All the Drug Class Drugs
Calcineurin Inhibitors, Immunosuppressant. Tacrolimus 0.5, 1, 3, 5 mg. P.R. HARD CAPS.: 30, 50, 100.
Prophyl. of kidney transplant reject. init.
0.20 - 0.30 mg/kg/d once dly. in the
morning. Administ. should init. within 24
h. after the complet.of surgery.
Prophyl. of liver transplant reject. : init.
0.10 - 0.20 mg/kg/day once dly. in the
morning. Administ. should init. approx.
12-18 h. after the complet. of surgery
Dosage must. be ajust. individ. Once
dly, in the morning, on empty stomach
(at least 1 h. bef. or 2-3 h after a meal).
Prophyl. of transplant reject. in adult
kidney or liver allograft recip. Tmt. of
allograft reject. resistant to tmt. with
other immunosuppres. med. in adult
kidney or liver allograft recip. pts.
C/I: Hypersens., hypersens. to other
Immunosuppressant. Mycophenolate Mofetil 250 mg, 500 mg. CAPS: 100 x 250 mg.
F.C. TABS: 50 x 500 mg. Dosage must me
adjust. individ. accord. to indication and pt medic. condit. See lit.
Concom. use with cyclosporine and
corticosteroids for proph. of organ reject.
in pts. receiv. allogen. ren., card. and
C/I: Hypersensitivity to mycophenolate
mofetil /mycophenolic acid. Lact.
WOCBP who are not using highly
effective contracept. Mycophenolate
mofetil tmt. should not be init. in
WOCBP without providing a preg. test
result to rule out unintended use in
preg. Mycophenolate mofetil should not
be used during preg. unless there is no
suitable alternative tmt. to prevent
Immunosuppressant. Everolimus 0.25, 0.5, 0.75 mg. TABS: 60 x 0.25 mg, 0.5 mg, 0.75 mg.
Initial: Gen. kidney and heart
transplant: 0.75 mg b.i.d. as soon as
possible aft. transplant in 2 div. doses
consistently with/out food and at same
time as cyclosporin for microemuls., to
be swallowed whole with glass of
water. May adjust dose at 4-5 day
intervals. See lit.
Proph. organ reject. in adult pts at lowmod.
immunolog. risk receiv. allogeneic
ren./cardiac transplant, in combinat.
with cyclosporin for microemuls. and
corticosteroids. Proph. organ reject. in
hepat. transplant, in combinat. with
tacrolimus and corticosteroids.
C/I: Hypersens. to everolimus, sirolimus
or any of the excips.
experienced in immunosuppress. ther.
Immunosuppressant. Cyclosporine 25, 50, 100 mg. CAPS: 50 x 25 mg, 50 mg, 100 mg. 2 div.
doses dly. See lit.
Prophylax. organ reject. kidney, liver,
heart allogenic tranplants in conjunct.
with corticosteroids. May also be used in
the tmt. of chron. rejects. in pts previously
treated with other immunosuppress.
agents. Bone marrow transplant., endog.
uveit., severe psoriasis above age 16 that
does not respond to other tmt. Atopic
dermatit. in adults only up to 8 wks.,
severe cases in which convention. ther. is
ineffect. or inapprop. Severe cases rheum.
arthrit., when standard tmt. ineffect. or
inapprop. Nephrot. syndr. type MCD
(minimal change dis.) when convention.
C/I: Hypersens. Comb. with Hypericum perforatum (St John’s wort). Comb. with substrates for the multidrug efflux transporter P-gp or the organ. anion transport. proteins and for which elevat. plasma conc. are assoc. with serious and/or life-threaten. events, e.g. bosentan, dabigatran etexilate, aliskiren. see lit.
Immunosuppressant. Pirfenidone 267 mg. HARD CAPS.: 252, 270. The recom. dly.
dose is 801 mg(3 caps.) × 3/d with food
for a total of 2403 mg/day. See lit.
Tmt. of mild to moder. idiop. pulmon.
fibrosis in adult.
C/I: Hypersens. Hist.of angioed. with
pirfenidone. Concom. use of fluvoxamine. Sev. hep. impair. or end stage liver dis. Sev. renal impair.(CrCl <30 ml/min) or end stage
renal dis. requir. dialysis.