Darunavir

2 Drugs classified under this active ingredient

Protease Inhibitors. Darunavir 75, 150, 400, 600, 800 mg.
TABS: 480 x 75 mg ; 240 x 150 mg.
Tmt. HIV-1 infect. co-admin. with ritonavir
and with other antiretroviral agents in
adult pts and in tmt-experienc. pediatric
pts 6 yrs of age and older. See lit.
TABS: 60 x 400 mg, 60 x 600 mg, 30 x 800
mg.
Tmt. HIV-1 infect. in adult pts co-admin.
with ritonavir and with other antiretroviral
agents. See lit.
Tmt-naïve adults: 800 mg with 100 mg
ritonavir 1 x dly, with food. See lit.
Tmt-experience. adults: (With no
darunavir resist. assoc. subst.) 800 mg
with 100 mg ritonavir 1 x dly, with
food. See lit.
Tmt-experience. adults: (With at least 1
darunavir resist. assoc. substit.)
600 mg with 100 mg ritonavir 2 x dly,
with food. See lit.
C/I: Hypersens.; severe (Child-Pugh Class
C) hepatic impair.; Co-admin. with
ritonavir is C/I with drugs that are highly
dependent on CYP3A and drugs with
narrow therap. index.
Refer to ritonavir C/I. See lit.

Antivirals for Treatment of HIV Infections. Darunavir 800 mg, Cobicistat 150 mg.
F.C TABS: 30.  Adults: 1 tab x 1 dly within 30 min. after food. Not indic. in childr.and adolesc. < 18 years and should not be used in pts < 3 years because of safety concerns.
Indications: In combinat. with other antiretrovir.agents for the tmt of HIV‑1 infect. in tmt-naïve and tmt-experienced adults with no darunavir resist.-associated substitutions (V11I, V32I, L33F, I47V, I50V, I54L, I54M, T74P, L76V, I84V, L89V).
C/I: Hypersens. Pts.with sev.(Child Pugh Class C) hep. impairm. Co admin. with strong CYP3A inducers due to the potent. for loss of ther. effect: carbamazepine, phenobarbital, phenytoin, rifampicin, lopinavir/ritonavir, St John’s Wort, (Hypericum perforatum). Co admin. with following med. prod. due to the potent. for serious and/or life threat. adv. reactions: alfuzosin, amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine, astemizole, terfenadine, colchicine (in pts with renal and/or hepatic impairm.), rifampicin ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine), cisapride, dapoxetine, domperidone, naloxegol,lurasidone, pimozide, quetiapine, sertindole elbasvir/grazoprevir, triazolam, midazolam admin. orally, sildenafil   when used for pulmon. arterial hypertension, avanafil, simvastatin, lovastatin and lomitapide, ticagrelor.