All the Therapeutic System Drugs
CGRP, Human Monoclonal Antibody. Erenumab 70 mg. PRE-FILL. SYR (sol. for S.C. inj.): 1
PRE- FIL. PEN (sol. for S.C. inj.): 1
Tmt. is intend. for pts. with at least 4 migraine days per month when initiat. tmt. with erenumab.
The recomm. dose is 70 mg erenumab every 4 wks. Some pts. may benefit from a dose of 140 mg every 4 wks.
Each 140 mg dose is given as two S.C. inj. of 70 mg. See lit.
Tmt. should be initiat. by physicians experienced in the diagnosis and tmt. of migraine.
CGRP Antagonist, Monoclonal Antibody. Fremanezumab 225 mg. PREFILLED SYR (sol. for SC inj.): 1,3× 1.5ml. Tmt. is intended for pts. with at least 4 migraine days/month when initiat. tmt. with fremanezumab.
Two dosing options are available:
225 mg once mnthly. (mnthly. dosing) or 675 mg every three mnths. (quarterly dosing).
When switching dosing regimens, the first dose of the new regimen should be admin. on the next scheduled dosing date of the prior regimen.
When initiat. tmt. with fremanezumab, concom. migraine prevent. tmt. may be continued if consid. necessary by the prescriber.
The tmt. benefit should be assessed within 3 mnths. after init. of tmt. Any further decision to continue tmt. should be taken on an individ. pt. basis. Evaluation of the need to continue tmt. is recomm. regularly thereafter.
Missed dose: If a fremanezumab inject. is missed on the planned date, dosing should resume as soon as possible on the indicated dose and regimen. A double dose must not be admin. to make up for a missed dose.
Indicat. for prophylaxis of migraine in adult. who have at least 4 migraine days per month.
5-HT1 Agonist. Eletriptan (As Hydrobromide) 40 mg, 80 mg. F.C. TABS: 3, 10x40 mg, 3x80 mg. Intend. for pts. over the age of 18 & under the age of 65. Can be taken at any stage after the migraine pain appears, but it is best to do so as soon as possible. The usual init. dose is 40 mg tab. If after the 1st tab. ther is no relief, 2nd tab. should not be taken for the same attack. If after a 1st tab. the migraine is relieved and then comes back, 2nd tab. may be taken. However there has to be at least 2 hrs. wait. before taking the 2nd tab. See lit.
Acute tmt. of the headache phase of migraine attacks, with/without aura.
C/I: Hypersens. Cardiovascular disord. Pts. with hep./ren. impair. History/present moder.-severe hypertens. Pts. with mild untreat. hypertens. Pts. with history of CVA. Concom. use with ketoconazole, itraconazole (for treat. fung. infect.), erythromycin, clarithromycin, josamycin, ritonavir, indinavir, nelfinavir, and other 5HT1 serotonin receptor agon. Concom. use with ergot alkal. within 2 hrs before or after taking this drug. Pts. hereditary problem of intoler. to galactose, Lapp lactase defic., or impair. absorpt. of glucose/galactose.
5-HT1 Agonist. Sumatriptan (as succinate) 50 mg, 100 mg. TABS: 2, 6 x 50 mg, 100 mg. 1 tab of 50
mg. Some pts. may require 1 tab of 100
mg. If sympt. recur: 1 tab. aft. at least 2
hrs. Pts. who fail to respond initially
should not receive second dose for
same attack. Max. dose: 3 tabs (300
mg) in 24 hrs.
Acute relief of migraine attacks, with or
w/o aura, should only be used where there
is a clear diagnosis of migraine.
C/I: Hypersens.; Pts. with hist. of MI or
have ischaem. heart dis., coron.
vasospasm (Prinzmetal’s ang.), periph. vasc. dis. or sympt. or signs consistent
with ischaem. heart dis.;
Pts. with a hist. of CVA or TIA; Pts. with
severe hep. impair.; Pts. with moder./
severe HTN. and mild uncontrol. HTN;
concom. admin.of ergotamine, or
derivate. of ergotamine (includ.
methysergide) or any triptan/5-HT1
receptor agon.; Concur. admin. with
MAOIs. Must not be used within 2 wks.
of discount. of ther. with MAOIs.