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  • Protease Inhibitors
    5 Drugs classified under this drug class


    All the Drug Class Drugs

    Darunavir Teva
    Teva
    RX
    partial basket chart
    Darunavir Teva

    Protease Inhibitors. Darunavir 800 mg.
    F.C. TABS.:30. 800 mg×1/d admin. every day at the same time, and always with 100 mg of ritonavir with food. See lit.
    Indicated in co-admin.with 100 mg ritonavir and with other antiretrov. agents, for the tmt. of HIV-1infec. for pts. over 18 yrs. of age.
    C/I: Hypersensitivity to active substance or to any of its excipients. Pts. under 18 yrs. old age. For pts. with hep. impair., addit. blood tests may be required.

    Kaletra
    AbbVie
    RX
    partial basket chart
    Multiple ingredients
    Kaletra

    Protease Inhibitors. Lopinavir 100 mg, 200 mg, 80 mg/ml, Ritonavir 25 mg, 50 mg, 20 mg/ml.
    F.C. TABS: 120 x 200 / 50 mg; 60 x 100 / 25 mg.
    ORAL SOL.: 60 ml x 80 / 20 mg/ml.
    Adult: 400 mg/100 mg (2 tabs of 200/50) 2 x dly with/out food; or 5 ml soln. 2 x dly with food.
    Child: 6 mths-18 yrs: Calc. acc. to 
    weight: <15 kg: 12/3 mg/kg; >15-40 kg: 10/2.5 mg/kg, both 2 x dly. Calc. acc. to BSA: See lit. Should not exceed recommend. adult dose. Dosage adjustment according to presc. info.
    In comb. with other antiretroviral agents for HIV-1 infect.
    C/I: Pts. with prev. demonstrat. clinical.  signific. hypersens. (e.g., toxic epiderm. necrolysis, Stevens-Johnson syndr., erythema multiforme, urticaria, angioedema) to any of its ingred., includ. ritonavir. Concom. use with drugs that are highly dependent on CYP3A for clear. and for which elevated plasma conc. are assoc. with serious and/or life-threat. react. (e.g. alfuzosin, ranolazine, dronedarone, colchicine, lurasidone, pimozide dihydroergotamine, ergotamine, methylergonovine, cisapride, elbasvir/grazoprevir, lovastatin, simvastatin, lomitapide, sildenafil -when used for the tmt. of pulm. arterial hyperten., triazolam, oral. admin. midazolam).
    Concom. use with drugs that are potent CYP3A induc. where signific. reduced lopinavir plasma conc. may be assoc. with the potential for loss of virologic response and possible resistance and cross-resist. (e.g. Rifampin, St. John's Wort -hypericum perfor.) See lit.

    Maviret
    AbbVie
    RX
    partial basket chart
    Multiple ingredients
    Maviret

    Protease Inhibitors. Glecaprevir 100 mg, Pibrentasvir 40 mg.
    F.C. TABS.:84.  The recomm. dose is 300 mg/120 mg (3tabs.) ×1/d, with food. The recom.  tmt. durat. for HCV genotype 1, 2, 3, 4, 5, or 6 infec. pts. with compens. liver dis. (with/ without cirrhos.): Recomm.  tmt. durat. for pts. without prior HCV therap: All HCV genotyp. with NO cirrhos. – 8 wks., pts. with all  HCV genotyp. WITH  cirrhos. -12 wks. Recomm. tmt. durat. for pts. who failed prior ther.with peg-IFN + ribavirin +/- sofosbuvir, or sofosbuvir + ribavirin:  Genotype 1, 2, 4-6 – with NO cirrhos. -8 wks., pts. WITH  cirrhos.- 12 wks. Genotype GT 3- with/without cirrhos.-16 wks. See lit.
    Tmt. of chron. hepat.C virus (HCV) infect. in adults.
    C/I: Hypersens. Pts.  with sev. hep. impair. (Child-Pugh C). Concom. use with atazanavir contain. product., atorvastatin, simvastatin, dabigatran etexilate, ethinyl oestradiol-contain. product. , strong P-gp and CYP3A induc.(e.g., rifampicin, carbamazepine, St. John’s wort (Hypericum perforatum), phenobarbital, phenytoin, and primidone). Special precautions, Drug interactions, Side effects: See prescribing information for full details.

    Norvir
    AbbVie
    RX
    partial basket chart
    Norvir

    Protease Inhibitors. Ritonavir 100 mg.
    F.C. TABS: 30, 60 x 100 mg.
    Monother., adults: 600 mg 2 x dly
    with food. Child. over 2 yrs: 350
    mg/m² x dly, max 600 mg 2 x dly. Combined with other PIs as
    pharmacokinet. enhanc. See lit.
    Alone/in comb. with other antiretroviral agents for tmt. HIV infect.
    C/I: Hypesens., pts. with decompens.
    liver dis. Meds. that metabol. by CYP3A,CYP2D6. See lit.

    Prezista
    Janssen
    RX
    partial basket chart
    Prezista

    Protease Inhibitors. Darunavir 75, 150, 400, 600, 800 mg.
    TABS: 480 x 75 mg ; 240 x 150 mg.
    Tmt. HIV-1 infect. co-admin. with ritonavir
    and with other antiretroviral agents in
    adult pts and in tmt-experienc. pediatric
    pts 6 yrs of age and older. See lit.
    TABS: 60 x 400 mg, 60 x 600 mg, 30 x 800
    mg.
    Tmt. HIV-1 infect. in adult pts co-admin.
    with ritonavir and with other antiretroviral
    agents. See lit.
    Tmt-naïve adults: 800 mg with 100 mg
    ritonavir 1 x dly, with food. See lit.
    Tmt-experience. adults: (With no
    darunavir resist. assoc. subst.) 800 mg
    with 100 mg ritonavir 1 x dly, with
    food. See lit.
    Tmt-experience. adults: (With at least 1
    darunavir resist. assoc. substit.)
    600 mg with 100 mg ritonavir 2 x dly,
    with food. See lit.
    C/I: Hypersens.; severe (Child-Pugh Class
    C) hepatic impair.; Co-admin. with
    ritonavir is C/I with drugs that are highly
    dependent on CYP3A and drugs with
    narrow therap. index.
    Refer to ritonavir C/I. See lit.

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