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  • Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
    10 Drugs classified under this drug class


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    Descovy
    Gilead
    RX
    not in the basket chart
    Multiple ingredients
    Descovy

    Anti HIV, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Emtricitabine 200 mg, Tenofovir Alafenamide 10 mg, 25 mg.
    F.C. TABS.:30.  Dosage must be ajust. individ.
    Indicated in comb. with other antiretrovir. agents for the tmt. of adult. and adolesc. (aged 12 yrs. and older with bdy. wt. at least 35 kg) infect. with human immunodeficiency virus type 1 (HIV-1).
    C/I: Hypersens.

    Eviplera
    Janssen
    RX
    partial basket chart
    Multiple ingredients
    Eviplera

    Non-Nucleoside Reverse Transcriptase Inhibitors, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Emtricitavine 200 mg, Rilpivirine (as HCl) 25 mg, Tenofovir Disoproxil (as Fumarate) 245 mg.
    F.C. TABS: 30. Adults: 1 tab dly with
    meal. Under 18 yrs: Not recommend.
    Over 65 yrs: use with caution. Not
    recommend. in pts. with CLcr < 50 ml/
    min. See lit.
    Comb. of emtricitabine, tenofovir
    disoproxil fumarate and rilpivirine for use
    as a complete regimen for the tmt of HIV-1
    infect. in adult pts with no antiretrov. tmt
    hist. and with HIV-1 RNA less than or equal
    to 100,000 copies/mL at the start of ther.,
    and in certain virologic. suppress. (HIV-1
    RNA <50 copies/mL) adult pts on a stable
    antiretrov. regimen at start of ther. in order
    to replace their curr. antiretrov. tmt
    regimen.
    C/I: Hypersens. to act. subst. or to any
    excip., co-admin. with CYP3A induc. and
    gastric pH incr.: anticonvuls. –
    carbamazepine, oxcarbazapine,
    phenobarbital, phenytoin;
    antimycobacter. – rifampin, rifapentine;
    PPI – dexlansoprazole, esomeprazole,
    lansoprazole, omeprazole, antoprazole,
    rabeprazole; glucocorticoid systemic
    dexamethasone (more than a single
    dose); St. John’s wort (Hypericum
    perforatum).

    Kivexa
    GSK
    RX
    partial basket chart
    Multiple ingredients
    Kivexa

    Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Abacavir (as sulfate) 600 mg, Lamivudine 300 mg.
    F.C. TABS: 30. Adults and adolesc. from
    12 yrs. 1 x dly. See lit.
    Fixed-dose comb. ther. for the tmt. of HIV
    inf. in adults and adolescents from 12
    years of age.
    C/I: Hypersens. to product, espec.
    abacavir hypersensitivity reactions;
    severe hepatic impairment.

    Lamicavir Teva
    Abic
    RX
    not in the basket chart
    Multiple ingredients
    Lamicavir Teva

    Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Abacavir 600 mg, Lamivudine 300 mg.
    The recommend. dose for Adult. and child. >12 weigh. at least 40 kg, is1 tab×1/d. See lit. Tmt.  of HIV  infec. in adult. and in child. over the age of 12 yrs.
    C/I: Hypersens.

    Lamivudine Teva 100 mg
    Abic
    RX
    partial basket chart
    Lamivudine Teva 100 mg

    Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Lamivudine 100 mg.
    TAB: 100 mg: x 30 tablets.
    Adults 100 mg x 1 dly. Safety and
    effectiveness of beyond 1 yr have not
    been established and the optimum
    duration of treatment is not known.
    Pediatric Patients (2 to 17 years of age)
    3 mg/kg once daily up to a maximum
    daily dose of 100 mg. Safety and
    effectiveness of treatment beyond 1 year
    have not been established and the
    optimum duration of treatment is not
    known.
    Dose Adjustment: It is recommended
    that the doses be adjusted in
    accordance with renal function.
    Treatment of chronic hepatitis B
    associated with the evidence of hepatitis B
    viral (HBV) replication and active liver
    inflammation in adults and also in
    children and adolescents aged 2 to 17
    years old.
    C/I: Known hypersens. to lamivudine or
    to any other ingredient of the product.

    Lamivudine Zidovudine Teva
    Abic
    RX
    Multiple ingredients
    Lamivudine Zidovudine Teva

    Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Lamivudine 150 mg, Zidovudine 300 mg.
    TABS.: 60. Adult. /adolesc. ≥30 kg: 1 tab.
    ×2/d.
    Child. 21 kg - 30 kg: 1/2 tab. taken in
    the morn. and 1 whole tab. taken in the
    ev.
    Child. 14 kg- 21 kg: 1/2 tab.×2/d.
    Elderl.: decreas. in renal func. and
    alterat. of haemat. param. must be
    taken in consider.
    Renal impair.: Dosage adjust. is require.
    in pts. with a CrCl < 50 ml/min. Its
    recommend. separate preparat. of
    lamivudine, zidovudine should be
    admin. to these pts.
    Hep. impair.: Dosage adjust. may be
    necess. in pts.
    Its recommend.that separate preparat.
    of lamivudine, zidovudine should be
    admin. to these pts.
    Dosage adjust. in pts. with hemat.
    adverse react.: Dosage adjust. may be
    neces. if the Hb level falls below 9 g/dl
    or 5.59 mmol/l or the neutrophil count
    falls below 1.0 x 109/l. Separate prepar.
    of zidovudine, lamivudine should be used. May be admin. with or without
    food. See lit.
    Antiretroviral comb. ther. for the tmt. of
    HIV infec. adults&adolesc. over the age of
    12 yrs.
    C/I: Pts. with known hypersens. to
    lamivudine, zidovudine. Pts. with
    abnormal. low neutrophil counts (less
    than 0.75 x 109/l), or abnormal. low Hb
    levels (less than 7.5g/dl or 4.65 mmol/l).

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