All the Therapeutic System Drugs
Aldosterone Antagonist. Spironolactone 25 mg. TABS: 20 x 25 mg. 50-100 mg dly.
Congest. card. fail. with oedema
For manag. of edema an init. dly. dose
of 100 mg of spironolactone admin. in
either single or divided doses is
recom., but may range from 25 mg-
200 mg dly. Mainten. dose should be
individ. determin.
Pts. who tolerate 25 mg once dly. may
have their dose incr. to 50 mg×1/d. as
clinic. indic. Pts. who do not tolerate
25mg ×1/d may have their dose
reduced to 25 mg every other d.
Admin. with food.
Congest. heart fail; Cirrhot. ascites.
C/I: Acute renal insuffic. , signific. renal
compromise, anuria; Addison’s dis.;
Hyperkalaem.; Hypersens. to spironolactone.; Concom. use of
eplerenone or other K+ spar. diuret.;
Ped. pts. with moder.- sev. renal impair.;
Concom. use with other K+conserve.
diuret., K+supplem. should not be given
routin. with Aldactone as hyperkalaem.
may be induced.
Thiazide Diuretic. Hydrochlorothiazide 25 mg. Tabs: 30 X 25 mg. High blood press: Init. dose: half a tab. or 1 tab. once dly. (12.5-25 mg HCTZ/day). Long-term dose is usually half tab. once dly. (12.5 mg HCTZ/day).
Cardiac/hepatic/renal edema: init. dose: 25mg or 50 mg once dly.
Long-term dose is usually 25mg to 100mg once dly.
Diuretic for hypertens., edema.
C/I: Hypersens. to the act. subst., to other thiazides, sulfonamides or to any of excip., severe renal impair., anuria, acute glomerulonephritis., sev. liver function impair. (coma and hepatic precoma), ther.-resist. hypokalaemia, hyponatraemia or hypercalcaemia, hypovolemia, symptom. hyperuricaemia/gout, hypertens. during pregn. See lit.
Loop Diuretic. Furosemide 250 mg/25 ml. Vials. Sol. for inf. 50X 250 mg/25 ml:
For adlts., max recomm. dose is 1,500 mg/d, may reach 2,000 mg in except. cases.
For childr., max recomm. dly dose for parenteral admin. is 1 mg of furosemide per kg of BW up to a max of 20 mg.
Potent diuretic when a prompt and effect. diuresis is req.
Appropr. for emerg. or where oral ther. is not feasible. for cardiac, pulm., hepatic and renal oedema
C/I: Hypersens. to amiloride, sulphonamides or sulphonamide derivatives/ Hypovol. and dehydr. (with or without hypotension)/ Severe hypokalemia: severe hyponatremia/ Comatose or pre-comat. states assoc. with hepatic cirrh./ Anuria or renal fail. with anuria not resp. to furosemide, renal fail. as a result of poison. by nephrotox. or hepatotox. agents, renal fail. assoc. with hepat. coma/ Imp. renal funct. with creat. clear. below 30 ml/min per 1.73 m2 body surf. area/ Addison's disease/ Digitalis intox/ Porphyria/ Breast-feed.
Loop Diuretic. Furosemide 40 mg. TABS: 30, 50 x 40 mg. Ed: Initial: 1/2-2 tabs.
incr. by 1/2 or 1 tab. every 6-8 hrs.
depend. on response. See lit.
Hypertens: Init: 40 mg 2 x dly. Adjust.
accord. response. Infant and child: 2
mg/kg bdy wt. incr. by 1-2 mg/kg bdy
wt. depend. on response. See lit.
Edem., hypertens.
Loop Diuretic. Furosemide 20 mg / 2 ml. AMPS: 5, 25 x 20 mg/2 ml. Initial: 20-40
mg as single I.V. or I.M./ dose.
Oligur. due to acute/chron. renal insuffic.
glom. filt. rate below 20 ml/min,
hypertens.
K+ Sparing Diuretic, Thiazide Diuretic. Amiloride HCl 5 mg, Hydrochlorothiazide 50 mg. TABS: 30. Ed: 1-2 tabs. dly. Hypertens: 1
tab. dly. as single dose or in div. doses.
Not to exceed 2 tabs. dly.
Ed: ed. assoc. with congest. card. fail.
hepat. cirrh. Hypertens: as sole ther.
agent or to enhance effectiveness of
other antihypertens. drugs.
C/I: Anuria, severe progress. renal dis.,
acute renal fail., elevated serum potass.
levels, hypersens. to any of compon.
