All the Therapeutic System Drugs
Aldosterone Antagonist. Spironolactone 25 mg. TABS: 20 x 25 mg. 50-100 mg dly.
Congest. card. fail. with oedema
For manag. of edema an init. dly. dose
of 100 mg of spironolactone admin. in
either single or divided doses is
recom., but may range from 25 mg-
200 mg dly. Mainten. dose should be
Pts. who tolerate 25 mg once dly. may
have their dose incr. to 50 mg×1/d. as
clinic. indic. Pts. who do not tolerate
25mg ×1/d may have their dose
reduced to 25 mg every other d.
Admin. with food.
Congest. heart fail; Cirrhot. ascites.
C/I: Acute renal insuffic. , signific. renal
compromise, anuria; Addison’s dis.;
Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
eplerenone or other K+ spar. diuret.;
Ped. pts. with moder.- sev. renal impair.;
Concom. use with other K+conserve.
diuret., K+supplem. should not be given
routin. with Aldactone as hyperkalaem.
may be induced.
Thiazide Diuretic. Hydrochlorothiazide 25 mg. TABS: 30.
High Blood Pressure: The initial dose is
12.5 - 25 mg HCTZ/day. The long-term
dose is usually 12.5 mg HCTZ/day.
Cardiac/hepatic/renal edema: The initial
dose is 25 mg or 50 mg HCTZ/day. The
long-term dose is usually 25 - 100 mg
Patients with impaired cardiac/liver/
kidney function: Dose should be
adjusted. Elderly (above 65 years old):
Attention should be paid to possible
restrictions to kidney function. See lit.
C/I: Hypersensitivity to HCTZ or to any of
the medicine’s ingredients, other
thiazides, other products which are
based on sulfonamide; severe
disturbances to kidney function (renal
insufficiency with oliguria or anuria);
glomerulonephritis; severe liver
impairment like liver failure with
impaired consciousness (coma and
hepatic precoma); hypokalaemia;
hypercalcaemia; high uric acid levels in
the blood which are causing symptoms
(patients with gout in the history); gout;
breastfeeding. See lit.
Loop Diuretic. Furosemide 40 mg. TABS: 30, 50 x 40 mg. Ed: Initial: 1/2-2 tabs.
incr. by 1/2 or 1 tab. every 6-8 hrs.
depend. on response. See lit.
Hypertens: Init: 40 mg 2 x dly. Adjust.
accord. response. Infant and child: 2
mg/kg bdy wt. incr. by 1-2 mg/kg bdy
wt. depend. on response. See lit.
K+ Sparing Diuretic, Thiazide Diuretic. Amiloride HCl 5 mg, Hydrochlorothiazide 50 mg. TABS: 30. Ed: 1-2 tabs. dly. Hypertens: 1
tab. dly. as single dose or in div. doses.
Not to exceed 2 tabs. dly.
Ed: ed. assoc. with congest. card. fail.
hepat. cirrh. Hypertens: as sole ther.
agent or to enhance effectiveness of
other antihypertens. drugs.
C/I: Anuria, severe progress. renal dis.,
acute renal fail., elevated serum potass.
levels, hypersens. to any of compon.