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  • Aldosterone Antagonist
    3 Drugs classified under this drug class


    All the Drug Class Drugs

    Aldactone
    Pfizer
    RX
    full basket chart
    Aldactone

    Aldosterone Antagonist. Spironolactone 25 mg.
    TABS: 20 x 25 mg. 50-100 mg dly.
    Congest. card. fail. with oedema
    For manag. of edema an init. dly. dose
    of 100 mg of spironolactone admin. in
    either single or divided doses is
    recom., but may range from 25 mg-
    200 mg dly. Mainten. dose should be
    individ. determin.
    Pts. who tolerate 25 mg once dly. may
    have their dose incr. to 50 mg×1/d. as
    clinic. indic. Pts. who do not tolerate
    25mg ×1/d may have their dose
    reduced to 25 mg every other d.
    Admin. with food.
    Congest. heart fail; Cirrhot. ascites.
    C/I: Acute renal insuffic. , signific. renal
    compromise, anuria; Addison’s dis.;
    Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
    eplerenone or other K+ spar. diuret.;
    Ped. pts. with moder.- sev. renal impair.;
    Concom. use with other K+conserve.
    diuret., K+supplem. should not be given
    routin. with Aldactone as hyperkalaem.
    may be induced.

    Inspra
    Pfizer
    RX
    partial basket chart
    Inspra

    Aldosterone Antagonist. Eplerenone 25 mg, 50 mg.
    TABS. :28. For the individ. adjust. of
    dose, of 25 mg, 50 mg are available.
    The max. dose 50 mg dly.
    For post-MI heart fail. pts.:
    The recomm. maint. dose of
    eplerenone is 50 mg×1/d. Tmt. should
    be initiated at 25 mg×1/d and titrat. to
    the target dose of 50 mg×1/d
    preferably within 4 wks., taking into
    account the serum K+ level.
    Eplerenone ther. should usually be
    start. within 3-14 d after an acute MI.
    See lit.
    For pts. with NYHA class II (chron.)
    heart fail.: For chron. heart fail. NYHA
    class II pts., tmt. should be init. at a
    dose of 25 mg×1/d and titrat. to the
    target dose of 50 mg×1/d preferably
    within 4 wks.; taking into account the
    serum K+ level. See lit.
    Eplerenone is indicated In addit. to
    standard ther. include. β-block., to reduce
    the risk of CV mortal. & morbid. in stable
    pts. with left LVEF ≤ 40 % and clin.
    evidence of heart fail. after recent MI.
    In addit.to standard optimal ther., to
    reduce the risk of CV mortal. and morbid.
    in adult pts. with NYHA class II (chron.)
    heart fail.and left ventric. syst. dysfunct.
    (LVEF ≤30%).
    C/I: Hypersens. Pts. with clin. signific.
    hyperkalem. or with condit. assoc. with
    hyperkalem. Pts. with serum K+ level >5.0 mmol/L at init. Pts. with sev. renal
    insuffic. (eGFR <30 mL per min. per 1.73
    m2). Pts. with sev. hep. insuffic. (Child-
    Pugh Class C). Pts. receiv. K+ -spar.
    diuretics, K+ -supplem. or strong inhib.
    of CYP 3A4 (e.g., itraconazole,
    ketoconazole, ritonavir, nelfinavir,
    clarithromycin, telithromycin,
    nefazodone). The comb.of an ACE’s
    inhib. and an ARB’s inhib with
    eplerenone.

    Spironolactone Teva
    Teva
    RX
    full basket chart
    Spironolactone Teva

    Aldosterone Antagonist. Spironolactone 25 mg, 100 mg.
    TABS: 20 x 25 mg, 20 x 100 mg.
    Hypertens: 50-100 mg dly. Ed: 25-200
    mg dly. in div. doses. Prim.
    hyperaldoster: 400 mg dly. in div.
    doses for 3-4 wks; Hypokalem: 25-100
    mg dly.
    Ed. conds. in pts. with congest. heart fail.,
    hepatic cirrhosis with ed., essential
    hypertens., hypokalem, diagn. of prim.
    hyperaldosteronism.

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