All the Therapeutic System Drugs
Antitubercular Agent. 4-Aminosalicylic Acid 4 g. SACHETS (gastro-resist. granul.): 30. Adult.: 4 g (one sachet) ×3/d. The recomm. schedule is 4 g every 8 hrs., can be taken with food. Max. dly. dose is 12 g. Usual durat. of tmt. is 24 mnths.
Ped. popul.: The optimal dose regim. in child. is uncertain. Limited pharmacokin. data suggest no substant. difference betwn. adult. & child.
For infants, child. & adolesc. the dosage will be adapted to the pt’s. weight at 150 mg/kg/d, divided in two intakes. A dosing spoon is provid. to measure small doses below 4g for young child. See lit.
Indicated for use as part of an appropriate combin. regimen for multi-drug resist. tuberculos. in adult. & ped. pts. from 28 d. of age and older when an effective tmt. regimen cannot otherwise be compos. for reasons of resist. or tolerab.
Consid. should be given to official guidance on the appropriate use of antibacter. agents.
C/I: Hypersens. Severe ren. dis. Pts. with severe renal impair. should not receive GRANUPAS. Patients with severe renal dis. will accumulate the inactive acetyl metabolite of 4-aminosalicylic acid.
Antibiotics. Rifabutin 150 mg. HARD CAPS.: 30.
Gener. Admin. as a single, dly., oral
dose at any time independ. of meals.
Adult.: As monother.- Prophyl. of MAC
infect. in immune-depres. pts.: 300 mg
(2 caps.).
In comb. regimens: Non-tuberc.
mycobact. dis.: 450-600 mg (3 to 4
caps.) for up to 6 mnths. after negat.
cultures are obtained.
MAC tmt.: in comb. with clarithromycin,
the dosage of Rifabutin should be
reduced to 300 mg after the 1st month
of tmt.
Pulmon. tuberc.: 150 mg dly. (1
cap.), for 6-9 mnths., or for at least 6
mnths. after negat. cultures are
obtained. Should be incr. to 300-450
mg/d in pts. prev. treated with
antituberculous drugs.
Chron. tuberculosis where there is firm
evid. of acid fast bacteria resist. to
Rifampicin or to two other alternat.
drugs.
Tmt. of infect. caused by MAC or other
atyp. mycobact. where there is evid.
of resist. bacteria as above.
Tmt. of infect. caused by MAC or other
atypical mycobact. in AIDS pts. in all
cases not subject to the above
restrictions.
Prevent. of MAC infect. in AIDS pts. whose
CD4 counts are lower or equal to 200mm3.
C/I: hypersens. incl. to other rifamycins
(e.g. rifampicin). Pregn. & lact. Childr.
Concom. use with rilpivirine contain. prolonged-rel. suspens. for inject.
Antitubercular Agent. Bedaquiline 100 mg. Tabs: 188X 100 mg
To be admin. by a phys. experienced in multi-drug resist. Mycobacterium tuberculosis
• Weeks 1-2: 400 mg (4 tablets of 100 mg) once daily
• Weeks 3-24: 200 mg (2 tablets of 100 mg) three times per week (with at least 48 hours between doses). Durat. of tmt. is 24 weeks. See prescr. details.
As part of combin. regimen for pulmonary multidrug-resistant tubercul. (MDR-TB) in adlt. pts. when tmt. cannot otherwise be composed because of resist. or tolerab. See official guid. on use of antibact. agents.
C/I:Hypersens.
Other Cephalosporins & Penems. Ceftaroline Fosamil 600 mg. VIAL.: 10. The recommend. tmt. durat. for cSSTI is 5 to 14 days and the recommend. durat. of tmt. for CAP is 5 to 7 days.
Adult. with normal ren. func., (CrCL) > 50 mL/min: cSSTI, CAP-600 mg, infus. 60 min. every 12 hrs.
Ped. pts. with norm. ren. func., (CrCL) > 50 mL/min. (Calculat. using the Schwartz form. (in mL/min/1.73 m²) for paed. pts.).
cSSTI: Adolesc. aged 12 to<18 yrs. with bdy. wt.≥33 kg-600mg, infus. 60 min. every 12 hrs.
Adolesc. 12 yrs. to<18 yrs. bdy. wt.<33 kg and child.≥2 yrs. to<12 yrs Calculat. using the Schwartz form. (in mL/min/1.73 m²) for paed. pts.) -12 mg/kg to a max. of 400 mg, infus. 60 min. every 8 hrs.
CAP: Infant.≥2 mnths. to<2 yrs.- 8 mg/kg, infus. 60 min every 8 hrs.
Dosage in adults & adolesc. with impair. ren. func., (CrCL)≤ 50 mL/min: See lit.
Indicated in adult. & child. from age of 2 mnths. for the tmt. of the following infec.:
Complic. skin&soft tissue infec. (cSSTI).
Community-acquir. pneumon. (CAP) Consider. should be given to official guidance on the appropriate use of antibact. agents.
C/I: Hypersens. to the act. subst. or it’s excip. Hypersens. to the cephalosp. class of antib. Anaphyl. react. to any other type of beta-lactam antib. (e.g. penicillins or carbapenems.).
