All the Drug Class Drugs
Angiotensin II Antagonist. Candesartan Cilexetil 4 mg, 8 mg, 16 mg. TABS: 28 x 8 mg, 16 mg. Initial: 8 or 16
mg 1 x dly. Maint: 8 or 16 mg 1 x dly,
with or without food. Max. effect: 4
wks.
Hypertens.
C/I: Hypersens., pregn., lact.
Angiotensin II Antagonist, Diuretics. Candesartan Cilexetil 16 mg, Hydrochlorothiazide 12.5 mg. TABS: 28. 1 tab x dly with or without
food. Elderly: No special dosage. Use
in pts with impair. ren. fusal: see lit.
Not recommend. for child.
Antihypertens. effect usually attained
within 4 wks.
Essent. hypertens. where monother. with
candesartan cilexetil or HCTZ is not
suffic.
C/I: Hypersens., severe ren. impair.,
severe hepat. impair and / or cholestas.,
gout.
Angiotensin II Antagonist. Candesartan Cilexetil 8 mg, 16 mg. TABS: 8 mg, 16 mg. For dosage see lit.
Hypertens. Tmt. of pts. with heart fail. and impair. lf. ventr. syst. func.(LVEF<=40%) as add-on ther. to ACE-inh. or when ACE-inh. Are not toler.
C/I: See lit.
Angiotensin II Antagonist, Diuretics. Candesartan Cilexetil 16 mg, Hydrochlorothiazide 12.5 mg. TABS: 28. 1 tab dly. See lit.
Essent. HTN, where monother. with
candesartan cilexetil or HCTZ is not
sufficient.
C/I: Hypersens. to ingredients/
sulfonamide derived drugs, pregn., lact.,
severe ren. impair., severe hepat. impair./
cholestas., hypokalem., hypocalcem.,
gout, tmt. with aliskiren in diabetic pts.
or pts. with impair. renal func.
Angiotensin II Antagonist, Thiazide. Valsartan 80 mg, 160 mg, Hydrochlorothiazide 12.5 mg, 25 mg. CO-DIOVAN 80: F.C. TABS: 28. 1 tab dly. Max. effect within 2-4 wks.
Hypertens. when comb. ther. appropriate.
CO-DIOVAN 160: F.C. TABS: 28. 1 tab dly.
Hypertens., when blood pressure not adequat. controlled by monother. To be used as second-line ther.
C/I: Hypersens. Hypersens. to sulfonamide-derived med. products. 2nd & 3rd trim. of preg. Biliary cirrhos. and cholestasis. Pts. with anuria. Refractor. hypokalaemia, hyponatraemia, hypercalcaemia, and symptomat. hyperuricaemia. Concom. use with aliskiren-contain. products in pts. with diab. mell. or renal impair. (GFR <60 mL/min/1.73m²).
Angiotensin II Antagonist. Valsartan 40, 80 ,160 mg. F.C. TABS.: 28. Hyperten.: 80 mg×1/d most
pts. The antihypertens. effect is
substantial. present within 2 wks. and
max. effects are seen after 4 wks.
In some pts. whose blood press. is not
adequate. control., the dose may be
incr. to 160 mg, or a greater decr. in BP
may be achieved by add. in a thiazide
diuret. See lit.
Heart fail.: 40 mg ×1/d.
Uptitration to 80 mg, 160 mg×2/d
should be done to the highest dose
tolerat. by the pt.
Considerat. should be given to
reducing the dose of concom. diuret.
The max. dly. dose admin. in clin. trials
is 320 mg in divided doses. See lit.
Post-MI.: Achievem. of the target dose
of 160 mg×2/d should be based on the
pt’s tolerab. to valsartan during titrat. If
symptomat. hypotension or renal
dysfunct. occurs, consider. should be
given to a dosage reduct. See lit.
Therapy may be init. as early as 12 hrs.
after a MI . After an initial dose of 20 mg ×2/ d, valsartan ther. should be
titrated to 40 mg, 80 mg, and 160 mg
×2/ d over the next few wks. The start.
dose is provided by the 40 mg divisible
tab.
Tmt. of hypertens.: 80 mg and 160 mg.
Heart fail.: 40 mg, 80 mg and 160 mg.
Tmt. of heart fail. (NYHA class II‐IV) in pts.
who are intoler. of angiotens. Convert.
enzyme inhib. See lit.
Post-myocard. infarction (40 mg, 80 mg
and 160 mg): Indicat. to improve survival follow. myocard. infarct. in clinical. stable pts. with signs, sympt. or radiolog. evidence
of left ventric. fail. and/or with left
ventric. systolic dysfunct. See lit.
C/I: Known hypersens. to valsartan or to
any of the excip. Preg., and lact.
Sev. hepatic impair., cirrhosis, biliary
obstruct. Concom. use of angiotensin
recept. antagonists (ARBs) ‐ includ.
valsartan ‐ or of ACEIs with aliskiren is
contraind. in pts. with diab. mell. or renal
impair.(GFR < 60 ml/min/1.73 m²). See
lit.
