• Home
  • A-B index
  • Pharmacological Index
  • Drug Classes
  • Active Ingredients
  • Companies
  • News
  • Protease Inhibitors
    5 Drugs classified under this drug class


    All the Drug Class Drugs

    Kaletra
    AbbVie
    RX
    partial basket chart
    Multiple ingredients
    Kaletra

    Protease Inhibitors. Lopinavir 100 mg, 200 mg, 80 mg/ml, Ritonavir 25 mg, 50 mg, 20 mg/ml.
    F.C. TABS: 120 x lopinavir 200 mg/
    ritonavir 50 mg ; 60 x lopinavir 100 mg/
    ritonavir 25 mg.
    ORAL SOL.: 5 x 60 ml x lopinavir 80 mg/
    ritonavir 20 mg/ml.
    Adult: 400 mg/100 mg (2 tabs of
    200/50) 2 x dly with/out food; or 5 ml
    soln. 2 x dly with food.
    Child: 6 mths - 18 yrs: Calc. acc. To
    weight: <15 kg: 12/3 mg/kg; >15-40 kg:
    10/2.5 mg/kg, both 2 x dly. Calc. acc. To
    BSA: See lit. Should not exceed
    recommend. adult dose. Dosage
    adjustment according to presc. info.
    In comb. with other antiretroviral agents
    for HIV - 1 infect.
    C/I: Known hypersens.(e.g., toxic
    epidermal necrolysis, Stevens-Johnson
    syndr., erythema multiforme) or to any
    of its ingred., include. ritonavir,
    co-admin. with drugs highly depend. on
    CYP3A for clearance, and for which
    elevat. Plasma conc. assoc. with serious
    and/or lifethreat. react. See lit.
    Co-admin. with potent CYP3A inducers.

    Maviret
    AbbVie
    RX
    partial basket chart
    Multiple ingredients
    Maviret

    Protease Inhibitors. Glecaprevir 100 mg, Pibrentasvir 40 mg.
    F.C. TABS.:84.  The recomm. dose is 300 mg/120 mg (3tabs.) ×1/d, with food. The recom.  tmt. durat. for HCV genotype 1, 2, 3, 4, 5, or 6 infec. pts. with compens. liver dis. (with/ without cirrhos.): Recomm.  tmt. durat. for pts. without prior HCV therap: All HCV genotyp. with NO cirrhos. – 8 wks., pts. with all  HCV genotyp. WITH  cirrhos. -12 wks. Recomm. tmt. durat. for pts. who failed prior ther.with peg-IFN + ribavirin +/- sofosbuvir, or sofosbuvir + ribavirin:  Genotype 1, 2, 4-6 – with NO cirrhos. -8 wks., pts. WITH  cirrhos.- 12 wks. Genotype GT 3- with/without cirrhos.-16 wks. See lit.
    Tmt. of chron. hepat.C virus (HCV) infect. in adults.
    C/I: Hypersens. Pts.  with sev. hep. impair. (Child-Pugh C). Concom. use with atazanavir contain. product., atorvastatin, simvastatin, dabigatran etexilate, ethinyl oestradiol-contain. product. , strong P-gp and CYP3A induc.(e.g., rifampicin, carbamazepine, St. John’s wort (Hypericum perforatum), phenobarbital, phenytoin, and primidone). Special precautions, Drug interactions, Side effects: See prescribing information for full details.

    Norvir
    AbbVie
    RX
    partial basket chart
    Norvir

    Protease Inhibitors. Ritonavir 100 mg.
    F.C. TABS: 30, 60 x 100 mg.
    Monother., adults: 600 mg 2 x dly
    with food. Child. over 2 yrs: 350
    mg/m2 x dly, max 600 mg 2 x dly. Combined with other PIs as
    pharmacokinet. enhanc. – see lit.
    Alone/in comb. with other
    antiretroviral agents for tmt. HIV infect.
    C/I: Hypesens., pts. with decompens.
    liver dis. Meds. that metabol. by CYP3A,CYP2D6,-see lit.

    Prezista
    Janssen
    RX
    partial basket chart
    Prezista

    Protease Inhibitors. Darunavir 75, 150, 400, 600, 800 mg.
    TABS: 480 x 75 mg ; 240 x 150 mg.
    Tmt. HIV-1 infect. co-admin. with ritonavir
    and with other antiretroviral agents in
    adult pts and in tmt-experienc. pediatric
    pts 6 yrs of age and older. See lit.
    TABS: 60 x 400 mg, 60 x 600 mg, 30 x 800
    mg.
    Tmt. HIV-1 infect. in adult pts co-admin.
    with ritonavir and with other antiretroviral
    agents. See lit.
    Tmt-naïve adults: 800 mg with 100 mg
    ritonavir 1 x dly, with food. See lit.
    Tmt-experience. adults: (With no
    darunavir resist. assoc. subst.) 800 mg
    with 100 mg ritonavir 1 x dly, with
    food. See lit.
    Tmt-experience. adults: (With at least 1
    darunavir resist. assoc. substit.)
    600 mg with 100 mg ritonavir 2 x dly,
    with food. See lit.
    C/I: Hypersens.; severe (Child-Pugh Class
    C) hepatic impair.; Co-admin. with
    ritonavir is C/I with drugs that are highly
    dependent on CYP3A and drugs with
    narrow therap. index.
    Refer to ritonavir C/I. See lit.

    Reyataz
    BMS
    RX
    partial basket chart
    Reyataz

    Protease Inhibitors. Atazanavir (as sulfate) 150, 200, 300 mg.
    CAPS: 60 x 150 mg, 200 mg, 30 x
    300 mg. Adults (18 yrs and above): Tmtnaive
    pts, 1 x dly with food: 300 mg
    with ritonavir, or 300 mg comb. with
    tenofovir and ritonavir, or 400 mg for
    pts unable to tolerate ritonavir, or 400
    mg when comb. with efavirenz and
    ritonavir. Ther. experienced pts, 1 x dly
    with food: 300 mg with ritonavir, or
    400 mg comb. with tenofovir and
    ritonavir. Child 6 yrs and above: See lit.
    In comb. with other antiretrovir. agents
    for tmt HIV-1 infect.

    CLOSE