Immunomodulator

13 Drugs classified under this drug class

Immunomodulator. Imiquimod 5%.
CREAM (single sachets): 12. Apply 3 x
wkly at bedt. for up to 16 wks. Leave
6-10 hrs bef. washing off. Actinic
keratoses: Apply prior to sleep for 8 hrs
2/wk for 16 wks to defined area ±25
cm2 (5 cm x 5 cm). SBCC: Apply cream 5
x wkly for 6 wks. See lit.
Ext. genital warts, perianal warts
(condyloma acuminata), actinic keratoses.
Top. tmt. biopsy confirmed, prim. ficial
basal cell carcinoma. See lit.
C/I: Use in pregn. only if benefit justifies
risk to pt.

Immunomodulator. Imiquimod 5%.
CREAM (sachets): 12 x 0.25 g.
Apply 3 x wkly at bedt. for up to 16 wks.
Leave 6-10 hrs bef. washing off. Actinic
keratoses: Apply prior to sleep for 8 hrs
2/wk for 16 wks to defined area ±25
cm2 (5 cm x 5 cm). SBCC: Apply cream 5
x wkly for 6 wks. See lit.
Tmt. top. ext. genital/ perianal warts
(condyloma acuminata) in adults. Tmt.
actinic dermatoses in adults with normal
immune systems. Tmt. fic. cell carcinoma.
C/I: Hypersens.

Immunomodulator. Interferon Beta-1a 30 mcg.
PRE-FILL. SYR/PEN: 4.
SINGLE-USE VIAL: 4. 1 inject I.M. 1 x
wkly (self-inject. permitted).
Relapse form multiple sclerosis, slow
accumulation of physical disabil., decr.
freq. clinical exacerbations. Tmt. demyelinat. event with active inflamm.
process if severe enough to treat with I.V.
corticoster., if alt. diagn. excluded incl.
MRI abnorm. characters. of MS if at high
risk of develop. clin. defin. MS.
C/I: Hypersens. to natural or
recombinant interferon beta, human
albumin or any other component.

Immunomodulator. Interferon Beta-1b 0.3 mg/vial.
VIALS (pwdr. for sol. for inject.): 15 x 1.2
ml/2.5 ml diluent in prefilled syringe.
See lit.
Relaps.-remitt. MS (RRMS), relaps.-
progress. MS, second. progress. MS,
severe single demyelinat. event with
active inflamm. event + MRI abnormal.
of MS + alt. diagnos. have been
excluded.
C/I: Hypersens. to nat. or recomb.
interferon beta, human albumin/excips.
Severe depress., suicidal ideat., decomp.
liver dis., initial. tmt. in pregn.

Immunomodulator. Glatiramer Acetate 20 mg/ml, 40 mg/ml.
Sol. FOR INJECT: (Prefilled syringes): 28.
20 mg dly S.C. at same time every day.
For self-admin. See lit.
40 mg, administered 3 times a week.
Tmt. pts. who have experienced
welldefined first clin. episode and are
determined to be at high risk of develop.
CDMS. Pts. should have MRI findings
compat. with diagnosis of MS. Reduc.
freq.
of relaps. in pts. with relaps.-remitt. MS.
C/I: Hypersens. to copolymer 1 or
mannitol.

Immunomodulator. Fingolimod HCl 0.5 mg.
HARD CAPS.: 7, 28. For init. ther: See lit.
Recommend. dose: 0.5 mg ×1/d.
Tmt. relaps. forms multiple sclerosis (MS).
Reduct. freq. clin. exacerbat., delay
accumul. phys. disabil.
C/I: Pts. who in the last 6 mths. experien.
MI, unst. angina, stroke, TIA, decompen.
heart fail. requiring hospital. or Class III/
IV heart fail. Hist. or presence of Mobitz
Type II 2nd –degr. or 3rd –degr. AV block
or sick sinus synd., unless pt. has a
function. Pacemaker Baseline QTc inter.
≥500 ms. Tmt. with Class Ia or Class III
anti-arrhythm. drugs.