All the Active Ingredient Drugs
Protein Kinase Inhibitor. Everolimus 2.5, 5, 10 mg. TABS: 30 x 2.5 mg, 5 mg, 10 mg. Tmt. to
be initiated by physician experienced
in the use of anticancer ther. Orally
once dly., at the same time ev. d. See
Tmt. pts. with advanced ren. cell
carcinoma aft. fail. of tmt. with sunitinib or
sorafenib. Tmt. pts. with SEGA assoc. with
tuberous sclerosis complex who req. ther.
but not candidates for curative surg.
resect. Effect. based on analys. of change
in SEGA vol. Clin. benefit in improvement
dis.-relat,. sympts/increase in overall
survival has not been demonstrat. Tmt.
progress. neuroendocrine tumors
pancreat. origin in pts. with unresect.,
locally advanced/metastat. dis. Safety/
effectivenss in tmt. carcinoid tumors have
not been established. Tmt. of horm.
receptor-pos., HER2/neu neg. advanc.
breast canc. in combi. with exemestane in
postmen. women w/o symp. visceral dis.
after recur. or progress. following nonsteroid.
aromat. inh.. Tmt. of adult pts.
with renal angiomyolipoma and tuberous
sclerosis comp., nor req. immediate surg.
Effectiv. of the drug in tmt. of renal
angiomyolipoma based on an analysis of
durable obj. respons. in pts. treat. for a
median of 8.3 mnths. Further follow-up of
pts. is req. to determine long-term
Tmt. of unresect., local. advanc. /metastat.,
well-different. (Grade 1/ Grade 2) nonfunct.
neuroendocrine tumour. of GI or
lung origin in adults with progress. dis.
C/I: Hypersens. to active substances,
other rapamycin derivs., excips.
Immunosuppressant. Everolimus 0.25, 0.5, 0.75 mg. TABS: 60 x 0.25 mg, 0.5 mg, 0.75 mg.
Initial: Gen. kidney and heart
transplant: 0.75 mg b.i.d. as soon as
possible aft. transplant in 2 div. doses
consistently with/out food and at same
time as cyclosporin for microemuls., to
be swallowed whole with glass of
water. May adjust dose at 4-5 day
intervals. See lit.
Proph. organ reject. in adult pts at lowmod.
immunolog. risk receiv. allogeneic
ren./cardiac transplant, in combinat.
with cyclosporin for microemuls. and
corticosteroids. Proph. organ reject. in
hepat. transplant, in combinat. with
tacrolimus and corticosteroids.
C/I: Hypersens. to everolimus, sirolimus
or any of the excips.
experienced in immunosuppress. ther.