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  • Immuno- Suppressants
    15 Drugs classified under this therapeutic system


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    Advagraf
    Astellas
    RX
    partial basket chart
    Advagraf

    Calcineurin Inhibitors, Immunosuppressant. Tacrolimus 0.5, 1, 3, 5 mg.
    P.R. HARD CAPS.: 30, 50, 100.
    Prophyl. of kidney transplant reject. init.
    0.20 - 0.30 mg/kg/d once dly. in the
    morning. Administ. should init. within 24
    h. after the complet.of surgery.
    Prophyl. of liver transplant reject. : init.
    0.10 - 0.20 mg/kg/day once dly. in the
    morning. Administ. should init. approx.
    12-18 h. after the complet. of surgery
    Dosage must. be ajust. individ. Once
    dly, in the morning, on empty stomach
    (at least 1 h. bef. or 2-3 h after a meal).
    See lit.
    Prophyl. of transplant reject. in adult
    kidney or liver allograft recip. Tmt. of
    allograft reject. resistant to tmt. with
    other immunosuppres. med. in adult
    kidney or liver allograft recip. pts.
    C/I: Hypersens., hypersens. to other
    macrolides.

    Cellcept
    Roche
    RX
    partial basket chart
    Cellcept

    Immunosuppressant. Mycophenolate Mofetil 250 mg, 500 mg.
    CAPS: 100 x 250 mg.
    F.C. TABS: 50 x 500 mg. Dosage must me
    adjust. individ. accord. to indication and pt medic. condit. See lit.
    Concom. use with cyclosporine and
    corticosteroids for proph. of organ reject.
    in pts. receiv. allogen. ren., card. and
    hepat. transplants.
    C/I: Hypersensitivity to mycophenolate
    mofetil /mycophenolic acid. Lact.
    WOCBP who are not using highly
    effective contracept. Mycophenolate
    mofetil tmt. should not be init. in
    WOCBP without providing a preg. test
    result to rule out unintended use in
    preg. Mycophenolate mofetil should not
    be used during preg. unless there is no
    suitable alternative tmt. to prevent
    transplant rejection.

    Certican
    Novartis
    RX
    partial basket chart
    Certican

    Immunosuppressant. Everolimus 0.25, 0.5, 0.75 mg.
    TABS: 60 x 0.25 mg, 0.5 mg, 0.75 mg.
    Initial: Gen. kidney and heart
    transplant: 0.75 mg b.i.d. as soon as
    possible aft. transplant in 2 div. doses
    consistently with/out food and at same
    time as cyclosporin for microemuls., to
    be swallowed whole with glass of
    water. May adjust dose at 4-5 day
    intervals. See lit.
    Proph. organ reject. in adult pts at lowmod.
    immunolog. risk receiv. allogeneic
    ren./cardiac transplant, in combinat.
    with cyclosporin for microemuls. and
    corticosteroids. Proph. organ reject. in
    hepat. transplant, in combinat. with
    tacrolimus and corticosteroids.
    C/I: Hypersens. to everolimus, sirolimus
    or any of the excips.
    experienced in immunosuppress. ther.
    See lit.

    Deximune 25, 50, 100 mg
    Dexcel
    RX
    full basket chart
    Deximune 25, 50, 100 mg

    Immunosuppressant. Cyclosporine 25, 50, 100 mg.
    CAPS: 50 x 25 mg, 50 mg, 100 mg. 2 div.
    doses dly. See lit.
    Prophylax. organ reject. kidney, liver,
    heart allogenic tranplants in conjunct.
    with corticosteroids. May also be used in
    the tmt. of chron. rejects. in pts previously
    treated with other immunosuppress.
    agents. Bone marrow transplant., endog.
    uveit., severe psoriasis above age 16 that
    does not respond to other tmt. Atopic
    dermatit. in adults only up to 8 wks.,
    severe cases in which convention. ther. is
    ineffect. or inapprop. Severe cases rheum.
    arthrit., when standard tmt. ineffect. or
    inapprop. Nephrot. syndr. type MCD
    (minimal change dis.) when convention.
    ther. failed.
    C/I: Hypersens. to active subs., excips.,
    lact., pts. atopic dermatit. and psoriasis
    with impair. kidney funct., unstable BP,
    uncontrol. infect./any type malign.
    except certain skin tumors req. biopsy
    prior use; pts. rheum. arthrit. with impair.
    kidney funct., unstable BP, uncontrol.
    infect./any type malign., pts <18 yrs.
    Concurr. with tacrolimus, rosuvastatin.
    Pts. with nephrot. syndr. with unstable
    BP, uncontrol. infect./any type malign.
    See lit.

    Imuran 25 mg, 50 mg
    Perrigo
    RX
    full basket chart
    Imuran 25 mg, 50 mg

    Immunosuppressant. Azathioprine 25 mg, 50 mg.
    F.C. TABS: 10 x 25 mg, 100 x 50 mg. 2-5 mg/kg dly. depend. on cond. and response of pt.
    Renal transplant, rheum. arthrit.
    C/I: Liver damage, history of hepatit.,
    pregn., except in special circumstance.

    Mycophenolate Teva
    Teva
    RX
    partial basket chart
    Mycophenolate Teva

    Immunosuppressant. Mycophenolate Mofetil 500 mg.
    TABS: 10, 30, 50, 60. Tmt to be initiated
    and maintain. by appropriat. qualified
    transplant specialists. Ren. transplant:
    Initiate tmt within 72 hrs follow surg: 1
    g 2 x dly. Child/adolesc (2-18 yrs): 600
    mg/m2 2 x dly, max 2 g dly. Child under
    2 yrs: Not recommend. Cardiac/hepatic
    transplant: Initiate tmt within 5 days
    follow. surgery: 1.5 g 2 x dly. Children:
    Not recommend. Elderly (>65 yrs): Ren.
    transplant: 1 g 2 x dly; cardiac/hepat.
    transplant: 1.5 g 2 x dly. Severe chronic
    ren. impair: Max 1 g 2 x dly. Pts to be
    carefully observed. No data avail. for
    card./hepat. transplant in severe
    chron. ren. impair. Severe hepat.
    impair: See lit. Tmt during reject.
    episodes: Dos. reduct/interrupt. not
    reqd. See lit.
    Proph. organ reject. in pts. receiv.
    allogen. ren. and card. and hepat.
    transplants.


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