All the Drug Class Drugs
Protease Inhibitors. Darunavir 800 mg. F.C. TABS.:30. 800 mg×1/d admin. every day at the same time, and always with 100 mg of ritonavir with food. See lit.
Indicated in co-admin.with 100 mg ritonavir and with other antiretrov. agents, for the tmt. of HIV-1infec. for pts. over 18 yrs. of age.
C/I: Hypersensitivity to active substance or to any of its excipients. Pts. under 18 yrs. old age. For pts. with hep. impair., addit. blood tests may be required.
Protease Inhibitors. Lopinavir 100 mg, 200 mg, 80 mg/ml, Ritonavir 25 mg, 50 mg, 20 mg/ml. F.C. TABS: 120 x lopinavir 200 mg/
ritonavir 50 mg ; 60 x lopinavir 100 mg/
ritonavir 25 mg.
ORAL SOL.: 5 x 60 ml x lopinavir 80 mg/
ritonavir 20 mg/ml.
Adult: 400 mg/100 mg (2 tabs of
200/50) 2 x dly with/out food; or 5 ml
soln. 2 x dly with food.
Child: 6 mths - 18 yrs: Calc. acc. To
weight: <15 kg: 12/3 mg/kg; >15-40 kg:
10/2.5 mg/kg, both 2 x dly. Calc. acc. To
BSA: See lit. Should not exceed
recommend. adult dose. Dosage
adjustment according to presc. info.
In comb. with other antiretroviral agents
for HIV - 1 infect.
C/I: Known hypersens.(e.g., toxic
epidermal necrolysis, Stevens-Johnson
syndr., erythema multiforme) or to any
of its ingred., include. ritonavir,
co-admin. with drugs highly depend. on
CYP3A for clearance, and for which
elevat. Plasma conc. assoc. with serious
and/or lifethreat. react. See lit.
Co-admin. with potent CYP3A inducers.
Protease Inhibitors. Glecaprevir 100 mg, Pibrentasvir 40 mg. F.C. TABS.:84. The recomm. dose is 300 mg/120 mg (3tabs.) ×1/d, with food. The recom. tmt. durat. for HCV genotype 1, 2, 3, 4, 5, or 6 infec. pts. with compens. liver dis. (with/ without cirrhos.): Recomm. tmt. durat. for pts. without prior HCV therap: All HCV genotyp. with NO cirrhos. – 8 wks., pts. with all HCV genotyp. WITH cirrhos. -12 wks. Recomm. tmt. durat. for pts. who failed prior ther.with peg-IFN + ribavirin +/- sofosbuvir, or sofosbuvir + ribavirin: Genotype 1, 2, 4-6 – with NO cirrhos. -8 wks., pts. WITH cirrhos.- 12 wks. Genotype GT 3- with/without cirrhos.-16 wks. See lit.
Tmt. of chron. hepat.C virus (HCV) infect. in adults.
C/I: Hypersens. Pts. with sev. hep. impair. (Child-Pugh C). Concom. use with atazanavir contain. product., atorvastatin, simvastatin, dabigatran etexilate, ethinyl oestradiol-contain. product. , strong P-gp and CYP3A induc.(e.g., rifampicin, carbamazepine, St. John’s wort (Hypericum perforatum), phenobarbital, phenytoin, and primidone). Special precautions, Drug interactions, Side effects: See prescribing information for full details.
Protease Inhibitors. Ritonavir 100 mg. F.C. TABS: 30, 60 x 100 mg.
Monother., adults: 600 mg 2 x dly
with food. Child. over 2 yrs: 350
mg/m2 x dly, max 600 mg 2 x dly. Combined with other PIs as
pharmacokinet. enhanc. – see lit.
Alone/in comb. with other
antiretroviral agents for tmt. HIV infect.
C/I: Hypesens., pts. with decompens.
liver dis. Meds. that metabol. by CYP3A,CYP2D6,-see lit.
Protease Inhibitors. Darunavir 75, 150, 400, 600, 800 mg. TABS: 480 x 75 mg ; 240 x 150 mg.
Tmt. HIV-1 infect. co-admin. with ritonavir
and with other antiretroviral agents in
adult pts and in tmt-experienc. pediatric
pts 6 yrs of age and older. See lit.
TABS: 60 x 400 mg, 60 x 600 mg, 30 x 800
Tmt. HIV-1 infect. in adult pts co-admin.
with ritonavir and with other antiretroviral
agents. See lit.
Tmt-naïve adults: 800 mg with 100 mg
ritonavir 1 x dly, with food. See lit.
Tmt-experience. adults: (With no
darunavir resist. assoc. subst.) 800 mg
with 100 mg ritonavir 1 x dly, with
food. See lit.
Tmt-experience. adults: (With at least 1
darunavir resist. assoc. substit.)
600 mg with 100 mg ritonavir 2 x dly,
with food. See lit.
C/I: Hypersens.; severe (Child-Pugh Class
C) hepatic impair.; Co-admin. with
ritonavir is C/I with drugs that are highly
dependent on CYP3A and drugs with
narrow therap. index.
Refer to ritonavir C/I. See lit.
Protease Inhibitors. Atazanavir (as sulfate) 150, 200, 300 mg. CAPS: 60 x 150 mg, 200 mg, 30 x
300 mg. Adults (18 yrs and above): Tmtnaive
pts, 1 x dly with food: 300 mg
with ritonavir, or 300 mg comb. with
tenofovir and ritonavir, or 400 mg for
pts unable to tolerate ritonavir, or 400
mg when comb. with efavirenz and
ritonavir. Ther. experienced pts, 1 x dly
with food: 300 mg with ritonavir, or
400 mg comb. with tenofovir and
ritonavir. Child 6 yrs and above: See lit.
In comb. with other antiretrovir. agents
for tmt HIV-1 infect.