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  • Human Monoclonal Antibody
    1 Drug classified under this drug class

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    Human Monoclonal Antibody. Evolocumab 140 mg/ml.
    PRE-FILL.PEN.: 1, 2, 3, 6. Prim.
    hypercholesterolaemia & mixed
    dyslipidaemia in adults: 140 mg every
    two wks. or 420 mg once mnthly.; both
    doses are clinic.equival.
    Homozyg. fam. hypercholesterolaemia
    in adults & adolesc. aged 12 yrs. and
    over: Initial. 420 mg once monthly.
    After 12 wks. of tmt., dose frequen. can
    be up titrated to 420 mg once every 2
    wks. if a clinic. meaningful response is
    not achieved. Pts. on apheresis may
    init. tmt. with 420 mg every two wks. to
    corresp.with their apheresis schedule.
    Hypercholesterolaemia & mixed
    dyslipidaemia. Primary
    hypercholesterolaemia (heterozygous
    famil. & non famil.) or mixed
    dyslipidaemia in adult., as an adjunct to
    diet: In comb. with a statin or statin with
    other lipid low. therap. in pts. unable to
    reach LDL C goals with the max.
    tolerated dose of a statin or, Alone or in
    comb.with other lipid-low. therap. in pts.
    who are statin-intolerant/ for whom a
    statin is contraind. Homozyg. famil.
    hypercholesterolaemia in adults &
    adolesc. aged 12 yrs. and over with
    homozyg. famil. hypercholesterolaemia
    in comb. with other lipid-low. therap.. The
    effect of Evolocumab on cardiovasc.
    morbidity & mortal. has not yet been
    C/I: Hypersens.