All the Active Ingredient Drugs
Endothelin Receptor Antagonist. Bosentan (as monohydrate) 62.5 mg, 125 mg. F.C. TABS.: 60. The tmt. in adults is usually started with 62.5 mg ×2/d for the first 4 wks. Thereafter, the dose may be incr. to 125 mg×2/d, depend. on the react. of the pt.
Child. and adolesc.: The optimal dosage for child. under the age of 12 who suffer from pulmon. arterial hypertens. is unknown.
Treatment of pulmonary arterial hypertension (PAH) in patients of WHO functional class II-IV.
Reduct. in the number of new digital ulcers in pts. with system. sclerosis with active digital ulcer dis.
C/I: Hypersens. Hepat. impair. Women of child bear. age who are not use. appropr. method of contracep. Preg. Transplant/proriatic pts. who are treated with cyclosporine. See lit.
Endothelin Receptor Antagonist. Bosentan 62.5 mg, 125 mg. F.C. TABS: 60 x 62.5 mg, 125 mg. Initial:
62.5 mg 2 x dly for 4 wks. Maint: 125 mg
2 x dly morn. and even. with or without
Prim. pulm. arterial hypertens. or second.
to scleroderma or other connect. tissue
dis. Reduct. number new digital ulcs. in
system. sclerosis, ongoing digital ulc. dis.