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  • Pulmonary Hypertension
    11 Drugs classified under this therapeutic system


    All the Therapeutic System Drugs

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    Flolan Infusion Of Epoprestenol 500 mcg, 1500 mcg
    GSK
    RX
    partial basket chart
    Flolan Infusion Of Epoprestenol 500 mcg, 1500 mcg

    Prostaglandin. Epoprostenol (as sodium) 0.5 mg, 1.5 mg.
    VIAL (freeze-dried pwdr.): 1 + 1 sterile
    diluent. See lit.
    Long-term I.V. tmt. prim. pulm.
    hypertens. in NYHA class III and IV.

    Opsumit
    Janssen
    RX
    partial basket chart
    Opsumit

    Endothelin Receptor Antagonist. Macitentan 10 mg.
    F.C. TABS.: 30. 10 mg ×1/d, with or without food, should be taken every day at the same time.
    Tmt. of PAH, who GROUP I to delay dis. progress. Dis. progress. includ.: death, initiat. of IV or subcutan. prostanoids, or clin. worsening of PAH (decreased 6-min. walk distance, worsened PAH sympt. and need for additional PAH tmt.). The drug also reduced hospitaliz. for PAH.
    C/I: Hypersens., Soya. Preg., WOCBP who are not using reliable contracep., Lact.
    Pts. with severe hep. impair. (with or without cirrhosis).
    Baseline values of hep. aminotransferases (AST and/or ALT>3×ULN).

    Remodulin
    Rafa
    RX
    partial basket chart
    Remodulin

    Synthetic Prostacyclin Analog. Treprostinil (as Sodium) 2.5 mg, 5 mg, 10 mg/ml.
    VIAL: 1, 5 × 20 ml of 50 mg, 100mg,
    200mg. SC or IV use contin. infus. The
    infus. rate is init. at 1.25 ng/kg/min. If
    this init. dose cannot be tolerat., the
    infuse. rate should be reduced to 0.625
    ng/kg/min. See lit.
    Prim. pulmon. arter. hypertens.
    Pulmon. arter. hypertens. assoc. with
    connect. tissue disord.
    Pulmon. arter. hypertens. assoc. with
    congen. system. to pulmon. shunts.
    C/I: Hypersens. to the drug or structural.
    related compound.

    Revatio
    Pfizer
    RX
    partial basket chart
    Revatio

    PDE5 Inhibitor. Sildenafil (as citrate) 20 mg.
    F.C. TABS: 90. 20 mg 3 x dly approx.
    4-6 hrs apart, with/out food. See lit.
    For adult. > 18 yrs.: Tmt. of prim.
    pulmon. hypertens. (PPH) pulm.
    hypertens. (PH) associated with
    connective tissue disease (CTD) or PH
    following surgical repair at least 5 yrs.
    previous. of atrial septal defect (ASD)
    ventric. septal defect (VSD) patent
    ductus arteriosus (PDA) or aortopulmon.
    window.
    C/I: Hypersens; Co-admin. with nitric
    oxide donors (such as amyl nitrite) or
    nitrates in any form due to the
    hypotensive effects of nitrates.
    Co-admin. of PDE5 inhib., includ.
    sildenafil, with guanylate cyclase
    stimulat; Comb. with the most potent of
    the CYP3A4 inhib. (eg, ketoconazole,
    itraconazole, ritonavir).
    Pts. who have loss of vision in one eye
    because of non-arteritic anterior
    ischaem. optic neuropathy (NAION),
    regardless of whether this episode was
    in connect. or not with prev. PDE5 inhib.
    expos; Sev. hep. impair; Recent history
    of stroke or MI; Severe hypotens. (blood
    pres.< 90/50 mmHg) at initiat.

    Slider
    Unipharm
    RX
    partial basket chart
    Slider

    PDE5 Inhibitor. Sildenafil (as citrate) 20 mg.
    TABS: 90 x 20 mg. 20 mg 3 x dly approx.
    4-6 hrs apart, with/out food. Higher
    than 20 mg not recommend.
    Tmt. prim. pulm. hypertens. (PPH), pulm.
    hypertens (PH) assoc. with connect. tissue dis. (CTD) or PH foll. surg. repair atrial septal
    defect (ASD) at least 5 yrs previously, ventric. septal defect (VSD), patent ductus arteriosus (PDA) or aorto-pulm. window. For adults >18 yrs.
    C/I: Organ. nitrates (regular/ intermittent
    use) in any form, known hypersens.,
    veno-occlus. dis.


    Other therapeutic systems under Cardiovascular System

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