• Home
  • A-B index
  • Pharmacological Index
  • Drug Classes
  • Active Ingredients
  • Companies
  • News
  • Soluble Guanylate Cyclase Stimulator
    1 Drug classified under this drug class


    All the Drug Class Drugs

    Adempas
    Bayer
    RX
    partial basket chart
    Adempas

    Soluble Guanylate Cyclase Stimulator. Riociguat 0.5, 1, 1.5, 2, 2.5 mg.
    F.C. TABS.: 42×0.5mg, 1mg, 1.5mg, 42, 84×2mg, 84×2.5mg. The recomm. start. dose is 1 mg×3/d for 2 wks. approx. 6 to 8 hrs. apart. incr. by 0.5 mg×3/d every two wks. to a max. of 2.5 ×3/d, if systole. blood press. is ≥95 mmHg and the pt. has no signs or sympt. of hypotens.
    Maint.dose The max. total dly. dose is 7.5 mg i.e., 2.5 mg ×3/d. If a dose is missed, tmt. should be cont. with the next dose as planned. See lit.
    CTEPH, Pts. with WHO Funct. class II to III: Inoperable CTEPH, Persist./ recur. CTEPH after surg. tmt., to improve exercise capacity. PAH: as monother. /combination with endothelin receptor antag., tmt. of adult pts. with PAH with WHO Funct. class II to III to improve exercise capacity. Effic.has been shown in a PAH population including aetiologies of idiopathic or heritable PAH or PAH assoc. with connect. tissue dis.
    C/I: Hypersens. Co-adm. with PDE 5 inhib. (e.g sildenafil, tadalafil, vardenafil). Sev. hep. impair. (Child Pugh C). Co-adm. with nitrates or nitric oxide donors (e.g. amyl nitrite) in any form. Pts. with systolic
    blood pressure < 95 mm Hg at tmt. init.

    CLOSE