Cyclosporine

4 Drugs classified under this active ingredient

Immunosuppressant. Cyclosporine 25, 50, 100 mg.
CAPS: 50 x 25 mg, 50 mg, 100 mg. 2 div.
doses dly. See lit.
Prophylax. organ reject. kidney, liver,
heart allogenic tranplants in conjunct.
with corticosteroids. May also be used in
the tmt. of chron. rejects. in pts previously
treated with other immunosuppress.
agents. Bone marrow transplant., endog.
uveit., severe psoriasis above age 16 that
does not respond to other tmt. Atopic
dermatit. in adults only up to 8 wks.,
severe cases in which convention. ther. is
ineffect. or inapprop. Severe cases rheum.
arthrit., when standard tmt. ineffect. or
inapprop. Nephrot. syndr. type MCD
(minimal change dis.) when convention.
ther. failed.
C/I: Hypersens. to active subs., excips.,
lact., pts. atopic dermatit. and psoriasis
with impair. kidney funct., unstable BP,
uncontrol. infect./any type malign.
except certain skin tumors req. biopsy
prior use; pts. rheum. arthrit. with impair.
kidney funct., unstable BP, uncontrol.
infect./any type malign., pts <18 yrs.
Concurr. with tacrolimus, rosuvastatin.
Pts. with nephrot. syndr. with unstable
BP, uncontrol. infect./any type malign.
See lit.

Cyclosporine. Cyclosporine 0.05%.
SINGLE USE VIALS: 32 x 0.4 ml. 1 drop 2
x dly into ea. eye ±12 hrs. apart. Can be
used concom. with artificial tears;
allow 15 min. betw. products.
Incr. tear product. due to ocular inflamm.
assoc. with keratoconjuntivit.
C/I: Active ocular infect., hypersens.,
while wearing contact lenses, pregn.
lact. child under 16 yrs.

Immunosuppressant. Cyclosporine 50 mg/ml.
AMPS: 10 x 5 ml. See lit.
Proph. organ reject. kidney, liver, heart
allogen. transplants in conjunct. with
corticosteroids., chron. reject. in pts
previously treated with other
immunosuppress.
agents, bone marrow transplant.
C/I: Known hypersens. to cyclosporine
and/or polyoxyethylated castor oil.

Immunosuppressant. Cyclosporine 25, 50, 100 mg.
SOFT GELATINE CAPS: 50 x 25 mg, 50
mg, 100 mg. 2 div. doses dly. See lit.
SOLN: 50 ml x 100 mg/ml. 2 div. doses
dly. Dosage must be ajust. individ.
accord. to pt. med. cond.
Solid organ transplant., bone marrow
transplant, endog. uveitis, severe
psoriasis, above age 16 that did not
respond to other treatment; atopic
dermatit. in adults for only up to 8 wks,
for severe cases in which conventional
ther. ineffect. / inapprop., rheum. arthrit:
severe cases when standard tmt. ineffect.
/ inapprop., nephrotic syndr. type MCD
(minimal change disease) in cases where
conventional ther. has failed.
C/I: Hypersens. Comb. with Hypericum
perforatum (St John´s Wort).
Comb. with substrates for the multidrug
efflux transporter P-gp or the organ.
anion transport. proteins and for which
elevat. plasma conc. are assoc. with
serious and/or life-threaten. events, e.g.
bosentan, dabigatran etexilate, aliskiren.