All the Drug Class Drugs
Soluble Guanylate Cyclase Stimulator. Riociguat 0.5, 1, 1.5, 2, 2.5 mg. F.C. TABS.: 42×0.5mg, 1mg, 1.5mg, 42, 84×2mg, 84×2.5mg. The recomm. start. dose is 1 mg×3/d for 2 wks. approx. 6 to 8 hrs. apart. incr. by 0.5 mg×3/d every two wks. to a max. of 2.5 ×3/d, if systole. blood press. is ≥95 mmHg and the pt. has no signs or sympt. of hypotens.
Maint.dose The max. total dly. dose is 7.5 mg i.e., 2.5 mg ×3/d. If a dose is missed, tmt. should be cont. with the next dose as planned. See lit.
CTEPH, Pts. with WHO Funct. class II to III: Inoperable CTEPH, Persist./ recur. CTEPH after surg. tmt., to improve exercise capacity. PAH: as monother. /combination with endothelin receptor antag., tmt. of adult pts. with PAH with WHO Funct. class II to III to improve exercise capacity. Effic.has been shown in a PAH population including aetiologies of idiopathic or heritable PAH or PAH assoc. with connect. tissue dis.
C/I: Hypersens. Co-adm. with PDE 5 inhib. (e.g sildenafil, tadalafil, vardenafil). Sev. hep. impair. (Child Pugh C). Co-adm. with nitrates or nitric oxide donors (e.g. amyl nitrite) in any form. Pts. with systolic
blood pressure < 95 mm Hg at tmt. init.
Soluble Guanylate Cyclase Stimulator. Vericiguat 2.5 mg , 5 mg , 10 mg. FC Tabs:14/28/98 X 2.5/5/10 mg: . 2.5 mg vericiguat once daily. Dose to be doubl. approx every 2 weeks to reach maint. dose of 10 mg once daily, as toler. See full prescript. info
To red. the risk of cardiovascular death and heart failure (HF) hospital. following a hospital. for HF or need for outpatient IV diuretics, in adults with sympt. chron. HF and EF less than 45%.
C/I:Hypersens, Concom. use of other sol. guanylate cyclase (sGC) stim., such as riociguat
