All the Active Ingredient Drugs
Protease Inhibitors. Lopinavir 100 mg, 200 mg, 80 mg/ml, Ritonavir 25 mg, 50 mg, 20 mg/ml. F.C. TABS: 120 x 200 / 50 mg; 60 x 100 / 25 mg.
ORAL SOL.: 60 ml x 80 / 20 mg/ml.
Adult: 400 mg/100 mg (2 tabs of 200/50) 2 x dly with/out food; or 5 ml soln. 2 x dly with food.
Child: 6 mths-18 yrs: Calc. acc. to weight: <15 kg: 12/3 mg/kg; >15-40 kg: 10/2.5 mg/kg, both 2 x dly. Calc. acc. to BSA: See lit. Should not exceed recommend. adult dose. Dosage adjustment according to presc. info.
In comb. with other antiretroviral agents for HIV-1 infect.
C/I: Pts. with prev. demonstrat. clinical. signific. hypersens. (e.g., toxic epiderm. necrolysis, Stevens-Johnson syndr., erythema multiforme, urticaria, angioedema) to any of its ingred., includ. ritonavir. Concom. use with drugs that are highly dependent on CYP3A for clear. and for which elevated plasma conc. are assoc. with serious and/or life-threat. react. (e.g. alfuzosin, ranolazine, dronedarone, colchicine, lurasidone, pimozide dihydroergotamine, ergotamine, methylergonovine, cisapride, elbasvir/grazoprevir, lovastatin, simvastatin, lomitapide, sildenafil -when used for the tmt. of pulm. arterial hyperten., triazolam, oral. admin. midazolam).
Concom. use with drugs that are potent CYP3A induc. where signific. reduced lopinavir plasma conc. may be assoc. with the potential for loss of virologic response and possible resistance and cross-resist. (e.g. Rifampin, St. John's Wort -hypericum perfor.) See lit.
Protease Inhibitors. Ritonavir 100 mg. F.C. TABS: 30, 60 x 100 mg.
Monother., adults: 600 mg 2 x dly
with food. Child. over 2 yrs: 350
mg/m² x dly, max 600 mg 2 x dly. Combined with other PIs as
pharmacokinet. enhanc. See lit.
Alone/in comb. with other antiretroviral agents for tmt. HIV infect.
C/I: Hypesens., pts. with decompens.
liver dis. Meds. that metabol. by CYP3A,CYP2D6. See lit.