Antianginals

23 Drugs classified under this therapeutic system

Calcium Channel Blocker, Class IV Antiarrhythmic. Diltiazem (as HCl) 120, 180, 240 mg.
C.R. CAPS: 30 x 120 mg, 180 mg, 240 mg.
Usual start. dose: 240 mg 1 x dly. All
strengths 1 x dly. See lit.
Chron. stable ang. pect., ang. due to
coronary art. spasm, hypertens.
C/I: Sick-sinus syndr., 2nd or 3rd degree
AV block (unless funct. ventric.
pacemaker present), severe bradycard.,
severe heart fail., severe hypotens. (syst.
press. < 90 mm Hg), acute M.I.,
radiograph. pulm. congest.

Calcium Channel Blocker. Amlodipine Besylate 5 mg, 10 mg.
TAB: 20, 30. Hypertens. and angina: Initial.
5 mg dly, may incr. to max dly dose of
10 mg depend. on pt. response.
Dose titrat. can proceed over 7-14 days
but may proceed more rapidly if clinic.
warranted. No dose adjust. reqd. when
used tog. with thiazide diuret.,
ß-blockers and ACE inhibits. Elderly: As
in younger pts. Child: Safety and effect.
have not been established.
Mild to mod. hypertens., chron. stable
ang., confirmed or susp. vasospastic ang.
(Prinzmetal’s or variant ang.). May be
used alone or in combin. with other
antihypertens. or antiang. agents.

Calcium Channel Blocker. Amlodipine Maleate 5 mg, 10 mg.
TABS: 20. Initial: 5 mg 1 x dly. May incr.
to max. 10 mg dly depend. on pt.
response. Elderly and young pts:
Normal dosage regimen.
Mild to mod. hypertens., vasospastic
angina (Prinzmetal’s or variant angina),
chronic stable angina.

β1 Blocker. Bisoprolol Fumarate 2.5, 5, 10 mg.
F.C. TABS.: 7, 10, 14, 20, 28, 30, 56, 60, 90,
500. Depend. on the dis. and the pt. cond.,
2.5 mg -10 mg×1/d. Max. recom. dose 20 mg×1/d.
2.5 mg tabs: Stable, chron., moder.- severe
HF. 5 mg , 10 mg tabs: Hypertens, CHD
(ang. pect.).
C/I: 2nd, 3rd degree AV block. Sinus
bradyc. Sick sinus syndr. Severe periph.
arter. dis. Printzmetal’s angina,
uncompens. card. fail. (except
carvedilol), cardiog. shock, hypotens.,
right ventr.fail. second. to pulmon.
hyperten., significant cardiomeg.
Untreat. phaeochromocytoma, metab.
acidosis. Non-cardiosel. β-block.
(nadolol, oxprenolol, penbutolol,
pindolol, propranolol, timolol) are also
generally contraind.in pts. with obstruct.
airways dis. or a history of
bronchospasm.

β1 Blocker. Bisoprolol Fumarate 1.25, 2.5, 5, 10 mg.
TABS: 30x1.25,2.5 mg. Initial (with uptitrat.): 1.25 mg 1 x dly for 1 wk. If well tolerat. incr. to 2.5 mg 1 x dly for another wk. If well tolerat. incr. to 5 mg 1 x dly the foll. 4 wks. If well tolerat. incr. to 7.5 mg 1 x dly the foll. 4 wks. If well tolerat. incr.
to 10 mg 1 dly for maint. ther.
Stable chron. heart fail.
TABS: 30x5,10 mg. 5-10 mg dly.
Hypertens., ang. pect.
C/I: Hypersens., pregn., lact.

β1 Blocker. Bisoprolol Fumarate 1.25 mg, 2.5 mg , 5 mg, 10 mg.
FC tabs, 30X1.25/2.5/5/10 mg. Dosage for Chron. Heart Fail.:start uptitr.:
- 1.25 mg 1/d for 1 week, if well tol. incr. to
- 2.5 mg 1/d for a further week, if well tol. incr. to
- 3.75 mg 1/d for a further week, if well tol. incr. to
- 5 mg 1/d for 4 foll. weeks, if well tol. incr. to
- 7.5 mg 1/d for 4 foll. weeks, if well tol. incr. to
- 10 mg 1/d for maint. ther. (max recomm. dose.)
Dosage for Hypertension: 2.5-10 mg 1/d, see lit.
Dosage for Coronary heart dis. (angina pect.):5-10 mg 1/d
max. recomm. dose: 20 mg/d
Treat. of stable chr., moder. to sev. heart fail.
with impaired systol. ventric. function
(EF < 35 %, by echocardiography) in addit.
to ACE inhibit. and diuret., and option. cardiac glycosides.
For 5mg and 10 mg doses:
Hypertension
Coronary heart disease (angina pectoris)
C/I: ac. HF or during episodes of decompens. req. i.v. inotropic ther./ cardiogenic shock /second or third degree AV block /sick sinus syndr./ sinoatrial block/ sympt. bradyc./ sympt. hypotens. / sev. bronchial asthma / sev. forms of peripheral arterial occlusive dis. or sev. forms of Raynaud's syndr./
untreat. phaeochromocytoma (see prescr. inform.) / metabolic acidosis/ hypersens.