Teva Israel LTD, Israel

Calcineurin Inhibitors, Immunosuppressant. Tacrolimus 0.5, 1, 3, 5 mg.
PR Caps.50 X0.5/1/3/5 mg
For kidney transpl.: Once dly in the morn., on empty stomach, 0.20 - 0.30 mg/kg within 24 h from surg. complet. Dose to be adjust. as per clinic. assess. For liver transpl.: Once dly in the morn., on empty stomach, 0.10 - 0.20 mg/kg within 12-18 h from surg. complet. Dose to be adjust. as per clinic. assess.
Prophylaxis of transpl. reject. in adult kidney or liver allograft recipts.. Tmt. of allograft reject. resist. to tmt. with other immunosuppress. in adult kidney or liver allograft recip. ptts.
C/I:  Hypersens. incl. other macrolides.

TCA. Amitriptyline 10 mg.
FC tab.X 28
Major depress. disord.  Tmt. should be init. at low level and incr. grad., noting carefully clinic. resp. and evidence of intolerab. Adlts.: init. 25 mg 2 times/d (50 mg/d). If necessary, can be incr. by 25 mg every other d. up to 150 mg/d div.in 2 doses.
Nocturnal enuresis ped. pop.
• childr. aged 6 to 10: 10 mg – 20 mg/d. A suitable dosage form should be used for this age group.
• childr. aged 11 and above: 25 mg – 50 mg/d. Dose should be incr. grad. To be admin. 1-1½ hours before bedtime.
Relief of symptoms of depress. Endogenous depress. is more likely to be
alleviated than other depress. states.
Enuresis nocturna
C/I: Recent MI. Any degree of heart block or disord. of cardiac rhythm and coron. artery insuff./ Concom. tmt. with MAOIs. Tmt. with amitriptyline may start 14 days after discont. of irrevers. non- select. MAOIs and min. one d. after discont. of the revers. moclobemide. Tmt. with MAOIs may be introd. 14 days after discont. of amitriptyline/Sev. liver dis./Childr. under 12 years of age.

Potassium Channel Blocker. Fampridine 10 mg.
PR Tabs 28/56 X 10 mg
One 10 mg tab, twice daily, taken 12 hours apart .
Improvem. of walking in adlt. pts. with MS with walking disab. (EDSS 4-7)
C/I:  Hypersens. Conc. tmt. with other med. prod. contain. fampridine (4-aminopyridine). Pts. with  hist.or current seizures. Pts. with mild, mod. or sev. renal impairm. (creat. clear. <80 ml/min).
Concom. use with inhibit. of Organic Cation
Transporter 2 (OCT2) for ex., cimetidine.

Lansoprazole 30 mg.
Gatro res. caps. 28 X 30 mg
1-2 caps/day for adults and adolesc. aged 12-17
Tmt. of duodenal and gastric ulcer/Tmt. of reflux oesophagitis/
Prophyl. of reflux oesophagitis/ Eradic. of H. pylori concurr. given with  antibiotic ther. for tmt. of H.pylori-assoc. ulcers/
Tmt. of NSAID-assoc. benign gastric and duodenal ulcers in pts. req.continued NSAID tmt./
Prophyl. of NSAID-assoc. gastric ulcers and duodenal ulcers in pts. at risk req. continued ther/ Symptom. gastroesophageal reflux dis./
Zollinger-Ellison syndr.
C/I: Hypersens. Concom. use with rilpivirine

Serotonin 2C Receptor Agonist. Palonosetron 0.05 mg/mi.
Vial, Sol for IV inf., 1X 5ml
250 microg admin. as a sgle IV bolus approx. 30 min. before  start of chemother. to be inject. over 30 seconds. The efficacy of this drug in the prevent. of nausea and vomit. induced by highly emetogenic chemother. may be enhanced by the addit. of a corticoster. admin. prior to chemother. Child. and adolesc. (aged 1 month to 17 years): 20 microg/kg (max. total dose should not exceed 1500 microg) palonosetron admin. as a sgle 15 min. IV infus. beginning approx. 30 min. before start of chemother.
In adlts and in paed. ptts. 1 month of age and older for the prevent. of ac. nausea and vomit. assoc. with highly emetogenic cancer chemotherapy, and prevent. of nausea and vomit. assoc. with moder. emetogenic cancer chemotherapy.
C/I: Hypersens.

Folic Acid Analog. Pemetrexed (as diacid monohydrate) 25 mg/ml.
Sol for IV inf. 1 X  4/20/34/40 ml . Dose 500 mg/m² of body surface area (BSA) admin. as an IV inf. over 10 min. on the first day of each 21-day cycle. See lit.
In comb. with cisplatin, for the tmt. of pts with malign. pleural mesothelioma whose dis. is unresect. or who are not candid. for curatible surg. In combin. with cisplatin, for the first line tmt. of pts with locally adv. or metast. non-small cell lung canc. (NSCLC) other than predomin. squam. cell histol. As monother. for the sec. line tmt. of pts with locally adv. or metast. NSCLC other than predom. squam. cell histol. As monother. for the maint. tmt. of locally adv. or metast. NSCLC other than predom. squam. cell histol. in pts whose dis. has not progr. immediate. follow. platinum-based chemother.
C/I: Hypersens. Lact. Concom. yellow fever vacc.