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  • Reactants on Vascular System
    9 Drugs classified under this therapeutic system


    All the Therapeutic System Drugs

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    Adempas
    Bayer
    RX
    partial basket chart
    Adempas

    Soluble Guanylate Cyclase Stimulator. Riociguat 0.5, 1, 1.5, 2, 2.5 mg.
    F.C. TABS.: 42×0.5mg, 1mg, 1.5mg, 42, 84×2mg, 84×2.5mg. The recomm. start. dose is 1 mg×3/d for 2 wks. approx. 6 to 8 hrs. apart. incr. by 0.5 mg×3/d every two wks. to a max. of 2.5 ×3/d, if systole. blood press. is ≥95 mmHg and the pt. has no signs or sympt. of hypotens.
    Maint.dose The max. total dly. dose is 7.5 mg i.e., 2.5 mg ×3/d. If a dose is missed, tmt. should be cont. with the next dose as planned. See lit.
    CTEPH, Pts. with WHO Funct. class II to III: Inoperable CTEPH, Persist./ recur. CTEPH after surg. tmt., to improve exercise capacity. PAH: as monother. /combination with endothelin receptor antag., tmt. of adult pts. with PAH with WHO Funct. class II to III to improve exercise capacity. Effic.has been shown in a PAH population including aetiologies of idiopathic or heritable PAH or PAH assoc. with connect. tissue dis.
    C/I: Hypersens. Co-adm. with PDE 5 inhib. (e.g sildenafil, tadalafil, vardenafil). Sev. hep. impair. (Child Pugh C). Co-adm. with nitrates or nitric oxide donors (e.g. amyl nitrite) in any form. Pts. with systolic
    blood pressure < 95 mm Hg at tmt. init.

    Hyalase
    Propharm
    RX
    partial basket chart
    Hyalase

    Hyaluronidase 1,500 IU/dose.
    AMPS: 10, 100. See lit.
    Enhance. permeat. S.C. or I.M. inject.,
    local anesthet., S.C. infus., promot.
    resorpt. excess fluids and blood in tissues.
    C/I: Hypersens., unexplain. prem. labour,
    reduct. swelling of bites, stings, sites
    where infect. or malign. present.

    Ilomedin
    Bayer
    RX
    partial basket chart
    Ilomedin

    Prostaglandin. Iloprost 0.1 mg/ml.
    AMPS (Conc. sol. for infus.): 0.5 ml.
    See lit.
    Periph. art. occlus. dis. (stage III and IV)
    in adv. arterioscler., diabet. angiopath.,
    thromboangit. obliterans (Buerger’s dis.),
    Raynaud’s syndr.
    C/I: Pregn., lact., hypersens. to compon.,
    where effect of drug on platelets might
    incr. risk of hemorrh., (e.g., active pept.
    ulc., trauma, intracran. hemorrh.), severe
    coron. heart dis., unstable ang., M.I.
    within last 6 mths., acute or chron.
    congest. heart fail., severe arrhyth.
    suspect. pulm. congest.

    Levophed
    Pfizer
    RX
    not in the basket chart
    Levophed

    Sympathomimetic. Norepinephrine Bitartrate 1 mg/ml.
    AMPS: 10 x 4 ml x 1 mg/ml. See lit.
    BP control in certain acute hypotens.
    states, adjuv. in card. arrest, profound
    hypotens.
    C/I: Hypotens. caused by blood vol.
    deficits, messenteric or periph. vasc.
    thromb., during cyclopropane or
    halothane anesth. See lit.

    Opsumit
    Actelion
    RX
    partial basket chart
    Opsumit

    Endothelin Receptor Antagonist. Macitentan 10 mg.
    F.C. TABS.: 30. 10 mg ×1/d, with or
    without food, should be taken every
    day at the same time.
    Tmt. of PAH, who GROUP I to delay dis.
    progress. Dis. progress. includ. : death,
    initiat. of IV or subcutan. prostanoids, or
    clin. worsening of PAH (decreased 6-min.
    walk distance, worsened PAH sympt. and
    need for additional PAH tmt.). The drug
    also reduced hospitaliz. for PAH.
    C/I: Hypersens., Preg., WOCBP who are
    not using reliable contracep., Lact. Pts.
    with severe hep. impair. (with or without
    cirrhosis). Baseline values of hep.
    aminotransferases (AST and/or ALT > 3 ×
    ULN).


    Other therapeutic systems under Cardiovascular System

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