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  • Antimycotic
    2 Drugs classified under this drug class


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    Cresemba 100 mg Capsules
    Pfizer
    RX
    partial basket chart
    Cresemba 100 mg Capsules

    Antimycotic, Triazole Derivatives. Isavuconazole 100 mg.
    CAPS.: 14. Loading dose is 2 caps (200mg)×3/d every 8 hrs. for the first 48 hrs. (6 admin. in total).
    Mainten. dose: 2 caps. (200mg)×1/d, start. 12-24 hrs. after the last load. dose. Durat. of ther. should be determin. by the clinic. response.
    For long-term tmt. beyond 6 mnths., the benefit-risk balance should be careful. consid.
    Tmt. of invas. aspergillosis; mucormycosis in pt. for whom amphotericin B is inapprop.  Consider. should be given to offic. guidance on the approp. use of antifung. agents.
    C/I: Hypersens. Co-admin. with ketoconazole. Co-admin. with high-dose ritonavir (>200 mg every 12 hrs). Co-admin. with strong CYP3A4/5 induc. such as rifampicin, rifabutin, carbamazepine, long-act. barbiturates (e.g. phenobarbital), phenytoin and St. John’s wort or with moder. CYP3A4/5 induc. such as efavirenz, nafcillin & etravirine. Pts. with famil. short QT syndr.

    Cresemba 200 mg IV
    Pfizer
    RX
    partial basket chart
    Cresemba 200 mg IV

    Antimycotic, Triazole Derivatives. Isavuconazole 200 mg.
    VIAL (pwdr. for concentrat. for sol. for infus.): 1×10ml. Load. dose: The recomm. load. dose is 1 vial after reconstit. & dilute. (equiv. to 200 mg of isavuconazole) every 8 hrs. for the first 48 hrs. (6 admin. in total).
    Mainten. dose: The recom. mainten. dose is one vial after reconstit. and dilute. (equiv. to 200 mg of isavuconazole) once dly., starting 12- 24 hrs. after the last load. dose.
    Durat. of therapy should be determ. by the clinical response.
    For long-term tmt. beyond 6 mnths., the benefit-risk balance should be carefully considered.
    Switch to oral isavuconazole: This drug  is also available as hard caps. contain. 100 mg isavuconazole, equiv. to 186 mg isavuconazonium sulfate. See lit.
    Indic. in adult. for the tmt. of: Invasive aspergillosis, mucormycosis in pts. for whom amphotericin B is inappropr.
    Consideration should be given to official guidance on the appropr. use of antifung. agents.
    C/I: Hypersens. Co-admin. with ketoconazole. Co-admin. with high-dose ritonavir (>200 mg every 12 hrs.).
    Co-admin. with strong CYP3A4/5 induc. such as rifampicin, rifabutin, carbamazepine, long-act. barbiturates (e.g. phenobarbital), phenytoin and St. John’s wort or with moder. CYP3A4/5 induc. (e.g. efavirenz, nafcillin, etravirine). Pts. with familial short QT syndr.

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