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  • Alzheimer's Disease
    14 Drugs classified under this therapeutic system


    All the Therapeutic System Drugs

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    Asenta
    Perrigo
    RX
    partial basket chart
    Asenta

    Acetylcholinesterase Inhibitor. Donepezil HCl 5 mg, 10 mg.
    F.C. TABS: 28. 1 x 5 mg or 10 mg tab 1 x
    dly.
    Mild to mod. dementia of Alzheimer’s
    type.
    C/I: Hypersens. to donepezil HCl or to
    piperadine derivatives.

    Donepezil Teva 5 mg, 10 mg
    Teva
    RX
    partial basket chart
    Donepezil Teva 5 mg, 10 mg

    Acetylcholinesterase Inhibitor. Donepezil HCl 5 mg, 10 mg.
    TABS.: 30. General., as a start. dosage 5 mg ×1/d at night before bed time. After one month, the dose may be incr. to 10 mg. The max. recomm. dosage is 10 mg each night. The tablet cannot be halved, as there is no score line.
    Tmt. of mild- moder.  severe Alzheimer's dementia.
    C/I: Hypersens. to active  subst., piperidine derivat.

    Ebixa 10 mg
    Lundbeck
    RX
    not in the basket chart
    Ebixa 10 mg

    NMDA Antagonist. Memantine HCl 10 mg.
    TABS: 56. Max: 20 mg dly. Titrat. for
    maint. dose by 5 mg/wk for first 3 wks:
    1st wk: 5 mg dly (1/2 tab); 2nd wk: mg
    1 x dly; 3rd wk: 15 mg 1 x dly.; 4th
    wk: Cont. with maint. dose: 20 mg 1 x
    dly. See lit.
    Tmt. of pts. with moder.- sev. Alzheimer’s
    dis.
    C/I: Hypersens.

    Ebixa 20 mg
    Lundbeck
    RX
    not in the basket chart
    Ebixa 20 mg

    NMDA Antagonist. Memantine HCl 20 mg.
    TABS: 28, 56. Max: 20 mg dly. Titrat. for
    maint. dose by 5 mg/wk for first 3 wks:
    1st wk: 5 mg dly (1/2 tab); 2nd wk: mg
    1 x dly; 3rd wk: 15 mg 1 x dly.; 4th
    wk: Cont. with maint. dose: 20 mg 1 x
    dly. See lit.
    Tmt. of pts. with moder.- sev. Alzheimer’s
    dis.
    C/I: Hypersens.

    Ebixa Oral Drops
    Lundbeck
    RX
    not in the basket chart
    Ebixa Oral Drops

    NMDA Antagonist. Memantine HCl 10 mg/g.
    ORAL SOL.: 50 g x 5 mg pump
    actuation. Recommend. maint. dose:
    20 mg (4 pump actuats.) dly achieved
    by upward titrat. of 5 mg/wk over 1st 3
    wks as follows: 1st wk: 1 pump actuat.
    1 x dly, 2nd wk: 2 pump actuats. 1 x
    dly; 3rd wk: 3 pump actuats. 1 x dly;
    4th week on: Max 4 pump actuats. 1 x
    dly. Not recommend. child under 18
    yrs. See lit.
    Tmt. of pts. with moder.- sev. Alzheimer’s
    dis.
    C/I: Hypersens.

    Exelon
    Novartis
    RX
    partial basket chart
    Exelon

    Acetylcholinesterase Inhibitor. Rivastigmine 1.5, 3, 4.5 , 6 mg.
    CAPS: 28 x 1.5, 3, 4.5.
    Initi. dose: 1.5 mg ×2/d., Pts. known to
    be particul. sensit. to the effects of cholinerg. drugs should be start. at a dose of 1 mg ×2/d. Dose titrat. Init.: 1.5 mg×2/d. If this dose is well toler. after a minim. of 2 wks. of tmt., the dose may be incr. to 3 mg×2/d. Subseq. incr. to 4.5 mg and then 6 mg ×2/d based on good tolerab.  of the current dose and may
    be consid. after a minim. of 2 wks. tmt.
    at that dose level.
    If adverse effects (e.g. naus., vomit.,
    abd. pain, loss of appetite) wt. decr. are
    observ. during tmt., these may
    respond to omit. one or more doses. If
    ADR effects persist, the dly. dose
    should be reduced to the previous
    well-tolerat. dose.
    Re-init. of therapy: If tmt. is interrupt.
    for longer than 3 d, tmt. should be
    re-init. with 1.5 mg ×2/d and titrat. as
    described above.
    Mainten. dose: 1.5 mg -6 mg ×2/d; to
    achieve max. therap. benefit pts. should
    be maintain. on their highest well tolerated dose.
    Recommend. max. dly. dose 6 mg ×2/a
    Caps. should be admin. with morn.and even. meals.
    Tmt. of pts. with mild – moder. sev. dement.
    of the alzheimer type, also termed probable
    alzheimer’s dis. or alzheimer’s dis. Symptom. tmt. of mild to moder. sev. alzheimer’s dement. Symptom. tmt. of mild – moder. sev. dementia assoc. with Parkinson’s dis.
    C/I: Known hypersens. to rivastigmine,
    to other carbamate derivat.
    Prev. history of applicat. site react.
    suggest. of allerg. contact dermatit. with
    rivastigmine transderm. patch.


    Other therapeutic systems under Central Nervous System

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