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  • Everolimus
    2 Drugs classified under this active ingredient


    All the Active Ingredient Drugs

    Afinitor
    Novartis
    RX
    partial basket chart
    Afinitor

    Protein Kinase Inhibitor. Everolimus 2.5, 5, 10 mg.
    TABS: 30 x 2.5 mg, 5 mg, 10 mg. Tmt. to
    be initiated by physician experienced
    in the use of anticancer ther. Orally
    once dly., at the same time ev. d. See
    lit.
    Tmt. pts. with advanced ren. cell
    carcinoma aft. fail. of tmt. with sunitinib or
    sorafenib. Tmt. pts. with SEGA assoc. with
    tuberous sclerosis complex who req. ther.
    intervent.
    but not candidates for curative surg.
    resect. Effect. based on analys. of change
    in SEGA vol. Clin. benefit in improvement
    dis.-relat,. sympts/increase in overall
    survival has not been demonstrat. Tmt.
    progress. neuroendocrine tumors
    pancreat. origin in pts. with unresect.,
    locally advanced/metastat. dis. Safety/
    effectivenss in tmt. carcinoid tumors have
    not been established. Tmt. of horm.
    receptor-pos., HER2/neu neg. advanc.
    breast canc. in combi. with exemestane in
    postmen. women w/o symp. visceral dis.
    after recur. or progress. following nonsteroid.
    aromat. inh.. Tmt. of adult pts.
    with renal angiomyolipoma and tuberous
    sclerosis comp., nor req. immediate surg.
    Effectiv. of the drug in tmt. of renal
    angiomyolipoma based on an analysis of
    durable obj. respons. in pts. treat. for a
    median of 8.3 mnths. Further follow-up of
    pts. is req. to determine long-term
    outcomes.
    Tmt. of unresect., local. advanc. /metastat.,
    well-different. (Grade 1/ Grade 2) nonfunct.
    neuroendocrine tumour. of GI or
    lung origin in adults with progress. dis.
    C/I: Hypersens. to active substances,
    other rapamycin derivs., excips.

    Certican
    Novartis
    RX
    partial basket chart
    Certican

    Immunosuppressant. Everolimus 0.25, 0.5, 0.75 mg.
    TABS: 60 x 0.25 mg, 0.5 mg, 0.75 mg.
    Initial: Gen. kidney and heart
    transplant: 0.75 mg b.i.d. as soon as
    possible aft. transplant in 2 div. doses
    consistently with/out food and at same
    time as cyclosporin for microemuls., to
    be swallowed whole with glass of
    water. May adjust dose at 4-5 day
    intervals. See lit.
    Proph. organ reject. in adult pts at lowmod.
    immunolog. risk receiv. allogeneic
    ren./cardiac transplant, in combinat.
    with cyclosporin for microemuls. and
    corticosteroids. Proph. organ reject. in
    hepat. transplant, in combinat. with
    tacrolimus and corticosteroids.
    C/I: Hypersens. to everolimus, sirolimus
    or any of the excips.
    experienced in immunosuppress. ther.
    See lit.

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