All the Active Ingredient Drugs
Calcineurin Inhibitors, Immunosuppressant. Tacrolimus 0.5, 1, 3, 5 mg. P.R. HARD CAPS.: 30, 50, 100.
Prophyl. of kidney transplant reject. init.
0.20 - 0.30 mg/kg/d once dly. in the
morning. Administ. should init. within 24
h. after the complet.of surgery.
Prophyl. of liver transplant reject. : init.
0.10 - 0.20 mg/kg/day once dly. in the
morning. Administ. should init. approx.
12-18 h. after the complet. of surgery
Dosage must. be ajust. individ. Once
dly, in the morning, on empty stomach
(at least 1 h. bef. or 2-3 h after a meal).
See lit.
Prophyl. of transplant reject. in adult
kidney or liver allograft recip. Tmt. of
allograft reject. resistant to tmt. with
other immunosuppres. med. in adult
kidney or liver allograft recip. pts.
C/I: Hypersens., hypersens. to other
macrolides.
Immunosuppressant. Tacrolimus 0.5, 1, 5 mg. CAPS: 50, 100 x 0.5 mg, 1 mg; 50 x 5 mg.
CONC. FOR INFUS: 10 amps x 1 ml x 5
Dosage must be ajust. individ.
accord. med. cond. of the pt.
Proph. transplant reject. liver, kidney,
heart allograft recips. Tmt. allograft reject.
resist. to tmt. with other immunosuppress.
medicin. products.
C/I: Hypersens., Hypersens. to
polyoxyethylene hydrogenated castor
oil or structurally related compound.
Immunomodulator. Tacrolimus 0.03%. OINT: 30 g. Apply a thin layer to affect.
skin (on any part of the body, incl. face,
neck and flexure areas, except on
mucous membranes). Not to be
applied under occlus. Cont. tmt. until
clearance occurs. Generally,
improvement is seen within 1 wk. of
start of tmt. If no signs of improve.
seen aft. 2 wks., further tmt. options
should be considered. Can be used for
short term and intermitt. long term
tmt. Adult (16 yrs and over): Initial: 2 x
dly for up to 3 wks. Treat till clearance
of lesion. Maint. tmt: Apply 1 x dly,
twice wkly, wait 2-3 days betw. tmts.
See lit. Elderly (65 yrs and over): Dos.
adjust. not necess. Child (2 yrs and
over): Initial: 2 x dly for up to 3 wks.
Then transfer to 1 x dly till clearance of
lesion. Maint. tmt: Apply 1 x dly, twice
wkly, wait 2-3 days btw. tmts. See lit.
Tmt. mod. to severe atop. dermatit. in
adults who are not adequat. respons. to or
are intol. of convent. ther. Tmt. mod. to
severe atop. dermatit. in child (2 yrs and
over) who failed to respond adequat. to
convent. ther. Maint. tmt. for prevent.
flares/prolongat. flare-free intervals. See
lit.
Immunomodulator. Tacrolimus 0.1%. OINT: 30 g. Apply thin layer to affect.
skin (on any part of the body, incl. face,
neck and flexure areas, except on
mucous membranes). Not to be
applied under occlus. Cont. tmt. until
clearance occurs. Generally,
improvement is seen within 1 wk. of
start of tmt. If no signs of improve.
seen aft. 2 wks., further tmt. options
should be considered. Can be used for
short term and intermitt. long term
tmt. Adults (16 yrs and over): Initial: 2 x
dly for up to 3 wks. Then transfer to
Protopic 0.03% 2 x dly. Maint. tmt:
Apply 1 x dly, 2 x wkly, wait 2-3 days
betw. tmts. See lit. Cont. tmt. till
clearance of lesion. Elderly (65 and
over): As above. Dos. adjust. not
necess.
Tmt. mod. to severe atop. dermatit. in
adults who are not adequat. respons. to or
are intol. of convent. ther. Maint. tmt. for
prevent. flares/prolongat. flare-free
intervals. See lit.
Immunosuppressant. Tacrolimus (as monohydrate) 0.5, 1, 5 mg. CAPS: 10, 30, 50, 60, 100. 1 cap 2 x dly,
on empty stomach > 1 hr bef. or 2-3
hrs. aft. meal. Not with grapefruit/
grapefruit juice. Not to be chewed/
opened. Swallow. with glass water
immed. foll. remov. from blister. See lit.
Prophylax. transplant reject. liver, kidney,
heart allograft. Tmt. allograft reject.
resist. to tmt. with other
immunosuppress. med. prods.
C/I: Hypersens. to ingreds., excips.,
macrolides, lact. coadmin. cyclosporine.
