All the Therapeutic System Drugs
Selective Norepinephrine Reuptake Inhibitor. Atomoxetine (as HCl) 18, 25, 40, 60, 80, 100 mg. F.C. Tabs: 28 X 18, 25, 40, 60, 100 mg. Paed. pts. up to 70 kg bdy. wt.: Initial. at a tot. dly dose of approx. 0.5 mg/kg. Ini dose should be mainten. for a min. of 7 d. prior to upward dose titrat. accord. to clinical response and tolerab. The recommen. mainten. dose is approx. 1.2 mg/kg/d. (depend. on the pt’s. wt. and available dosage strengths of atomoxetine).Paed. pts. over 70 kg bdy. wt. and adult.: Ini. at a tot. dly. dose of 40 mg. Ini. dose should be maintain. for a min. of 7 d. prior to upward dose titrat. accord. to clinical response and tolerab. Recomm. mainten. dose is 80 mg. max. recom. total dly. dose is 100 mg.
Indic. for the tmt. of ADHD in child. of 6 yrs. and older, in adolesc. & in adult. as part of a comprehensive tmt. programme. Tmt. must be initi. by a special. in the tmt. of ADHD, such as a paediatrician, child/adolesc. psychiatrist, or psychiatrist. Diagnos. should be made accord. to current DSM criteria or the guidelines in ICD. In adult., the presence of sympt. of ADHD that were pre-exist. in childhood should be confirmed. Third-party corroboration is desirable and the drug should not be initi. when the verifi. of childhood ADHD sympt. is uncertain. Diagnos. cannot be made solely on the presence of one or more sympt. of ADHD. Based on clinic. Judgm., pts. should have ADHD of at least moder. severity as indica. by at least mod. function. impair. in 2 or more settings (for example, social, academic, and/or occupational funct.), affect. several aspects of an individual’s life.
C/I: Hypersens. Comb. with MAOI. should not be used within a min. of 14 d. after discont. ther. with MAOI. Tmt. with MAOI should not be init. within 14 d. after discont. atomoxetine.
Pts. with narrow-ang. glauc.
Pts. with pheochromocytom.
Pts. with severe card./vascular disord., hypertens., tachycard.
Amphetamines. Dextroamphetamine Saccharate 1.25, 2.5, 5, 7.5 mg, Amphetamine Aspartate Monohydrate 1.25, 2.5, 5, 7.5 mg, Dextroamphetamine Sulfate 1.25, 2.5, 5, 7.5 mg, Amphetamine Sulfate 1.25, 2.5, 5, 7.5 mg. TABS.: 100× 5, 10, 20, 30 mg. Not recom.
for child. under 3 yrs. of age. Child. 6
yrs. of age and older, start with 5 mg
once/twice dly.; daily dosage may be
inc. in increments of 5 mg at wkly.
intervals until optim. response is
obtained. Narcolepsy: Usual dose 5 mg
- 60 mg per day in divided doses,
depend. on the individ. pt. response.
Tmt. of ADHD and Narcolepsy.
C/I: Hypertens., hyperthyroid., known
hypersens./ idiosyncrasy to the
sympathomim. amines. Glaucoma.
Agitated states. Pts. with a hist.of drug
abuse. During or within 14 days follow.
the adminis. of MAO’s inhib. (hyperten.
crises may result). Advanced
arteriosclerosis, symptom. cardiovasc.
dis., moder.- sev.
Amphetamines. Dextroamphetamine Sulfate 1.25, 2.5, 5, 7.5 mg, Dextroamphetamine Saccharate 1.25, 2.5, 5, 7.5 mg, Amphetamine Sulfate 1.25, 2.5, 5, 7.5 mg, Amphetamine Aspartate Monohydrate 1.25, 2.5, 5, 7.5 mg. EXT. REL. CAPS.:10/20/30 mg X30. Indiv. dosage at the lowest effect. dose.
Childr.: 6 to 12 years of age: start with 10 mg once daily in the morn.; daily dosage may be adj. in incr. of 5 mg or 10 mg at wkly intervals. Also, pts. may begin with 5 mg once daily in the morn. Max recom. dose for childr. 6 to 12 years of age is 30 mg/day; Adolesc.: Start. dose for adolesc. who are 13 to 17 years of age is 10 mg/day. Dose may be incr. to 20 mg/day after one week if needed. Adlts: recom. dose is 20 mg/day. See prescr. info. for further details.
Attent. deficit hyperact. disor. (ADHD).
C/I: * Adv. arterioscl.*Symptom. cardiovas. dis.
* Moder. to sev. hyperten.* Hyperthyr.
* Glaucoma.* Agitated states.
* Hist. of drug abuse.
* Pts. taking MAOIs, or within 14 days of stopping MAOIs (including linezolid or IV methylene blue), bec. of incr. risk of hyperten. crisis.
*Hypersens.
CNS Stimulant. Methylphenidate HCl 18, 27, 36, 54 mg. E.R. TABS: 30 x 18 mg, 27 mg, 36 mg, 54
mg. Initial: 18 mg 1 x dly in the morn.
May adjust in increments of 18 mg to
max 54 mg dly, at approx. wkly
intervals. Pts. new to methylphenidate
or who are on other stimulants: 18 mg
1 x dly. Pts. currently taking 5 mg
methylphenidate 2 x dly or 3 x dly: 18
mg. Pts. currently taking 10 mg 2 x dly
or 3 x dly: 36 mg. Some cases: 54 mg.
Max. dly dose: 54 mg.
Tmt. attent. deficit hyperact. disord.
(ADHD).
Psychostimulant. Armodafinil 50, 150, 250 mg. TABS.: 7, 28, 30, 60.
Narcolepsy, sleep disord. due to OSA: 150-250 mg×1/d, in the morn.
Sleep disord. due to working in shifts: 150 mg×1/d, about 1 hour before start. the shift.
Armodafinil is indicat. to improve wakefulness in adult pts. with excessive sleepiness assoc. with obstruct. sleep apnea (OSA), narcolepsy, or shift work disorder (SWD).
C/I: Hypersens. Hypersens. to Provigil or Modafinil.
Psychostimulant. Modafinil 100 mg. CAPLET.: 10, 30, 60, 90. init. reccomen. dly. dose is 200 mg. The total dly. dose may be taken as a single dose in the morn. or as two doses, one in the morn. and one at noon. Doses of up to 400mg in one or two divid. doses can be used in pts. with insufficient response to the initial 200mg modafinil dose. See Lit.
Improves wakefulness in pts. with excessive sleepiness assoc. with narcolepsy (with or without cataplexy), obstruct. sleep apnea/hypopnea syndr. (OSAHS) and shift work sleep disord. (SWDS).
C/I: Hypersens. Uncontrol., moder. to sev. hypertens. and in pts. with card. arrhythm.
