All the Drug Class Drugs
Antimycotic, Triazole Derivatives. Isavuconazole 100 mg. CAPS.: 14. Loading dose is 2 caps (200mg)×3/d every 8 hrs. for the first 48 hrs. (6 admin. in total).
Mainten. dose: 2 caps. (200mg)×1/d, start. 12-24 hrs. after the last load. dose. Durat. of ther. should be determin. by the clinic. response.
For long-term tmt. beyond 6 mnths., the benefit-risk balance should be careful. consid.
Tmt. of invas. aspergillosis; mucormycosis in pt. for whom amphotericin B is inapprop. Consider. should be given to offic. guidance on the approp. use of antifung. agents.
C/I: Hypersens. Co-admin. with ketoconazole. Co-admin. with high-dose ritonavir (>200 mg every 12 hrs). Co-admin. with strong CYP3A4/5 induc. such as rifampicin, rifabutin, carbamazepine, long-act. barbiturates (e.g. phenobarbital), phenytoin and St. John’s wort or with moder. CYP3A4/5 induc. such as efavirenz, nafcillin & etravirine. Pts. with famil. short QT syndr.
Antimycotic, Triazole Derivatives. Isavuconazole 200 mg. VIAL (pwdr. for concentrat. for sol. for infus.): 1×10ml. Load. dose: The recomm. load. dose is 1 vial after reconstit. & dilute. (equiv. to 200 mg of isavuconazole) every 8 hrs. for the first 48 hrs. (6 admin. in total).
Mainten. dose: The recom. mainten. dose is one vial after reconstit. and dilute. (equiv. to 200 mg of isavuconazole) once dly., starting 12- 24 hrs. after the last load. dose.
Durat. of therapy should be determ. by the clinical response.
For long-term tmt. beyond 6 mnths., the benefit-risk balance should be carefully considered.
Switch to oral isavuconazole: This drug is also available as hard caps. contain. 100 mg isavuconazole, equiv. to 186 mg isavuconazonium sulfate. See lit.
Indic. in adult. for the tmt. of: Invasive aspergillosis, mucormycosis in pts. for whom amphotericin B is inappropr.
Consideration should be given to official guidance on the appropr. use of antifung. agents.
C/I: Hypersens. Co-admin. with ketoconazole. Co-admin. with high-dose ritonavir (>200 mg every 12 hrs.).
Co-admin. with strong CYP3A4/5 induc. such as rifampicin, rifabutin, carbamazepine, long-act. barbiturates (e.g. phenobarbital), phenytoin and St. John’s wort or with moder. CYP3A4/5 induc. (e.g. efavirenz, nafcillin, etravirine). Pts. with familial short QT syndr.
