat. to maint. dose (75-150 mg dly) at intervals of at least 2 wks. depen. on pt. response.
Type 1 diabet. nephropathy: 75-100 mg dly in div doses.
MI, ren. impair., elderly: See lit.
Hypertens., C.H.F., insulin depend. diabet. nephropathy in hypertens./nonhypertens. pts. when serum creatinine level < 2.5 mg/dl. Improve survival follow. MI in clinic. stable pts. with left ventric. dysfunct. manifest. as eject. fract. < or equals 40% and to reduce incidence of overt heart fail. and subseq. hospitalizat. for C.H.F. in these pts.
C/I: Hypersens. Hypersens. to other ACE inhib.
Hist. of angioedema assoc. with previous ACE-inhib. ther., hered. idiopath. angioedema. 2nd, 3rd trim. of preg.
Concom. use with aliskiren contain. product in pts. with diab. mell. or renal impair. (GFR <60ml/min/1.73 m2). See lit.
Calcium Channel Blocker, Class IV Antiarrhythmic. Diltiazem (as HCl) 120, 180, 240 mg. C.R. CAPS: 30 x 120 mg, 180 mg, 240 mg.
Usual start. dose: 240 mg 1 x dly. All
strengths 1 x dly. See lit.
Chron. stable ang. pect., ang. due to
coronary art. spasm, hypertens.
C/I: Sick-sinus syndr., 2nd or 3rd degree
AV block (unless funct. ventric.
pacemaker present), severe bradycard.,
severe heart fail., severe hypotens. (syst.
press. < 90 mm Hg), acute M.I.,
radiograph. pulm. congest.
Aldosterone Antagonist. Spironolactone 25 mg. TABS: 20 x 25 mg. 50-100 mg dly.
Congest. card. fail. with oedema
For manag. of edema an init. dly. dose
of 100 mg of spironolactone admin. in
either single or divided doses is
recom., but may range from 25 mg-
200 mg dly. Mainten. dose should be
Pts. who tolerate 25 mg once dly. may
have their dose incr. to 50 mg×1/d. as
clinic. indic. Pts. who do not tolerate
25mg ×1/d may have their dose
reduced to 25 mg every other d.
Admin. with food.
Congest. heart fail; Cirrhot. ascites.
C/I: Acute renal insuffic. , signific. renal
compromise, anuria; Addison’s dis.;
Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
eplerenone or other K+ spar. diuret.;
Ped. pts. with moder.- sev. renal impair.;
Concom. use with other K+conserve.
diuret., K+supplem. should not be given
routin. with Aldactone as hyperkalaem.
may be induced.
Calcium Channel Blocker. Amlodipine Besylate 5 mg, 10 mg. TAB: 20, 30. Hypertens. and angina: Initial.
5 mg dly, may incr. to max dly dose of
10 mg depend. on pt. response.
Dose titrat. can proceed over 7-14 days
but may proceed more rapidly if clinic.
warranted. No dose adjust. reqd. when
used tog. with thiazide diuret.,
ß-blockers and ACE inhibits. Elderly: As
in younger pts. Child: Safety and effect.
have not been established.
Mild to mod. hypertens., chron. stable
ang., confirmed or susp. vasospastic ang.
(Prinzmetal’s or variant ang.). May be
used alone or in combin. with other
antihypertens. or antiang. agents.