All the Drug Class Drugs
Aldosterone Antagonist. Spironolactone 25 mg. TABS: 20 x 25 mg. 50-100 mg dly.
Congest. card. fail. with oedema
For manag. of edema an init. dly. dose
of 100 mg of spironolactone admin. in
either single or divided doses is
recom., but may range from 25 mg-
200 mg dly. Mainten. dose should be
Pts. who tolerate 25 mg once dly. may
have their dose incr. to 50 mg×1/d. as
clinic. indic. Pts. who do not tolerate
25mg ×1/d may have their dose
reduced to 25 mg every other d.
Admin. with food.
Congest. heart fail; Cirrhot. ascites.
C/I: Acute renal insuffic. , signific. renal
compromise, anuria; Addison’s dis.;
Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
eplerenone or other K+ spar. diuret.;
Ped. pts. with moder.- sev. renal impair.;
Concom. use with other K+conserve.
diuret., K+supplem. should not be given
routin. with Aldactone as hyperkalaem.
may be induced.
Aldosterone Antagonist. Eplerenone 25 mg, 50 mg. TABS. :28. For the individ. adjust. of
dose, of 25 mg, 50 mg are available.
The max. dose 50 mg dly.
For post-MI heart fail. pts.:
The recomm. maint. dose of
eplerenone is 50 mg×1/d. Tmt. should
be initiated at 25 mg×1/d and titrat. to
the target dose of 50 mg×1/d
preferably within 4 wks., taking into
account the serum K+ level.
Eplerenone ther. should usually be
start. within 3-14 d after an acute MI.
For pts. with NYHA class II (chron.)
heart fail.: For chron. heart fail. NYHA
class II pts., tmt. should be init. at a
dose of 25 mg×1/d and titrat. to the
target dose of 50 mg×1/d preferably
within 4 wks.; taking into account the
serum K+ level. See lit.
Eplerenone is indicated In addit. to
standard ther. include. β-block., to reduce
the risk of CV mortal. & morbid. in stable
pts. with left LVEF ≤ 40 % and clin.
evidence of heart fail. after recent MI.
In addit.to standard optimal ther., to
reduce the risk of CV mortal. and morbid.
in adult pts. with NYHA class II (chron.)
heart fail.and left ventric. syst. dysfunct.
C/I: Hypersens. Pts. with clin. signific.
hyperkalem. or with condit. assoc. with
hyperkalem. Pts. with serum K+ level >5.0 mmol/L at init. Pts. with sev. renal
insuffic. (eGFR <30 mL per min. per 1.73
m2). Pts. with sev. hep. insuffic. (Child-
Pugh Class C). Pts. receiv. K+ -spar.
diuretics, K+ -supplem. or strong inhib.
of CYP 3A4 (e.g., itraconazole,
ketoconazole, ritonavir, nelfinavir,
nefazodone). The comb.of an ACE’s
inhib. and an ARB’s inhib with
Aldosterone Antagonist. Spironolactone 25 mg, 100 mg. TABS: 20 x 25 mg, 20 x 100 mg.
Hypertens: 50-100 mg dly. Ed: 25-200
mg dly. in div. doses. Prim.
hyperaldoster: 400 mg dly. in div.
doses for 3-4 wks; Hypokalem: 25-100
Ed. conds. in pts. with congest. heart fail.,
hepatic cirrhosis with ed., essential
hypertens., hypokalem, diagn. of prim.