All the Active Ingredient Drugs
Endothelin Receptor Antagonist. Macitentan 10 mg. F.C. TABS.: 30. 10 mg ×1/d, with or without food, should be taken every day at the same time.
Tmt. of PAH, who GROUP I to delay dis. progress. Dis. progress. includ.: death, initiat. of IV or subcutan. prostanoids, or clin. worsening of PAH (decreased 6-min. walk distance, worsened PAH sympt. and need for additional PAH tmt.). The drug also reduced hospitaliz. for PAH.
C/I: Hypersens., Soya. Preg., WOCBP who are not using reliable contracep., Lact.
Pts. with severe hep. impair. (with or without cirrhosis).
Baseline values of hep. aminotransferases (AST and/or ALT>3×ULN).