All the Therapeutic System Drugs
Omega-3 300 mg (DHA 120 mg, EPA 180 mg). CAPS: 210. 1 cap dly, dur.
meal.
Nutritional supplement.
C/I: Hypersens.
Omega-3 600 mg. CAPS: 120. 1-3 caps dly, dur. meal.
Nutritional supplement.
C/I: Hypersens.
HMG-CoA Reductase Inhibitor, Lipid Modifying Agent. Ezetimibe 10 mg, Atorvastatin 10, 20, 40, 80 mg. F.C. TABS.: 30. Hypercholesterolaemia and/or CHD with ACS History). The pt. should be on an appropriate lipid-lower. diet and should cont. on this diet during tmt. with this drug.
The dose range is 10/10 mg/d. through 10/80 mg/d. The typical dose is 10/10 mg ×1/d. The pt’s. low-density lipoprotein cholesterol (LDL-C) level, CHD status, and response to current cholesterol-lower. ther. should be consid. when starting ther. or adjust. the dose.
The dose should be individual. based on the known efficacy of the various dose strengths of and the response to the current cholesterol-lower. ther. Adjust. of dose should be made at intervals of 4 wks. or more.
HoFH: 10/10-10/80 mg dly. The drug may be used as an adjunct to other lipid-lower. tmts. (e.g., LDL apheresis) in these pts. or if such tms. are unavailab.
May be taken with/without food.
Prevent. of Cardiovasc. Event: Indicat. to reduce the risk of cardiovasc. events in pts. with coron. heart dis.(CHD) and a hist. of acute coron. syndr. (ACS), either previous. treated with a statin or not.
Hypercholesterolaemia: The drug indicat. as adjunct. ther. to diet for use in adult. with prim. (heterozygous famil. and non-famil.) hypercholesterolaemia or mixed hyperlipidaemia where use of a comb. product is appropriate, pts. not appropriat. control. with a statin alone, pts. already treated with a statin and ezetimibe.
Homozyg. Familial Hypercholesterolaemia (HoFH): Indicat. as adjunct. ther. to diet for use in adults with HoFH. Pts. may also receive adjunct. tmts. (e.g., low-density lipoprotein [LDL] apheresis).
C/I: Hypersens. Preg., lact. , and in women of child-bear. potent.
Fibrate. Bezafibrate 400 mg. S.R. TABS: 30. 1 tab dly in even.
Hyperlipidem. in types 11a, 11b, III, IV, V
where diet alone is insuffic.
C/I: Hypersens., pregn., lact., liver/
gallbladder dis., severe renal funct.
disords.
Fibrate. Bezafibrate 400 mg. SR Tab. 30 X 400 mg
One tablet, to be swallowed whole with suffic. fluid after a meal either in the
morning or at night.
Adjunct to diet and other non- pharmacological
tmt. (e.g. exercise, weight reduct.) for
the tmt. of sev. hypertriglyceridaemia
C/I: Hypersens. – Signif. hepatic dis. (other than fatty infiltr. of the liver assoc. with raised triglyceride values).
- Gall-bladder dis. with or without cholelithiasis.
- Pts. with nephrotic syndr. and sev. renal fail. (serum creatinine > 135μmol/l; creatinine clear.<60ml/min) and pts. undergoing dialysis.
- Combin. ther. (concom. use) of bezafibrate with HMG CoA reductase inhibit. (statins) in pts. with predisposing factors for myopathy.
- Known photoallergic or phototoxic reactions to fibrates.
Statin. Rosuvastatin (as Calcium) 5, 10, 20, 40 mg. TABS: 28 x 5mg, 10 mg, 20 mg, 40
mg. Not to be chewed, crushed or
divided. May be given at any time of the
day, with or without food. Bef. tmt.
initiat. pt. to be on a standard
cholesterol-lower. diet that should
contin. dur. tmt. Individual. accord. to
the goal of the ther. and pt.
response. Start dose: 10 mg 1 x dly. Dose
adjust. to 20 mg can be made after 4 wks if necess. 40 mg only in pts. with
severe hypercholesterolem. at high CV
risk who do not achieve their tmt. goal
on 20 mg. Follow-up routine to be
performed. Not recommend. for ped.
No dos adjust. necess in elderly, or pts.
with mild to mod. ren. impair. Hepat.
impair. pts. with Child-Pugh scores of 8
and 9: Assess. of ren. funct. should be
considered.
Prim. hypercholesterolem. (type IIa incl.
heterozygous famil.
hypercholesterolem.) or mixed
dyslipidem. (type IIb) as an adjunct to
diet when response to diet and other
non-pharmacolog. tmts. (e.g exercise,
wt. reduct.) is inad. Homozygous famil.
hypercholesterolem. as an adjunct to
diet and other lipid lower. tmts (e.g. LDL
apheres.) or if such tmts. not approp.
C/I: Hypersens. to rosuvastatin or to any of
the excips.; active liver dis. incl.
unexplain., persist. elevat. serum
transaminases and any serum
transaminase elevat. exceed. 3 x the
upper limit of normal (ULN); severe ren.
impair. (creatinine clear. <30ml/min);
myopath. pts. receiv. concom.
cyclosporin; pregn., lact., women of
childbearing potential not using approp.
contracept. measures.
