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  • Acrolimus
    / Teva Israel LTD, Israel


    Active Ingredient
    Tacrolimus 0.5, 1, 3, 5 mg

    Status in Israel
    RX

    Presentation and Status in Health Basket

    Presentation Basket Yarpa Pharmasoft

    Prolonged-Release Capsules

    50 x 0.5 mg

    partial basket chart

    Prolonged-Release Capsules

    50 x 1 mg

    partial basket chart

    Prolonged-Release Capsules

    50 x 3 mg

    partial basket chart

    Prolonged-Release Capsules

    50 x 5 mg

    partial basket chart

    Related information


    Dosage

    The generally accepted dosage is: Take this medicine once a day.
    * You should make sure that you receive the same tacrolimus preparation every time you get the medicine dispensed.
    * The starting dose to prevent the rejection of the transplanted organ will be calculated according to your body weight. The starting dose after transplantation is usually 0.1-0.3 mg per kg body weight per day, depending on the transplanted organ.
    The dosage intended for the treatment of transplant rejection is the same.
    * The dosage you receive depends on your general condition and on the type of additional immunosuppressive medications you are taking.
    * You should take this medical products daily, as long as you need immunosuppressive treatment to prevent transplant rejection. After starting treatment with this medical product, have frequent blood tests in order to determine the correct dosage. Afterwards, blood tests will be required periodically in order to determine the correct dosage and to adjust the dosage from time to time.
    Please refer to the license holder for further details.


    Indications

    Prevention of transplant rejection after kidney or liver transplant.
    Treatment of transplant rejection, after kidney or liver transplant, when there is resistance to other immunosuppressive medicines.


    Contra-Indications

    * Hypersensitivity to the active substances or to any of the excipients.
    * Hypersensitivity to Sirolimus or to macrolide antibiotics (such as Erythromycin, Clarithromycin, Josamycin).


    Special Precautions

    * Potential QT prolongation
    * Avoid direct contact with any part of your body such as the skin or eyes, or inhalation of the injection solution, powder or granules included in tacrolimus preparations. If such contact occurs, wash the skin and eyes
    Please refer to the license holder for further details.


    Side Effects

    The most commonly reported adverse reactions are hyperglycaemic conditions, diabetes, hyperkalaemia, insomnia, tremors, headaches, hypertension, abnormal liver function test results, diarrhea, nausea, and kidney impairment.
    Other common sever adverse reactions:
    Gastrointestinal perforation, impaired function of the transplanted organ, blurred vision.
    Please refer to the license holder for further details.


    Drug interactions

    Please refer to the license holder for further details


    Pregnancy and Lactation

    Please refer to the license holder for further details.     


    Overdose

    Please refer to the license holder for further details.     


    Important notes

    Do not replace with another tacrolimus preparation, unless the doctor from the transplant clinic approves it.


    Manufacturer
    Teva Israel LTD, Israel
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