All the Therapeutic System Drugs
Selective Norepinephrine Reuptake Inhibitor. Atomoxetine (as HCl) 25, 40, 60 mg. F.C. TABS.: 28×25, 40, 60mg. Paed. pts. up to 70 kg bdy. wt.: Initial. at a total dly dose of approx. 0.5 mg/kg. The initial dose should be maintain. for a min. of 7 d. prior to upward dose titrat. accord. to clinical response and tolerab. The recommended mainten. dose is approx. 1.2 mg/kg/d. (depend. on the pt’s. wt. and available dosage strengths of atomoxetine).
Dosing of paed. pts. over 70 kg bdy. wt. and Adult.: The Drug should be initiated at a total daily dose of 40 mg. The initial dose should be maintain. for a min. of 7 d. prior to upward dose titrat. accord. to clinical response and tolerab.. The recomm. mainten. dose is 80mg. The max. recom. total dly. dose is 100 mg.
Indicated for the tmt. of ADHD in child. of 6 yrs. and older, in adolesc. & in adult. as part of a comprehensive tmt. programme. Tmt. must be initiated by a specialist in the tmt. of ADHD, such as a paediatrician, child/adolesc. psychiatrist, or psychiatrist. Diagnosis should be made accord. to current DSM criteria or the guidelines in ICD. In adult., the presence of sympt. of ADHD that were pre-exist. in childhood should be confirmed. Third-party corroboration is desirable and the drug should not be initiated when the verification of childhood ADHD sympt. is uncertain. Diagnosis cannot be made solely on the presence of one or more sympt. of ADHD. Based on clinical judgment, pts. should have ADHD of at least moder. severity as indicated by at least moderate function. impair. in 2 or more settings (for example, social, academic, and/or occupational functioning), affecting several aspects of an individual’s life.
C/I: Hypersens. Comb. with MAOI. Atomoxetine should not be used within a min. of 14 d. after discont. ther. with MAOI. Tmt. with MAOI should not be init. within 14 d. after discont. atomoxetine.
Pts. with narrow-ang. glauc.
Pts. with pheochromocytom.
Pts. with severe card./vascular disord., hypertens., tachycard.
Amphetamines. Dextroamphetamine Saccharate 1.25, 2.5, 5, 7.5 mg, Amphetamine Aspartate Monohydrate 1.25, 2.5, 5, 7.5 mg, Dextroamphetamine Sulfate 1.25, 2.5, 5, 7.5 mg, Amphetamine Sulfate 1.25, 2.5, 5, 7.5 mg. TABS.: 100× 5, 10, 20, 30 mg. Not recom.
for child. under 3 yrs. of age. Child. 6
yrs. of age and older, start with 5 mg
once/twice dly.; daily dosage may be
inc. in increments of 5 mg at wkly.
intervals until optim. response is
obtained. Narcolepsy: Usual dose 5 mg
- 60 mg per day in divided doses,
depend. on the individ. pt. response.
Tmt. of ADHD and Narcolepsy.
C/I: Hypertens., hyperthyroid., known
hypersens./ idiosyncrasy to the
sympathomim. amines. Glaucoma.
Agitated states. Pts. with a hist.of drug
abuse. During or within 14 days follow.
the adminis. of MAO’s inhib. (hyperten.
crises may result). Advanced
arteriosclerosis, symptom. cardiovasc.
dis., moder.- sev.
CNS Stimulant. Methylphenidate HCl 18, 27, 36, 54 mg. E.R. TABS: 30 x 18 mg, 27 mg, 36 mg, 54
mg. Initial: 18 mg 1 x dly in the morn.
May adjust in increments of 18 mg to
max 54 mg dly, at approx. wkly
intervals. Pts. new to methylphenidate
or who are on other stimulants: 18 mg
1 x dly. Pts. currently taking 5 mg
methylphenidate 2 x dly or 3 x dly: 18
mg. Pts. currently taking 10 mg 2 x dly
or 3 x dly: 36 mg. Some cases: 54 mg.
Max. dly dose: 54 mg.
Tmt. attent. deficit hyperact. disord.
Psychostimulant. Armodafinil 50, 150, 250 mg. TABS.: 7, 28, 30, 60.
Narcolepsy, sleep disord. due to OSA: 150- 250 mg×1/d, in the morn. Sleep disord. due to working in shifts: 150 mg×1/d, about 1 hour before start.the shift.
Armodafinil is indicat. to improve wakefulness in adult pts. with excessive sleepiness assoc. with obstruct. sleep apnea (OSA), narcolepsy, or shift work disorder (SWD).
C/I: Hypersens. Hypersens. to Provigil or Modafinil.
Psychostimulant. Modafinil 100 mg. CAPLET.: 10, 30, 60, 90. init. reccomen. dly. dose is 200 mg. The total dly. dose may be taken as a single dose in the morn. or as two doses, one in the morn. and one at noon. Doses of up to 400mg in one or two divid. doses can be used in pts. with insufficient response to the initial 200mg modafinil dose. See Lit.
Improves wakefulness in pts. with excessive sleepiness assoc. with narcolepsy (with or without cataplexy), obstruct. sleep apnea/hypopnea syndr. (OSAHS) and shift work sleep disord. (SWDS).
C/I: Hypersens. Uncontrol., moder. to sev. hypertens. and in pts. with card. arrhythm.