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  • Non-Nucleoside Reverse Transcriptase Inhibitors
    6 Drugs classified under this drug class


    All the Drug Class Drugs

    Edurant
    Janssen
    RX
    partial basket chart
    Edurant

    Non-Nucleoside Reverse Transcriptase Inhibitors. Rilpivirine 25 mg.
    F.C. TABS. 30. 1 tab. once dly. taken
    orally with a meal.
    Tmt. of HIV-1 infec. in tmt. naïve adult pts.
    in comb. with other antiretroviral.
    C/I: Concom. use with: anticonvulsants:
    carbamazepine, oxcarbazepine,
    phenobarbital, phenytoin.
    Antimycobac.: rifabutin, rifampin,
    rifapentine.
    PPI: esomeprazole, lansoprazole,
    omeprazole, pantoprazole, rabeprazole.
    Syst. use of glucocort. : dexamethasone
    (more than a sing. dose)
    St. John’s wort (Hypericum perforatum).

    Eviplera
    Janssen
    RX
    partial basket chart
    Multiple ingredients
    Eviplera

    Non-Nucleoside Reverse Transcriptase Inhibitors, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors. Emtricitavine 200 mg, Rilpivirine (as HCl) 25 mg, Tenofovir Disoproxil (as Fumarate) 245 mg.
    F.C. TABS: 30. Adults: 1 tab dly with
    meal. Under 18 yrs: Not recommend.
    Over 65 yrs: use with caution. Not
    recommend. in pts. with CLcr < 50 ml/
    min. See lit.
    Comb. of emtricitabine, tenofovir
    disoproxil fumarate and rilpivirine for use
    as a complete regimen for the tmt of HIV-1
    infect. in adult pts with no antiretrov. tmt
    hist. and with HIV-1 RNA less than or equal
    to 100,000 copies/mL at the start of ther.,
    and in certain virologic. suppress. (HIV-1
    RNA <50 copies/mL) adult pts on a stable
    antiretrov. regimen at start of ther. in order
    to replace their curr. antiretrov. tmt
    regimen.
    C/I: Hypersens. to act. subst. or to any
    excip., co-admin. with CYP3A induc. and
    gastric pH incr.: anticonvuls. –
    carbamazepine, oxcarbazapine,
    phenobarbital, phenytoin;
    antimycobacter. – rifampin, rifapentine;
    PPI – dexlansoprazole, esomeprazole,
    lansoprazole, omeprazole, antoprazole,
    rabeprazole; glucocorticoid systemic
    dexamethasone (more than a single
    dose); St. John’s wort (Hypericum
    perforatum).

    Intelence
    Janssen
    RX
    partial basket chart
    Intelence

    Non-Nucleoside Reverse Transcriptase Inhibitors. Etravirine 100 mg, 200 mg.
    Etravirine 100 mg: TABS: 120. Adults over 18 yrs: 2 tabs 2 x dly with food.
    In comb. with other antiretrovir. for tmt
    HIV-1 infect. in antiretrovir. tmt-experenced
    adults incl. those with non-nucleoside reverse transcriptase inhibit. (NNRTI) resist. See lit.
    Etravirine 200 mg: TABS: 60. Adults over 18 yrs: 200 mg 2 x dly with food.
    In comb. with other antiretrovir. for tmt
    HIV-1 infect. in antiretrovir. tmt
    experenced adults incl. those with NNRTI
    resist. Not recommend. in comb. with N(t)
    RTIs only in pts. who have experienc.
    virology. fail. On an NNRTI and N(t)RTIcontai. regimen
    C/I: Hypersens.

    Stocrin 600 mg
    MSD
    RX
    partial basket chart
    Stocrin 600 mg

    Non-Nucleoside Reverse Transcriptase Inhibitors. Efavirenz 600 mg.
    F.C TABS: 30 x 600 mg. 600 mg 1 x dly. Children 3 yrs. and older (10-40 kg): See lit.
    In combinat. with other antiretrovir.
    agents for the tmt. of HIV-1 infects. 
    C/I: Hypersens.

    Viramune 200 mg Tablets
    Boehringer Ingelheim
    RX
    partial basket chart
    Viramune 200 mg Tablets

    Non-Nucleoside Reverse Transcriptase Inhibitors. Nevirapine (as anhydrous) 200 mg.
    TABS. (anhydrous): 60 x 200 mg. 1
    tab×1/d for 14 days, follow. by 1
    tab×2/d. in comb. with other
    antiretrovir. ther.
    For use in comb. with other antiretrov.
    agents for the tmt. of HIV-1 infec. in
    adults, adolescents, and child. of any age.
    Most of the experience with Nevirapine is
    in comb. with nucleoside reverse
    transcriptase inhibitors (NRTIs). The
    choice of a subsequent ther. after Nevirapine should be based on clinical
    experience and resistance testing.
    C/I: Hypersens., Readministr. to pts. who
    required permanent discount. for severe
    rash, rash accompanied by constitutional
    sympts., hypersens. react., or clinical
    hepatitis due to nevirapine, severe
    hepatic impair. (Child-Pugh C) or pretreatment ASAT or ALAT > 5 ULN until
    baseline ASAT/ALAT are stabilised < 5
    ULN. Readministr. to pts who previous. had
    ASAT or ALAT > 5 ULN during nevirapine ther. and had recur. of liver function abnormalit. upon readministr. of nevirapine, Coadministr. with herbal preparations containing St. John’s wort (Hypericum perforatum) due to risk of decreased plasma concentr. and reduced clinical effects of nevirapine.

    Viramune 50 mg/5 ml Oral Suspension
    Boehringer Ingelheim
    RX
    partial basket chart
    Viramune 50 mg/5 ml Oral Suspension

    Non-Nucleoside Reverse Transcriptase Inhibitors. Nevirapine (as hemihydrate) 50 mg/5 ml.
    SUSP.: 240 ml x 10 mg/ml.
    Child.: 0 - 8 yrs.: 4 mg/kg×1/d. for 14
    days, follow. by 7 mg/kg×2/d; 8 yrs.
    and over: 4 mg/kg×1/d for 2 wks.,
    follow. by 4 mg/kg×2/d. Alternat.
    dosing, child.:– 150 mg/m2×1/d for 14
    days, follow. by 150 mg/m2×2/d. max.
    dly. dose: 400 mg. See lit.
    For use in comb. with other antiretrov.
    agents for the tmt. of HIV-1 infec. in
    adults, adolescents, and child. of any age.
    Most of the experience with Nevirapine is
    in comb. with nucleoside reverse
    transcriptase inhibitors (NRTIs). The
    choice of a subsequent ther. after Nevirapine should be based on clinical
    experience and resistance testing.
    C/I: Hypersens., Readministr. to pts. who
    required permanent discount. for severe
    rash, rash accompanied by constitutional
    sympts., hypersens. react., or clinical
    hepatitis due to nevirapine, severe
    hepatic impair. (Child-Pugh C) or pretreatment ASAT or ALAT > 5 ULN until
    baseline ASAT/ALAT are stabilised < 5
    ULN. Readministr. to pts who previous. had
    ASAT or ALAT > 5 ULN during nevirapine ther. and had recur. of liver function abnormalit. upon readministr. of nevirapine, Coadministr. with herbal preparations containing St. John’s wort (Hypericum perforatum) due to risk of decreased plasma concentr. and reduced clinical effects of nevirapine.

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