Antiretrovirals

3 Drugs classified under this drug class

Antiretrovirals. Bictegravir 50 mg, Emtricitabine 200 mg, Tenofovir Alafenamide 25 mg.
F.C. TABS.: 30. 1 tab×1/d with/without
food. If the patient misses a dose
within 18 hours of the time it is
usually taken, the patient should take
the drug as soon as possible and
resume the normal dosing schedule.
If a patient misses a dose by more
than 18 hours, the patient should not
take the missed dose and simply
resume the usual dosing schedule.
If the patient vomits within 1 hour of
taking the drug another tablet should
be taken. If a patient vomits more
than 1 hour after taking the drug they
do not need to take another dose of
the drug until the next regularly
scheduled dose.
Treatment of adults infected with human
immunodeficiency virus-1 (HIV-1) without
present or past evidence of viral resistance
to the integrase inhibitor class,
emtricitabine or tenofovir.
C/I: Hypersens.
Co-admin. with rifampicin and St John’s
wort (Hypericum perforatum).

Antiretrovirals. Emtricitabine 200 mg, Elvitegravir 150 mg, Cobicistat 150 mg.
FILM COAT. TABS.:30.
Adult., paed. 6 yrs. and older, wt. at least 25 kg: 1 tab. ×1/d with food. If the pt. misses a dose within 18 hrs. of the time it is usual. taken, the pt. should take the drug with food as soon as possible and resume the normal dosing schedule. If a pt. misses a dose by more than 18 hrs., the pt. should not take the missed dose and simply resume the usual dosing schedule. If the pt. vomit. within 1 h of taking the drug another tab. should be taken.
Tmt. of adults & adolesc. (aged 12 yrs.& older with bdy. wt. at least 35 kg) and In child. aged 6 yrs. & older with bdy wt at least 25 kg for whom alternative regimens are unsuitable due to toxicities infect. with HIV 1 without any known mutations assoc. with resist. to the integrase inhib. class, emtricitabine or tenofovir.
C/I: Hypersens. Co-admin. α 1-adrenorecep. antag.: alfuzosin. antiarrhythmics: amiodarone, quinidine. Anticonvulsant.: carbamazepine, phenobarbital, phenytoin. antimycobacterials: rifampicin. Ergot derivate.: dihydroergotamine, ergometrine, ergotamine. GI motil. agents: cisapride. Herb. products: St. John’s wort (Hyperic.  perforat.). HMG Co-A reductase inhibit.: lovastatin, simvastatin. neuroleptics/antipsychotics: pimozide, lurasidone. PDE-5 inhibit.: sildenafil for the tmt. of pulmon. arter. hypertens. sedatives/hypnotics: orally admin. midazolam, triazolam.

Antiretrovirals. Elvitegravir 150 mg, Cobicistat 150 mg, Emtricitabine 200 mg, Tenofovir Disoproxil 245 mg.
TABS.:30. 1  tab. ×1/d with food. If the pt. misses a dose within 18 hrs. of the time it is usual. taken, the pt. should take the drug with food as soon as possible and resume the normal dosing schedule. If a pt. misses a dose by more than 18 hrs., the pt. should not take the missed dose and simply resume the usual dosing schedule. If the pt. vomit. within 1 h of taking the drug another tab. should be taken.
C/I: Hypersens. Pts. who have prev. discount.  tmt. with tenofovir disoproxil fumarate due to renal tox. , with/without reversal of the effects post-discont. Co-admin. with the follow. med. products due to the potent. for serious and/or life-threat.  events or loss of virologic response and possible resist. to this drug: α-1-adrenorecep. antagon.: alfuzosin -antiarrhythmics: amiodarone, quinidine Anticonvuls.: carbamazepine, phenobarbital, phenytoin , antimycobacterials: rifampicin, ergot derivatives: dihydroergotamine, ergometrine, ergotamine. GI motil.  agents: cisapride. Herb. products: St. John’s wort HMG Co-A reductase inhib.: lovastatin, simvastatin , neuroleptics: pimozide PDE-5 inhib. : sildenafil for tmt. of pulmon. arter. hypertens. Sedat./hypnotics: orally admin.  midazolam, triazolam.