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  • Soluble Guanylate Cyclase Stimulator
    1 Drug classified under this drug class

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    partial basket chart

    Soluble Guanylate Cyclase Stimulator. Riociguat 0.5, 1, 1.5, 2, 2.5 mg.
    F.C. TABS.: 42×0.5mg, 1mg, 1.5mg, 42, 84×2mg, 84×2.5mg. The recomm. start. dose is 1 mg×3/d for 2 wks. approx. 6 to 8 hrs. apart. incr. by 0.5 mg×3/d every two wks. to a max. of 2.5 ×3/d, if systole. blood press. is ≥95 mmHg and the pt. has no signs or sympt. of hypotens.
    Maint.dose The max. total dly. dose is 7.5 mg i.e., 2.5 mg ×3/d. If a dose is missed, tmt. should be cont. with the next dose as planned. See lit.
    CTEPH, Pts. with WHO Funct. class II to III: Inoperable CTEPH, Persist./ recur. CTEPH after surg. tmt., to improve exercise capacity. PAH: as monother. /combination with endothelin receptor antag., tmt. of adult pts. with PAH with WHO Funct. class II to III to improve exercise capacity. Effic.has been shown in a PAH population including aetiologies of idiopathic or heritable PAH or PAH assoc. with connect. tissue dis.
    C/I: Hypersens. Co-adm. with PDE 5 inhib. (e.g sildenafil, tadalafil, vardenafil). Sev. hep. impair. (Child Pugh C). Co-adm. with nitrates or nitric oxide donors (e.g. amyl nitrite) in any form. Pts. with systolic
    blood pressure < 95 mm Hg at tmt. init.