All the Active Ingredient Drugs
Antiretrovirals. Emtricitabine 200 mg, Elvitegravir 150 mg, Cobicistat 150 mg. FILM COAT. TABS.:30.
Adult., paed. 6 yrs. and older, wt. at least 25 kg: 1 tab. ×1/d with food. If the pt. misses a dose within 18 hrs. of the time it is usual. taken, the pt. should take the drug with food as soon as possible and resume the normal dosing schedule. If a pt. misses a dose by more than 18 hrs., the pt. should not take the missed dose and simply resume the usual dosing schedule. If the pt. vomit. within 1 h of taking the drug another tab. should be taken.
Tmt. of adults & adolesc. (aged 12 yrs.& older with bdy. wt. at least 35 kg) and In child. aged 6 yrs. & older with bdy wt at least 25 kg for whom alternative regimens are unsuitable due to toxicities infect. with HIV 1 without any known mutations assoc. with resist. to the integrase inhib. class, emtricitabine or tenofovir.
C/I: Hypersens. Co-admin. with: Alfuzosin, amiodarone, quinidine, dihydroergotamine, ergometrine, ergotamine, cisapride, lovastatin, simvastatin, lomitapide, pimozide, lurasidone, sildenafil for tmt. of pulmon. arter. Hypertens., midazolam, triazolam, carbamazepine, phenobarbital, phenytoin, rifampicin, St. John’s wort (Hyperic. perfora.), dabigatran.
Antivirals for Treatment of HIV Infections. Darunavir 800 mg, Cobicistat 150 mg. F.C TABS: 30. Adults: 1 tab x 1 dly within 30 min. after food. Not indic. in childr.and adolesc. < 18 years and should not be used in pts < 3 years because of safety concerns.
Indications: In combinat. with other antiretrovir.agents for the tmt of HIV‑1 infect. in tmt-naïve and tmt-experienced adults with no darunavir resist.-associated substitutions (V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, L89V).
C/I: Hypersens. Pts.with sev.(Child Pugh Class C) hep. impairm. Co admin. with strong CYP3A inducers due to the potent. for loss of ther. effect: carbamazepine, phenobarbital, phenytoin, rifampicin, lopinavir/ritonavir, St John’s Wort, (Hypericum perforatum). Co admin. with following med. prod. due to the potent. for serious and/or life threat. adv. reactions: alfuzosin, amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine, astemizole, terfenadine, colchicine (in pts with renal and/or hepatic impairm.), rifampicin ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine), cisapride, dapoxetine, domperidone, naloxegol,lurasidone, pimozide, quetiapine, sertindole elbasvir/grazoprevir, triazolam, midazolam admin. orally, sildenafil when used for pulmon. arterial hypertension, avanafil, simvastatin, lovastatin and lomitapide, ticagrelor.
Antiretrovirals. Elvitegravir 150 mg, Cobicistat 150 mg, Emtricitabine 200 mg, Tenofovir Disoproxil 245 mg. TABS.:30. 1 tab. ×1/d with food. If the pt. misses a dose within 18 hrs. of the time it is usual. taken, the pt. should take the drug with food as soon as possible and resume the normal dosing schedule. If a pt. misses a dose by more than 18 hrs., the pt. should not take the missed dose and simply resume the usual dosing schedule. If the pt. vomit. within 1 h of taking the drug another tab. should be taken.
C/I: Hypersens. Pts. who have prev. discount. tmt. with tenofovir disoproxil fumarate due to renal tox. , with/without reversal of the effects post-discont. Co-admin. with the follow. med. products due to the potent. for serious and/or life-threat. events or loss of virologic response and possible resist. to this drug: α-1-adrenorecep. antagon.: alfuzosin -antiarrhythmics: amiodarone, quinidine Anticonvuls.: carbamazepine, phenobarbital, phenytoin , antimycobacterials: rifampicin, ergot derivatives: dihydroergotamine, ergometrine, ergotamine. GI motil. agents: cisapride. Herb. products: St. John’s wort HMG Co-A reductase inhib.: lovastatin, simvastatin , neuroleptics: pimozide PDE-5 inhib. : sildenafil for tmt. of pulmon. arter. hypertens. Sedat./hypnotics: orally admin. midazolam, triazolam.
