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  • Evolocumab
    1 Drug classified under this active ingredient


    All the Active Ingredient Drugs

    Repatha
    Amgen
    RX
    partial basket chart
    Repatha

    Human Monoclonal Antibody. Evolocumab 140 mg/ml.
    PRE-FILL.SYR.: 1, 2, 3, 6. Prim. hypercholesterolem & mixed dyslipidem. in adult.: either 140 mg every two wks. or 420 mg once month.; both doses are clinic. equiv.
    Homozyg. famil. hypercholesterolem. in adult. and adolesc. ≥ 12 yrs.: The init. recomm. dose is 420 mg once month. After 12 wks. of tmt., dose frequency can be up-titrated to 420 mg once every 2 wks. if a clinic. meaningful response is not achieved. Pts. on apheresis may initiate tmt. with 420 mg every two wks. to corresp. with their apheresis schedule.
    Establish. atherosclerotic cardiovasc. dis. in adult.: 140 mg every two wks. or 420 mg once month.; both dosesare clinic. equiv.
    Pts. with ren.impair.- pts with mild- moder. ren. impair.,- No dose adjust. is necessary in pts. with severe ren. impair. (eGFR<30 mL/min/1.73 m²).
    Pts. with hep. impair.- No dose adjust. is necessary in pts. with mild hep. impair. See lit.
    Hypercholesterolem. & and mixed dyslipidem., in adults with primary hypercholesterolem. (heterozygous famil. and non-famil.) or mixed dyslipidem., as an adjunct to diet: In comb. with a statin or statin with other lipid-lowering therap. in pts. unable to reach LDL-C goals with the max. tolerated dose of a statin or, alone or in comb. with other lipid-lower. therap. in pts. who are statin-intoler., or for whom a statin is contraindic.
    Homozygous famil. hypercholesterolem.–adult. & adolesc. ≥12 yrs. and over with homozyg. famil. hypercholesterolem. in comb. with other lipid-lower. therap.
    Establish. atherosclerotic cardiovasc. dis.-adults with established atherosclerotic cardiovasc. dis. (MI, stroke or peripher. arterial dis.) to reduce cardiovasc. risk by lower. LDL-C levels, as an adjunct to correct. of other risk factors: In comb. with the maxim. tolerated dose of a statin with/without other lipid-lower. therap.
    Alone or in comb. with other lipid-lower. therap. in pts. who are statin-intoler., or for whom a statin is contraindic.
    C/I: Hypersens.

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