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  • Fungal Infections
    24 Drugs classified under this therapeutic system


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    AmBisome
    Gilead
    RX
    partial basket chart
    AmBisome

    Antifungal. Amphotericin B 50 mg/vial.
    VIALS: 10. 1 mg/kg bdy. wt. dly. incr.
    step-wise as reqd. I.V. infus. over 30-60
    mins. See lit.
    Severe system. and/or deep mycoses,
    where toxicity (partic. nephrotox.)
    precludes use of convent. ther., syst. fung.
    infects. in immunocomp. pts., prim. ther.
    visceral leishman. in immunocompetent
    pts., immuno-compromised pts. e.g. HIV pos.
    C/I: Hypersens.

    Cancidas 50 mg
    MSD
    RX
    partial basket chart
    Cancidas 50 mg

    Antifungal. Caspofungin (as acetate) 50 mg/vial.
    VIALS: (lyophilized pwdr. for inject.): 1 x
    50 mg, 70 mg. Single 70 mg load. dose
    on day 1, foll. by 50 mg dly by slow I.V.
    infus. over approx. 1 hr.
    Candidemia and other candida infects:
    intra-abdom. abscesses, peritonit.,
    pleural space infects. Esophag. candidias.
    Invas. aspergillosis in pts. who are
    refractory to or intol. of other therap.
    C/I: Hypersens.

    Cancidas 70 mg
    MSD
    RX
    partial basket chart
    Cancidas 70 mg

    Antifungal. Caspofungin (as acetate) 70 mg/vial.
    VIALS: (lyophilized pwdr. for inject.): 1 x
    50 mg, 70 mg. Single 70 mg load. dose
    on day 1, foll. by 50 mg dly by slow I.V.
    infus. over approx. 1 hr.
    Candidemia and other candida infects:
    intra-abdom. abscesses, peritonit.,
    pleural space infects. Esophag. candidias.
    Invas. aspergillosis in pts. who are
    refractory to or intol. of other therap.
    C/I: Hypersens.

    Cresemba 100 mg Capsules
    Pfizer
    RX
    partial basket chart
    Cresemba 100 mg Capsules

    Antimycotic, Triazole Derivatives. Isavuconazole 100 mg.
    CAPS.: 14. Loading dose is 2 caps (200mg)×3/d every 8 hrs. for the first 48 hrs. (6 admin. in total).
    Mainten. dose: 2 caps. (200mg)×1/d, start. 12-24 hrs. after the last load. dose. Durat. of ther. should be determin. by the clinic. response.
    For long-term tmt. beyond 6 mnths., the benefit-risk balance should be careful. consid.
    Tmt. of invas. aspergillosis; mucormycosis in pt. for whom amphotericin B is inapprop.  Consider. should be given to offic. guidance on the approp. use of antifung. agents.
    C/I: Hypersens. Co-admin. with ketoconazole. Co-admin. with high-dose ritonavir (>200 mg every 12 hrs). Co-admin. with strong CYP3A4/5 induc. such as rifampicin, rifabutin, carbamazepine, long-act. barbiturates (e.g. phenobarbital), phenytoin and St. John’s wort or with moder. CYP3A4/5 induc. such as efavirenz, nafcillin & etravirine. Pts. with famil. short QT syndr.

    Cresemba 200 mg IV
    Pfizer
    RX
    partial basket chart
    Cresemba 200 mg IV

    Antimycotic, Triazole Derivatives. Isavuconazole 200 mg.
    VIAL (pwdr. for concentrat. for sol. for infus.): 1×10ml. Load. dose: The recomm. load. dose is 1 vial after reconstit. & dilute. (equiv. to 200 mg of isavuconazole) every 8 hrs. for the first 48 hrs. (6 admin. in total).
    Mainten. dose: The recom. mainten. dose is one vial after reconstit. and dilute. (equiv. to 200 mg of isavuconazole) once dly., starting 12- 24 hrs. after the last load. dose.
    Durat. of therapy should be determ. by the clinical response.
    For long-term tmt. beyond 6 mnths., the benefit-risk balance should be carefully considered.
    Switch to oral isavuconazole: This drug  is also available as hard caps. contain. 100 mg isavuconazole, equiv. to 186 mg isavuconazonium sulfate. See lit.
    Indic. in adult. for the tmt. of: Invasive aspergillosis, mucormycosis in pts. for whom amphotericin B is inappropr.
    Consideration should be given to official guidance on the appropr. use of antifung. agents.
    C/I: Hypersens. Co-admin. with ketoconazole. Co-admin. with high-dose ritonavir (>200 mg every 12 hrs.).
    Co-admin. with strong CYP3A4/5 induc. such as rifampicin, rifabutin, carbamazepine, long-act. barbiturates (e.g. phenobarbital), phenytoin and St. John’s wort or with moder. CYP3A4/5 induc. (e.g. efavirenz, nafcillin, etravirine). Pts. with familial short QT syndr.

    Daktarin Oral Gel
    Janssen
    OTC
    full basket chart
    Daktarin Oral Gel

    Antifungal, Antiinfectives. Miconazole 20 mg/g.
    ORAL GEL: 40 g.
    Oropharyngeal candidosis: Infants
    (6-24 mnths): 1.25 mL of gel x 4/d after
    meals. Adults, children (>2 yrs old): 2.5
    mLof gel x 4/d after meals.
    GI tract candidosis: Infants (≥ 6
    mnths), Children, Adults: 20 mg/kg/day x 4 divided doses. The daily dose
    should not exceed 250 mg x 4/d. See
    lit.
    Oral mycosis (thrush), fungal infect. of the
    upper GI tract. Prevent. of oral thrush in
    pts receiv. long-termtmt with antibiotics,
    steroids, cytotoxic and radiation ther.
    C/I: Hypersens. to act. ingred.,exipient,
    or other imidazole derive.; infants under
    6 mnths. or in those whose swall. reflex
    is not yet suffic. developed; pts.with
    liver dysfunct.; Coadmin.of the foll.
    drugs that are subject to metab. by
    CYP3A4: Substr. known to prolong the
    QT-interval e.g., astemizole, bepridil,
    cisapride, dofetilide, halofantrine,
    mizolastine, pimozide, quinidine,
    sertindole and terfenadine; Ergot
    alkaloids;HMG-CoA reduct.inh. such as
    simvastatin and lovastatin; Triazolam,
    oral midazolam.


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