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  • Anti-Hypertensives
    59 Drugs classified under this therapeutic system

    All the Therapeutic System Drugs

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    ACE Inhibitor. Captopril 12.5, 25, 50 mg.
    TABS: 90 x 12.5mg, 25mg, 50mg.
    Max. dly. dose: 150 mg. Hypertens: Initial: 25-50 mg 2 x dly in div. doses. Incr.
    intervals at least 2 wks: 100-150 mg dly in div. doses to reach target BP.
    Heart fail.: Init.: 12.5 mg BID or TID.
    Titrat. to maint. dose (75-150 mg dly) at intervals of at least 2 wks. depen. on pt. response.
    Type 1 diabet. nephropathy: 75-100 mg dly in div doses.
    MI, ren. impair., elderly: See lit.
    Hypertens., C.H.F., insulin depend. diabet. nephropathy in hypertens./nonhypertens. pts. when serum creatinine level < 2.5 mg/dl. Improve survival follow. MI in clinic. stable pts. with left ventric. dysfunct. manifest. as eject. fract. < or equals 40% and to reduce incidence of overt heart fail. and subseq. hospitalizat. for C.H.F. in these pts.
    C/I: Hypersens. Hypersens. to other ACE inhib.
    Hist. of angioedema assoc. with previous ACE-inhib. ther., hered. idiopath. angioedema.   2nd, 3rd trim. of preg.
    Concom. use with aliskiren contain. product in pts. with diab. mell. or renal impair. (GFR <60ml/min/1.73 m2). See lit.

    Adizem CD
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    Adizem CD

    Calcium Channel Blocker, Class IV Antiarrhythmic. Diltiazem (as HCl) 120, 180, 240 mg.
    C.R. CAPS: 30 x 120 mg, 180 mg, 240 mg.
    Usual start. dose: 240 mg 1 x dly. All
    strengths 1 x dly. See lit.
    Chron. stable ang. pect., ang. due to
    coronary art. spasm, hypertens.
    C/I: Sick-sinus syndr., 2nd or 3rd degree
    AV block (unless funct. ventric.
    pacemaker present), severe bradycard.,
    severe heart fail., severe hypotens. (syst.
    press. < 90 mm Hg), acute M.I.,
    radiograph. pulm. congest.

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    Aldosterone Antagonist. Spironolactone 25 mg.
    TABS: 20 x 25 mg. 50-100 mg dly.
    Congest. card. fail. with oedema
    For manag. of edema an init. dly. dose
    of 100 mg of spironolactone admin. in
    either single or divided doses is
    recom., but may range from 25 mg-
    200 mg dly. Mainten. dose should be
    individ. determin.
    Pts. who tolerate 25 mg once dly. may
    have their dose incr. to 50 mg×1/d. as
    clinic. indic. Pts. who do not tolerate
    25mg ×1/d may have their dose
    reduced to 25 mg every other d.
    Admin. with food.
    Congest. heart fail; Cirrhot. ascites.
    C/I: Acute renal insuffic. , signific. renal
    compromise, anuria; Addison’s dis.;
    Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
    eplerenone or other K+ spar. diuret.;
    Ped. pts. with moder.- sev. renal impair.;
    Concom. use with other K+conserve.
    diuret., K+supplem. should not be given
    routin. with Aldactone as hyperkalaem.
    may be induced.

    Amlodipine Teva
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    Amlodipine Teva

    Calcium Channel Blocker. Amlodipine Besylate 5 mg, 10 mg.
    TAB: 20, 30. Hypertens. and angina: Initial.
    5 mg dly, may incr. to max dly dose of
    10 mg depend. on pt. response.
    Dose titrat. can proceed over 7-14 days
    but may proceed more rapidly if clinic.
    warranted. No dose adjust. reqd. when
    used tog. with thiazide diuret.,
    ß-blockers and ACE inhibits. Elderly: As
    in younger pts. Child: Safety and effect.
    have not been established.
    Mild to mod. hypertens., chron. stable
    ang., confirmed or susp. vasospastic ang.
    (Prinzmetal’s or variant ang.). May be
    used alone or in combin. with other
    antihypertens. or antiang. agents.

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    Calcium Channel Blocker. Amlodipine Maleate 5 mg, 10 mg.
    TABS: 20. Initial: 5 mg 1 x dly. May incr.
    to max. 10 mg dly depend. on pt.
    response. Elderly and young pts:
    Normal dosage regimen.
    Mild to mod. hypertens., vasospastic
    angina (Prinzmetal’s or variant angina),
    chronic stable angina.

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    Angiotensin II Antagonist. Candesartan Cilexetil 4 mg, 8 mg, 16 mg.
    TABS: 28 x 8 mg, 16 mg. Initial: 8 or 16
    mg 1 x dly. Maint: 8 or 16 mg 1 x dly,
    with or without food. Max. effect: 4
    C/I: Hypersens., pregn., lact.

    Other therapeutic systems under Cardiovascular System