Antiretrovirals

3 Drugs classified under this drug class

Antiretrovirals. Bictegravir 50 mg, Emtricitabine 200 mg, Tenofovir Alafenamide 25 mg.
F.C. TABS.: 30. 1 tab×1/d with/without
food. If the patient misses a dose
within 18 hours of the time it is
usually taken, the patient should take
the drug as soon as possible and
resume the normal dosing schedule.
If a patient misses a dose by more
than 18 hours, the patient should not
take the missed dose and simply
resume the usual dosing schedule.
If the patient vomits within 1 hour of
taking the drug another tablet should
be taken. If a patient vomits more
than 1 hour after taking the drug they
do not need to take another dose of
the drug until the next regularly
scheduled dose.
Treatment of adults infected with human
immunodeficiency virus-1 (HIV-1) without
present or past evidence of viral resistance
to the integrase inhibitor class,
emtricitabine or tenofovir.
C/I: Hypersens.
Co-admin. with rifampicin and St John’s
wort (Hypericum perforatum).

Antiretrovirals. Emtricitabine 200 mg, Elvitegravir 150 mg, Cobicistat 150 mg.
FILM COAT. TABS.:30.
Adult., paed. 6 yrs. and older, wt. at least 25 kg: 1 tab. ×1/d with food. If the pt. misses a dose within 18 hrs. of the time it is usual. taken, the pt. should take the drug with food as soon as possible and resume the normal dosing schedule. If a pt. misses a dose by more than 18 hrs., the pt. should not take the missed dose and simply resume the usual dosing schedule. If the pt. vomit. within 1 h of taking the drug another tab. should be taken.
Tmt. of adults & adolesc. (aged 12 yrs.& older with bdy. wt. at least 35 kg) and In child. aged 6 yrs. & older with bdy wt at least 25 kg for whom alternative regimens are unsuitable due to toxicities infect. with HIV 1 without any known mutations assoc. with resist. to the integrase inhib. class, emtricitabine or tenofovir.
C/I:  Hypersens. Co-admin. with: Alfuzosin, amiodarone, quinidine, dihydroergotamine, ergometrine, ergotamine, cisapride, lovastatin, simvastatin, lomitapide, pimozide, lurasidone, sildenafil for tmt. of pulmon. arter. Hypertens., midazolam, triazolam, carbamazepine, phenobarbital, phenytoin, rifampicin, St. John’s wort (Hyperic. perfora.), dabigatran.

Antiretrovirals. Elvitegravir 150 mg, Cobicistat 150 mg, Emtricitabine 200 mg, Tenofovir Disoproxil 245 mg.
TABS.:30. 1  tab. ×1/d with food. If the pt. misses a dose within 18 hrs. of the time it is usual. taken, the pt. should take the drug with food as soon as possible and resume the normal dosing schedule. If a pt. misses a dose by more than 18 hrs., the pt. should not take the missed dose and simply resume the usual dosing schedule. If the pt. vomit. within 1 h of taking the drug another tab. should be taken.
C/I: Hypersens. Pts. who have prev. discount.  tmt. with tenofovir disoproxil fumarate due to renal tox. , with/without reversal of the effects post-discont. Co-admin. with the follow. med. products due to the potent. for serious and/or life-threat.  events or loss of virologic response and possible resist. to this drug: α-1-adrenorecep. antagon.: alfuzosin -antiarrhythmics: amiodarone, quinidine Anticonvuls.: carbamazepine, phenobarbital, phenytoin , antimycobacterials: rifampicin, ergot derivatives: dihydroergotamine, ergometrine, ergotamine. GI motil.  agents: cisapride. Herb. products: St. John’s wort HMG Co-A reductase inhib.: lovastatin, simvastatin , neuroleptics: pimozide PDE-5 inhib. : sildenafil for tmt. of pulmon. arter. hypertens. Sedat./hypnotics: orally admin.  midazolam, triazolam.