All the Drug Class Drugs
Human Monoclonal Antibody. Evolocumab 140 mg/ml. PRE-FILL.PEN.: 1, 2, 3, 6. Prim.
hypercholesterolaemia & mixed
dyslipidaemia in adults: 140 mg every
two wks. or 420 mg once mnthly.; both
doses are clinic.equival.
Homozyg. fam. hypercholesterolaemia
in adults & adolesc. aged 12 yrs. and
over: Initial. 420 mg once monthly.
After 12 wks. of tmt., dose frequen. can
be up titrated to 420 mg once every 2
wks. if a clinic. meaningful response is
not achieved. Pts. on apheresis may
init. tmt. with 420 mg every two wks. to
corresp.with their apheresis schedule.
Hypercholesterolaemia & mixed
famil. & non famil.) or mixed
dyslipidaemia in adult., as an adjunct to
diet: In comb. with a statin or statin with
other lipid low. therap. in pts. unable to
reach LDL C goals with the max.
tolerated dose of a statin or, Alone or in
comb.with other lipid-low. therap. in pts.
who are statin-intolerant/ for whom a
statin is contraind. Homozyg. famil.
hypercholesterolaemia in adults &
adolesc. aged 12 yrs. and over with
homozyg. famil. hypercholesterolaemia
in comb. with other lipid-low. therap.. The
effect of Evolocumab on cardiovasc.
morbidity & mortal. has not yet been