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  • Antituberculosis and Antileprotic Preparations
    3 Drugs classified under this therapeutic system


    All the Therapeutic System Drugs

    GRANUPAS
    Trumed
    RX
    partial basket chart
    GRANUPAS

    Antitubercular Agent. 4-Aminosalicylic Acid 4 g.
    SACHETS (gastro-resist. granul.): 30. Adult.: 4 g (one sachet) ×3/d. The recomm. schedule is 4 g every 8 hrs., can be taken with food. Max. dly. dose is 12 g. Usual durat. of tmt. is 24 mnths.
    Ped. popul.: The optimal dose regim. in child. is uncertain. Limited pharmacokin. data suggest no substant. difference betwn. adult. & child.
    For infants, child. & adolesc. the dosage will be adapted to the pt’s. weight at 150 mg/kg/d, divided in two intakes. A dosing spoon is provid. to measure small doses below 4g for young child. See lit.
    Indicated for use as part of an appropriate combin. regimen for multi-drug resist. tuberculos. in adult. & ped. pts. from 28 d. of age and older when an effective tmt. regimen cannot otherwise be compos. for reasons of resist. or tolerab.
    Consid. should be given to official guidance on the appropriate use of antibacter. agents.
    C/I: Hypersens. Severe ren. dis. Pts. with severe renal impair. should not receive GRANUPAS. Patients with severe renal dis. will accumulate the inactive acetyl metabolite of 4-aminosalicylic acid.

    Mycobutin
    Pfizer
    RX
    partial basket chart
    Mycobutin

    Antibiotics. Rifabutin 150 mg.
    HARD CAPS.: 30.
    Gener. Admin. as a single, dly., oral
    dose at any time independ. of meals.
    Adult.: As monother.- Prophyl. of MAC
    infec. in immune-depres. Pts.: 300 mg
    (2 caps.).
    In comb. regimens: Non-tuberc.
    mycobact. dis.: 450-600 mg (3 to 4
    caps.) for up to 6 mnths. after negat.
    cultures are obtained.
    MAC tmt.: in comb with clarithromycin,
    the dosage of Rifabutin should be
    reduced to 300 mg after the 1st month
    of tmt.
    Pulmon. tuberculosis: 150 mg dly. (1
    cap.), for 6-9 mnths., or for at least 6
    mnths. after negat.cultures are
    obtained. Should be incr. to 300-450
    mg/d in pts. prev. treated with
    antituberculous drugs.
    Chron. tuberculosis where there is firm
    evidence of acid fast bacteria resist. to
    Rifampicin or to two other alternative
    drugs.
    Tmt. of infec. caused by MAC or other
    atyp. mycobact. where there is evidence
    of resist. bacteria as above.
    Tmt. of infec. caused by MAC or other
    atypical mycobact. in AIDS pts. in all
    cases not subject to the above
    restrictions.
    Preven. of MAC infect. in AIDS pts. whose
    CD4 counts lower or eqval to 200mm3.
    C/I: Hypersens. /hist. of hypersens. to
    the active substance, other rifamycins
    (e.g. rifampicin). Preg. & lact. Child.

    Zinforo
    Pfizer
    RX
    not in the basket chart
    Zinforo

    Other Cephalosporins & Penems. Ceftaroline Fosamil 600 mg.
    VIAL.: 10. The recommend. tmt. durat. for cSSTI is 5 to 14 days and the recommend. durat. of tmt. for CAP is 5 to 7 days.
    Adult. with normal ren. func., (CrCL) > 50 mL/min: cSSTI, CAP-600 mg, infus. 60 min. every 12 hrs.
    Ped. pts. with norm. ren. func., (CrCL) > 50 mL/min. (Calculat. using the Schwartz form. (in mL/min/1.73 m²) for paed. pts.).
    cSSTI: Adolesc. aged 12 to<18 yrs. with bdy. wt.≥33 kg-600mg, infus. 60 min. every 12 hrs.
    Adolesc. 12 yrs. to<18 yrs. bdy. wt.<33 kg and child.≥2 yrs. to<12 yrs Calculat. using the Schwartz form. (in mL/min/1.73 m²) for paed. pts.) -12 mg/kg to a max. of 400 mg, infus. 60 min. every 8 hrs.
    CAP: Infant.≥2 mnths. to<2 yrs.- 8 mg/kg, infus. 60 min every 8 hrs.
    Dosage in adults & adolesc. with impair. ren. func., (CrCL)≤ 50 mL/min: See lit.
    Indicated in adult. & child. from age of 2 mnths. for the tmt. of the following infec.:
    Complic. skin&soft tissue infec. (cSSTI).
    Community-acquir. pneumon. (CAP) Consider. should be given to official guidance on the appropriate use of antibact. agents.
    C/I: Hypersens. to the act. subst. or it’s excip. Hypersens. to the cephalosp. class of antib. Anaphyl. react. to any other type of beta-lactam antib. (e.g. penicillins or carbapenems.).


    Other therapeutic systems under Infections

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