All the Therapeutic System Drugs
Folic Acid Inhibitor, Sulfonamide. Sulphamethoxazole 200 mg / 5 ml, Trimethoprim 40 mg / 5 ml. PED. SUSP: 100 ml. Child: 10 kg: 1
teasp. 2 x dly. 20 kg: 2 teasp. 2 x dly.
30 kg: 3 teasp. 2 x dly. 40 kg: 4 teasp. 2
x dly. Pneumocyt. carinii pneumonit:
8 kg: 1 teasp; 16 kg: 2 teasp; 24 kg: 3
teasp; 32 kg: 4 teasp. All every 6 hrs.
Tmt of UTIs due to suscept. strains of the
foll. organ.: Escherichia coli, Klebsiella,
Enterobacter, Proteus mirabilis, Proteus
vulgaris and Proteus morganii. Tmt of
acute otitis media in child. due to suscept.
strains of Hemophilus influenzae or
Streptococcus pneumoniae. To date,
limit. data is avail. on the safety of repeat.
use in infants under 2 yrs. It is not indic.
for prophyl. or prolong. admin. in otitis
media at any age. Tmt of acute exacerb.
of chronic bronchitis due to suscept.
strains of Hemophilus influenzae or
Streptococcus pneumoniae. Tmt of
enteritis caus. by suscept. strains of
Shigella flexneri and Shigella sonnei. Tmt
of docum. Pneumocystis carinii
C/I: Hypersens. to trimethoprim or
sulfonamides or to any ingred. of the prep.
Pts with mark. liver parenchymal damage.
Pts with sev. renal insuff. where repeat.
measur. of the plasma conc. cannot be
performed. Pregn. at term, lact., in prem.
babies and dur. the first 2 mnths of life.
Docum. megaloblastic anemia due to folate
Folic Acid Inhibitor, Sulfonamide. Sulphamethoxazole 400 mg / 5 ml, Trimethoprim 80 mg / 5 ml. AMPS: 10 x 5 ml.
I.V. infusion only. Adults and child over
2 yrs: 2 amps (10 ml) every 12 hrs. Child
12 yrs. and under: Approx. 6 mg
trimethoprim and 30 mg
sulphamethoxazole/kg bdy. wt. every
24 hrs. in eq. div. doses. As a guide: 6
wks. - 5 mths: 1.25 ml every 12 hrs.; 6
mths. - 5 yrs: 2.5 ml every 12 hrs., 6 - 12
yrs: 5.0 ml every 12 hrs. See lit. Severe
infects. all age groups: Incr. by 50%.
Cont. tmt. until pt. sympt. free for 2
days. Usual tmt: At least 5 days. See lit.
for use in elderly, impair. ren. funct.,
pneumocyst. carinii pneumonit.
Bact. infects., infects. respir., gastrointest.
C/I: Hypersens., liver parenchymal
damage, serious hematolog. disords.,
severe ren. impair., prem. babies.
Oxazolidinone. Linezolid 600 mg, 2 mg/ml. F.C.TABS: 10.
INFUS. SOLN: 300 ml x 2 mg/ml. Infus.
over 30-120 mins. Commun. acq./
nosocomial pneum, includ. concurrent
bacterem.; complicat. skin/skin
structure infects., including diabetic
foot infects: Adults/ adolesc. (12 yrs
and older): 600 mg I.V./oral every 12
hrs for 10-14 days. Ped. pts: 10 mg/kg
I.V./oral every 8 hrs for 10-14 days.
Vancomycin resist. infects. (incl.
concurrent bacterem.): Adults/
adolescents (12 yrs and older): 600 mg
I.V./oral every 12 hrs for 14-28 days.
Ped. pts: 10 mg/kg I.V./oral every 8 hrs
for 14-28 days. Uncomplicat. skin/skin
structure infects: Adults: 400 mg oral
every 12 hrs; Adolesc. 600 mg oral
every 12 hrs, both for 10-14 days. Ped.
pts: < 5 yrs: 10 mg/kg oral every 8 hrs;
5-11 yrs: 10 mg/kg oral every 12 hrs;
both for 10-14 days. Neonates <7 days:
10 mg/kg every 12 hrs. See lit. MRSA:
Adults: 600 mg every 12 hrs.
Indic. in adult & ped. pts. for the tmt. of
infect. when known or suspect. to be
caused by suscept. organisms includ.
those assoc. with concur. bacteraemia
Pneum. commun. acquir. and nosocom.
pneum. includ. MDRSP.
Skin&soft tissue infec. include. diabetic
Enterococcal infec. Comb. ther. may be
indicated if a concom. Gram neg.
pathogen is document. or suspect.
Concom. use with MAOi A or B (e.g.
phenelzine, moclobemide) or within 2
wks. of taking any such drug.
Pts. with uncontrol. hypertens. ,
and/or pts. taking any of the follow. types of meds.: direct./ indirect. act.
sympathom. agents (e.g.,
agents (e.g., epinephrine,
norepinephrine), dopaminergic agents
(e.g., dopamine, dobutamine).