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  • Spironolactone
    2 Drugs classified under this active ingredient


    All the Active Ingredient Drugs

    Aldactone
    Pfizer
    RX
    full basket chart
    Aldactone

    Aldosterone Antagonist. Spironolactone 25 mg.
    TABS: 20 x 25 mg. 50-100 mg dly.
    Congest. card. fail. with oedema
    For manag. of edema an init. dly. dose
    of 100 mg of spironolactone admin. in
    either single or divided doses is
    recom., but may range from 25 mg-
    200 mg dly. Mainten. dose should be
    individ. determin.
    Pts. who tolerate 25 mg once dly. may
    have their dose incr. to 50 mg×1/d. as
    clinic. indic. Pts. who do not tolerate
    25mg ×1/d may have their dose
    reduced to 25 mg every other d.
    Admin. with food.
    Congest. heart fail; Cirrhot. ascites.
    C/I: Acute renal insuffic. , signific. renal
    compromise, anuria; Addison’s dis.;
    Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
    eplerenone or other K+ spar. diuret.;
    Ped. pts. with moder.- sev. renal impair.;
    Concom. use with other K+conserve.
    diuret., K+supplem. should not be given
    routin. with Aldactone as hyperkalaem.
    may be induced.

    Spironolactone Teva
    Teva
    RX
    full basket chart
    Spironolactone Teva

    Aldosterone Antagonist. Spironolactone 25 mg, 100 mg.
    TABS: 20 x 25 mg, 20 x 100 mg.
    Admin.  once dly. with a meal is recomm.
    Adult.: CHF with oedema: For manag. of oedema an init. dly. dose of 100 mg admin. in either single or divid. doses is recomm., but may range from 25 mg -200 mg dly. Mainten. dose should be individ. determin.
    Severe heart fail.(NYHA Class III-IV): Based on the Randomized Aldactone Evaluat. Study, tmt. in conjunct. with standard therapy should be init. at a dose
    of spironolactone 25 mg ×1/d if serum K+ is ≤5.0 mEq/L and serum Cr is ≤2.5 mg/dL. Pts. who tolerate 25 mg×1/d may have their dose incr. to 50 mg ×1/d as clinic. indic.. Pts. who do not tolerate 25 mg×1/d may have their dose reduced to 25 mg every other day. See lit.
    Hepatic cirrhosis with ascites and oedema: If urinary Na+/K+ ratio is greater than 1.0, 100 mg/day. If the ratio is less than 1.0, 200 mg/day to 400 mg/d. Mainten. dosage should be individ. determ.
    Elder.: It is recomm. that tmt. is started with the lowest dose and titrated upwards as requir. to achieve max. benefit. Care should be taken with severe hep. and renal impair. which may alter drug metabolism and excretion.
    Ped. population: Init. dly. dosage should provide 3 mg/kg bdy. wt. given in divided doses. Dosage should be adjust. on the basis of response and tolerance.
    Child. should only be treated under guidance of a paediatric specialist. There is limited ped. data available.
    Ed. conds. in pts. with congest. heart fail., hepatic cirrhosis with ed.,
    essential 
    hypertens., hypokalem, diagn. of prim. hyperaldosteronism.
    C/I: Hypersens.
    Adult. and ped. pts.  patients with acute renal insuffic., signific. renal compromise, anuria, addison’s dis., hyperkalaem.
    Concom. use of eplerenone or other K+ spar. diuret.
    Spironolactone should not be admin.concurr. with other K+  conserve. diuret. and K+  supplem. should not be given routinely with Spironolactone as hyperkalaem. may be induced.
    Ped. pts. with moder.- sev. ren. impair.

     

     

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