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  • Antituberculosis and Antileprotic Preparations
    2 Drugs classified under this therapeutic system

    All the Therapeutic System Drugs

    partial basket chart

    Antitubercular Agent. 4-Aminosalicylic Acid 4 g.
    SACHETS (gastro-resist. granul.): 30. Adult.: 4 g (one sachet) ×3/d. The recomm. schedule is 4 g every 8 hrs., can be taken with food. Max. dly. dose is 12 g. Usual durat. of tmt. is 24 mnths.
    Ped. popul.: The optimal dose regim. in child. is uncertain. Limited pharmacokin. data suggest no substant. difference betwn. adult. & child.
    For infants, child. & adolesc. the dosage will be adapted to the pt’s. weight at 150 mg/kg/d, divided in two intakes. A dosing spoon is provid. to measure small doses below 4g for young child. See lit.
    Indicated for use as part of an appropriate combin. regimen for multi-drug resist. tuberculos. in adult. & ped. pts. from 28 d. of age and older when an effective tmt. regimen cannot otherwise be compos. for reasons of resist. or tolerab.
    Consid. should be given to official guidance on the appropriate use of antibacter. agents.
    C/I: Hypersens. Severe ren. dis. Pts. with severe renal impair. should not receive GRANUPAS. Patients with severe renal dis. will accumulate the inactive acetyl metabolite of 4-aminosalicylic acid.

    partial basket chart

    Antibiotics. Rifabutin 150 mg.
    HARD CAPS.: 30.
    Gener. Admin. as a single, dly., oral
    dose at any time independ. of meals.
    Adult.: As monother.- Prophyl. of MAC
    infec. in immune-depres. Pts.: 300 mg
    (2 caps.).
    In comb. regimens: Non-tuberc.
    mycobact. dis.: 450-600 mg (3 to 4
    caps.) for up to 6 mnths. after negat.
    cultures are obtained.
    MAC tmt.: in comb with clarithromycin,
    the dosage of Rifabutin should be
    reduced to 300 mg after the 1st month
    of tmt.
    Pulmon. tuberculosis: 150 mg dly. (1
    cap.), for 6-9 mnths., or for at least 6
    mnths. after negat.cultures are
    obtained. Should be incr. to 300-450
    mg/d in pts. prev. treated with
    antituberculous drugs.
    Chron. tuberculosis where there is firm
    evidence of acid fast bacteria resist. to
    Rifampicin or to two other alternative
    Tmt. of infec. caused by MAC or other
    atyp. mycobact. where there is evidence
    of resist. bacteria as above.
    Tmt. of infec. caused by MAC or other
    atypical mycobact. in AIDS pts. in all
    cases not subject to the above
    Preven. of MAC infect. in AIDS pts. whose
    CD4 counts lower or eqval to 200mm3.
    C/I: Hypersens. /hist. of hypersens. to
    the active substance, other rifamycins
    (e.g. rifampicin). Preg. & lact. Child.

    Other therapeutic systems under Infections