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  • Pulmonary Hypertension
    9 Drugs classified under this therapeutic system

    All the Therapeutic System Drugs

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    Flolan Infusion Of Epoprestenol 500 mcg, 1500 mcg
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    Flolan Infusion Of Epoprestenol 500 mcg, 1500 mcg

    Prostaglandin. Epoprostenol (as sodium) 0.5 mg, 1.5 mg.
    VIAL (freeze-dried pwdr.): 1 + 1 sterile
    diluent. See lit.
    Long-term I.V. tmt. prim. pulm.
    hypertens. in NYHA class III and IV.

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    Synthetic Prostacyclin Analog. Treprostinil (as Sodium) 2.5 mg, 5 mg, 10 mg/ml.
    VIAL: 1, 5 × 20 ml of 50 mg, 100mg,
    200mg. SC or IV use contin. infus. The
    infus. rate is init. at 1.25 ng/kg/min. If
    this init. dose cannot be tolerat., the
    infuse. rate should be reduced to 0.625
    ng/kg/min. See lit.
    Prim. pulmon. arter. hypertens.
    Pulmon. arter. hypertens. assoc. with
    connect. tissue disord.
    Pulmon. arter. hypertens. assoc. with
    congen. system. to pulmon. shunts.
    C/I: Hypersens. to the drug or structural.
    related compound.

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    PDE5 Inhibitor. Sildenafil (as citrate) 20 mg.
    F.C. TABS: 90. 20 mg 3 x dly approx.
    4-6 hrs apart, with/out food. See lit.
    For adult. > 18 yrs.: Tmt. of prim.
    pulmon. hypertens. (PPH) pulm.
    hypertens. (PH) associated with
    connective tissue disease (CTD) or PH
    following surgical repair at least 5 yrs.
    previous. of atrial septal defect (ASD)
    ventric. septal defect (VSD) patent
    ductus arteriosus (PDA) or aortopulmon.
    C/I: Hypersens; Co-admin. with nitric
    oxide donors (such as amyl nitrite) or
    nitrates in any form due to the
    hypotensive effects of nitrates.
    Co-admin. of PDE5 inhib., includ.
    sildenafil, with guanylate cyclase
    stimulat; Comb. with the most potent of
    the CYP3A4 inhib. (eg, ketoconazole,
    itraconazole, ritonavir).
    Pts. who have loss of vision in one eye
    because of non-arteritic anterior
    ischaem. optic neuropathy (NAION),
    regardless of whether this episode was
    in connect. or not with prev. PDE5 inhib.
    expos; Sev. hep. impair; Recent history
    of stroke or MI; Severe hypotens. (blood
    pres.< 90/50 mmHg) at initiat.

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    PDE5 Inhibitor. Sildenafil (as citrate) 20 mg.
    TABS: 90 x 20 mg. 20 mg 3 x dly approx.
    4-6 hrs apart, with/out food. Higher
    than 20 mg not recommend.
    Tmt. prim. pulm. hypertens. (PPH), pulm.
    hypertens (PH) assoc. with connect. tissue dis. (CTD) or PH foll. surg. repair atrial septal
    defect (ASD) at least 5 yrs previously, ventric. septal defect (VSD), patent ductus arteriosus (PDA) or aorto-pulm. window. For adults >18 yrs.
    C/I: Organ. nitrates (regular/ intermittent
    use) in any form, known hypersens.,
    veno-occlus. dis.

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    PDE5 Inhibitor. Tadalafil 20 mg.
    TABS.: 56. 1 tab.×1/d.
    Indic. adults for the tmt.  of pulmon. arterial hypertens.  classified as WHO funct.  class II and III, to improve exercise capacity. Efficacy has been shown in idiopathic PAH (IPAH) and in PAH related to collagen vascular dis.
    C/I: Concom. use with nitrates. History or presence of  loss of vision as a result of NAION - non-arteritic anterior ischemic optic neuropathy. MI  in the last 3 mnths. Hypotens. Concom. use with riociguat.

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    Endothelin Receptor Antagonist. Bosentan 62.5 mg, 125 mg.
    F.C. TABS: 60 x 62.5 mg, 125 mg. Initial:
    62.5 mg 2 x dly for 4 wks. Maint: 125 mg
    2 x dly morn. and even. with or without
    Prim. pulm. arterial hypertens. or second.
    to scleroderma or other connect. tissue
    dis. Reduct. number new digital ulcs. in
    system. sclerosis, ongoing digital ulc. dis.
    C/I: Pregn.

    Other therapeutic systems under Cardiovascular System