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  • Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
    9 Drugs classified under this drug class


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    Descovy
    Gilead
    RX
    not in the basket chart
    Multiple ingredients
    Descovy

    Anti HIV, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Emtricitabine 200 mg, Tenofovir Alafenamide 10 mg, 25 mg.
    F.C. TABS.:30.  Dosage must be ajust. individ.
    Indicated in comb. with other antiretrovir. agents for the tmt. of adult. and adolesc. (aged 12 yrs. and older with bdy. wt. at least 35 kg) infect. with human immunodeficiency virus type 1 (HIV-1).
    C/I: Hypersens.

    Eviplera
    Janssen
    RX
    partial basket chart
    Multiple ingredients
    Eviplera

    Non-Nucleoside Reverse Transcriptase Inhibitors, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Emtricitavine 200 mg, Rilpivirine (as HCl) 25 mg, Tenofovir Disoproxil (as Fumarate) 245 mg.
    F.C. TABS: 30. Adults: 1 tab dly with
    meal. Under 18 yrs: Not recommend.
    Over 65 yrs: use with caution. Not
    recommend. in pts. with CLcr < 50 ml/
    min. See lit.
    Comb. of emtricitabine, tenofovir
    disoproxil fumarate and rilpivirine for use
    as a complete regimen for the tmt of HIV-1
    infect. in adult pts with no antiretrov. tmt
    hist. and with HIV-1 RNA less than or equal
    to 100,000 copies/mL at the start of ther.,
    and in certain virologic. suppress. (HIV-1
    RNA <50 copies/mL) adult pts on a stable
    antiretrov. regimen at start of ther. in order
    to replace their curr. antiretrov. tmt
    regimen.
    C/I: Hypersens. to act. subst. or to any
    excip., co-admin. with CYP3A induc. and
    gastric pH incr.: anticonvuls. –
    carbamazepine, oxcarbazapine,
    phenobarbital, phenytoin;
    antimycobacter. – rifampin, rifapentine;
    PPI – dexlansoprazole, esomeprazole,
    lansoprazole, omeprazole, antoprazole,
    rabeprazole; glucocorticoid systemic
    dexamethasone (more than a single
    dose); St. John’s wort (Hypericum
    perforatum).

    Lamicavir Teva
    Abic
    RX
    not in the basket chart
    Multiple ingredients
    Lamicavir Teva

    Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Abacavir 600 mg, Lamivudine 300 mg.
    The recommend. dose for Adult. and child. >12 weigh. at least 40 kg, is1 tab×1/d. See lit. Tmt.  of HIV  infec. in adult. and in child. over the age of 12 yrs.
    C/I: Hypersens.

    Lamivudine Zidovudine Teva
    Abic
    RX
    Multiple ingredients
    Lamivudine Zidovudine Teva

    Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Lamivudine 150 mg, Zidovudine 300 mg.
    TABS.: 60. Adult. /adolesc. ≥30 kg: 1 tab.
    ×2/d.
    Child. 21 kg - 30 kg: 1/2 tab. taken in
    the morn. and 1 whole tab. taken in the
    ev.
    Child. 14 kg- 21 kg: 1/2 tab.×2/d.
    Elderl.: decreas. in renal func. and
    alterat. of haemat. param. must be
    taken in consider.
    Renal impair.: Dosage adjust. is require.
    in pts. with a CrCl < 50 ml/min. Its
    recommend. separate preparat. of
    lamivudine, zidovudine should be
    admin. to these pts.
    Hep. impair.: Dosage adjust. may be
    necess. in pts.
    Its recommend.that separate preparat.
    of lamivudine, zidovudine should be
    admin. to these pts.
    Dosage adjust. in pts. with hemat.
    adverse react.: Dosage adjust. may be
    neces. if the Hb level falls below 9 g/dl
    or 5.59 mmol/l or the neutrophil count
    falls below 1.0 x 109/l. Separate prepar.
    of zidovudine, lamivudine should be used. May be admin. with or without
    food. See lit.
    Antiretroviral comb. ther. for the tmt. of
    HIV infec. adults&adolesc. over the age of
    12 yrs.
    C/I: Pts. with known hypersens. to
    lamivudine, zidovudine. Pts. with
    abnormal. low neutrophil counts (less
    than 0.75 x 109/l), or abnormal. low Hb
    levels (less than 7.5g/dl or 4.65 mmol/l).

    Retrovir Capsules
    GSK
    RX
    partial basket chart
    Retrovir Capsules

    Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Zidovudine 100 mg, 250 mg.
    CAPS.: 100 ×100 mg, 40 ×250 mg.
    Adults and adolecs.> 30 kg: 250-
    300 mg 2 x dly.
    Child 8-13 kg: 100 mg 2 x dly. 14- 21 kg: 100 mg morn. + 200 mg evening. 22-30 kg: 200 mg 2 x dly. 28—30 kg: 250 mg 2 x dly. in comb. with other anti-retrov. agent. 
    In combin. with anti-retroviral tmt
    for HIV infected adults and children. for
    use in HIV-+tive pregn. women (over 14
    wks of gestat.) for prevent. of maternal-foetal HIV transmiss. and for prim. prophyl.
    of HIV infect. in newborn infants.
    C/I: Hypersens., abnorm. low neutrophil
    counts (< 0.75 x 109/L) or abnorm. low
    HGB levels (less than 7.5 g/dL or 4.65
    mmol/L). Oral formul.- also: newborn
    infants with hyperbilirubin. requir. tmt
    other than phototherapy, or with
    increase. transaminase levels of over 5
    times the upper limit of normal.

    Retrovir IV for Infusion
    GSK
    RX
    partial basket chart
    Retrovir IV for Infusion

    Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Zidovudine 200 mg / 20 ml.
    I.V. SOL. FOR INFUS.: 200 mg/20 ml. See lit.
    Short term manag. of serious manifest. of HIV infect. in pts with AIDS unable to take
    Zidovudine oral formul. for use in HIV-
    +tive pregn. women (over 14 wks of
    gestat.) for prevent. of maternal-foetal HIV
    transmiss. and for prim. prophyl. of HIV
    infect. in newborn infants. Zidovudine I.V.
    should only be used when oral tmt is not
    possible (except during labour and
    delivery).
    C/I: Hypersens., abnorm. low neutrophil
    counts (< 0.75 x 109/L) or abnorm. low
    HGB levels (less than 7.5 g/dL or 4.65
    mmol/L). Oral formul.- also: newborn
    infants with hyperbilirubin. requir. tmt
    other than phototherapy, or with
    increase. transaminase levels of over 5
    times the upper limit of normal.

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