AIDS

40 Drugs classified under this therapeutic system

Antivirals for Treatment of HIV Infections. Efavirenz 600 mg, Emtricitabine 200 mg, Tenofovir Disoproxil 245 mg.
F.C. TABS.: 30. Adults: 1 tab dly on empty stmch. Under 18 yrs: Not recommend. Eldery: use with caution. Not recommend. in pts. with CLcr<50 ml/min. See lit.
For use alone as a complete regimen or in
comb. with other antiretroviral agents for
the tmt of HIV-1 infect. in adults.
C/I: Hypersens. to the product; Sev. hep.
impair. (CPT, Class C); Co-admin. with
terfenadine, astemizole, cisapride,
midazolam, triazolam, pimozide,
bepridil, or ergot alkaloids (for ex.
ergotamine, dihydroergotamine,
ergonovine, methylergonovine).
Co-admin. with voriconazole. Co-admin.
with herbal prep. cont. St. John’s wort
(Hypericum perforatum).

Cannabinoids. THC 0.3, 0.9, 1.5, 3, 4.5, 6 mg/drop, CBD 0.6, 0.9, 1.2, 3, 4.5, 6 mg/drop.
*This product requires a license for medical cannabis.
BOTTLE. (sublingual drop.): 10gr (330 drops). Dosage should be adjust. individual.
The Israel MOH has outlined in Guidance 106 the 12 indicat. for which med. cannabis is indicated. Accord. to this guidance, the 11 indicat. for this product are:
Chemother-induc. nausea and vomit. (CINV)/ chemother induc. pain.
Metastat. cancer pain.
IBD.
Neuropath. pain.
Spastic. of MS.
Pain in Parkinson's dis.
Cachexia in AIDS.
Tourette's syndr.
Recalcitrant epilep. in adult. (Note: Accord. to Guidance 106, med. cannab. is also indic. for recalcitrant epilep. in ped. pts. but this is not an indicat. for this product)
Palliative care for termin. ill pts.
Post- traum. stress disord.
In general, the use of med. cannabis is indicated in pts. who have adequate. tried and failed convent. ther.
Please refer to Guidance 106 for details.
In addition, for an individ. pt. with a clinical. signific. med. condit. that cannot be adequate. managed by convent. ther. and which is not includ. as one of the 12 approved indicat. (eg autism, fibromyalgia), the physician can appeal to the MOH Committee for Med. Cannabis to ask for approval on an individ. exception. basis.
C/I: Prior, current/ family history (1^st degr. relative) of psychos. or schizophr. or schizoaffective disord., a hist. of addict. or substance abuse (include. cannabis use disord.or addict. to alcohol), use in preg.or lact., use in pts. <18 yrs. old, bipol.disord., hypersens. to cannabis, coconut oil, palm kernel oil.
In pts. with hepat. cancer, it is recommend. not to use med. cannab. that contains THC.
See lit.

Antiretrovirals. Bictegravir 50 mg, Emtricitabine 200 mg, Tenofovir Alafenamide 25 mg.
F.C. TABS.: 30. 1 tab×1/d with/without
food. If the patient misses a dose
within 18 hours of the time it is
usually taken, the patient should take
the drug as soon as possible and
resume the normal dosing schedule.
If a patient misses a dose by more
than 18 hours, the patient should not
take the missed dose and simply
resume the usual dosing schedule.
If the patient vomits within 1 hour of
taking the drug another tablet should
be taken. If a patient vomits more
than 1 hour after taking the drug they
do not need to take another dose of
the drug until the next regularly
scheduled dose.
Treatment of adults infected with human
immunodeficiency virus-1 (HIV-1) without
present or past evidence of viral resistance
to the integrase inhibitor class,
emtricitabine or tenofovir.
C/I: Hypersens.
Co-admin. with rifampicin and St John’s
wort (Hypericum perforatum).

Chemokine Receptor Antagonist. Maraviroc 150 mg, 300 mg.
F.C. TABS: 10, 30, 60, 90, 180 x 150 mg,
300 mg. Depend. on interacts. With
co-admin. antiretrovir. ther. and other
medicin. prods. See lit.
In comb. with other antiretrovir. medicin.
prods., for the tmt. experienced adult pts.
infect. with only CCR5-tropic HIV-
1 detectable.
C/I: Hypersens. to active substance or to
peanut, soya or any excips., pts with
severe renal impair. or ESRD (CrCl <30
ml/ min) who take potent CYP3A4 inh.
or inducers.

DNA Polymerase Inhibitor. Ganciclovir 500 mg.
VIALS: 1, 5. Adults: Initially 5mg/kg
every 12 hrs. (at a constant rate of 1
hr.), every 12 hrs. by I.V. inf. for 14 - 21
days. Maint: 6mg/kg dly. by I.V. infus. 5
days/wk. or 5 mg/kg dly. for 7 days/wk.
Only in the tmt. of CMV retinit. in
immunocompromised pts., prevent. CMV
dis. in transplant pts. at risk for CMV dis.