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  • Fungal Infections
    19 Drugs classified under this therapeutic system


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    AmBisome
    Gilead
    RX
    partial basket chart
    AmBisome

    Antifungal. Amphotericin B 50 mg/vial.
    VIALS: 10. 1 mg/kg bdy. wt. dly. incr.
    step-wise as reqd. I.V. infus. over 30-60
    mins. See lit.
    Severe system. and/or deep mycoses,
    where toxicity (partic. nephrotox.)
    precludes use of convent. ther., syst. fung.
    infects. in immunocomp. pts., prim. ther.
    visceral leishman. in immunocompetent
    pts., immuno-compromised pts. e.g. HIV pos.
    C/I: Hypersens.

    Cancidas 50 mg
    MSD
    RX
    partial basket chart
    Cancidas 50 mg

    Antifungal. Caspofungin (as acetate) 50 mg/vial.
    VIALS: (lyophilized pwdr. for inject.): 1 x
    50 mg, 70 mg. Single 70 mg load. dose
    on day 1, foll. by 50 mg dly by slow I.V.
    infus. over approx. 1 hr.
    Candidemia and other candida infects:
    intra-abdom. abscesses, peritonit.,
    pleural space infects. Esophag. candidias.
    Invas. aspergillosis in pts. who are
    refractory to or intol. of other therap.
    C/I: Hypersens.

    Cancidas 70 mg
    MSD
    RX
    partial basket chart
    Cancidas 70 mg

    Antifungal. Caspofungin (as acetate) 70 mg/vial.
    VIALS: (lyophilized pwdr. for inject.): 1 x
    50 mg, 70 mg. Single 70 mg load. dose
    on day 1, foll. by 50 mg dly by slow I.V.
    infus. over approx. 1 hr.
    Candidemia and other candida infects:
    intra-abdom. abscesses, peritonit.,
    pleural space infects. Esophag. candidias.
    Invas. aspergillosis in pts. who are
    refractory to or intol. of other therap.
    C/I: Hypersens.

    Daktarin Oral Gel
    Janssen
    OTC
    full basket chart
    Daktarin Oral Gel

    Antifungal, Antiinfectives. Miconazole 20 mg/g.
    ORAL GEL: 40 g.
    Oropharyngeal candidosis: Infants
    (6-24 mnths): 1.25 mL of gel x 4/d after
    meals. Adults, children (>2 yrs old): 2.5
    mLof gel x 4/d after meals.
    GI tract candidosis: Infants (≥ 6
    mnths), Children, Adults: 20 mg/kg/day x 4 divided doses. The daily dose
    should not exceed 250 mg x 4/d. See
    lit.
    Oral mycosis (thrush), fungal infect. of the
    upper GI tract. Prevent. of oral thrush in
    pts receiv. long-termtmt with antibiotics,
    steroids, cytotoxic and radiation ther.
    C/I: Hypersens. to act. ingred.,exipient,
    or other imidazole derive.; infants under
    6 mnths. or in those whose swall. reflex
    is not yet suffic. developed; pts.with
    liver dysfunct.; Coadmin.of the foll.
    drugs that are subject to metab. by
    CYP3A4: Substr. known to prolong the
    QT-interval e.g., astemizole, bepridil,
    cisapride, dofetilide, halofantrine,
    mizolastine, pimozide, quinidine,
    sertindole and terfenadine; Ergot
    alkaloids;HMG-CoA reduct.inh. such as
    simvastatin and lovastatin; Triazolam,
    oral midazolam.

    Diflucan
    Pfizer
    RX
    partial basket chart
    Diflucan

    Antifungal. Fluconazole 50 mg / 5 ml.
    PWDR. FOR SUSP: 35 ml x 50 mg/5 ml.
    System. candidias: 400 mg on day 1
    foll. by 200 mg dly; may be incr. to 400
    mg dly. Cryptococc., incl. cryptococc.
    meningit: 400 mg on day 1 foll. by 200-
    400 mg 1 x dly for 6-8 wks. Prevent.
    relapse cryptococc. meningit. in pt.
    with AIDS aft. receive full course ther:
    200 mg dly Mucos. candidias;
    oropharyng. candidias: 50 mg 1 x dly
    for 7-14 days. Atroph. oral candidias.
    assoc. with dentures: 50 mg 1 x dly for
    14 days with local antisept. for
    dentures. Esophagit: 50-100 mg dly for
    14-30 days. Non-invasive
    bronchopulm. infects, candiduria and
    other candidias. infects. mucosa
    (except vag. candid.): 50-100 mg dly
    for 14-30 days. Vag. candid: 150 mg dly
    as single oral dose.

    Eraxis
    Pfizer
    RX
    partial basket chart
    Eraxis

    Antifungal. Anidulafungin 100 mg.
    VIAL (pwdr. for inject): 1 x 100 mg.
    A single 200 mg load. dose should be
    admin. on Day 1, follow. by 100 mg
    dly. thereafter. Durat. of tmt. should be
    based on the pt’s. clinic. response. In
    general, antifung. ther. should contin.
    for at least 14 d after the last posit.
    culture.
    Durat. of tmt.: There are insuffic. data
    to support the 100 mg dose for longer
    than 35 d. of tmt. See lit.
    Tmt. of invasive candidiasis in adult pts.
    C/I: Hypersens.
    Hypersens. to other meds of the
    echinocandin class.


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