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  • Anticonvulsants
    30 Drugs classified under this therapeutic system

    All the Therapeutic System Drugs

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    Axiban Sublingual Drops IMC-Medical Grade Cannabis Oil
    not in the basket chart
    Multiple ingredients
    Axiban Sublingual Drops IMC-Medical Grade Cannabis Oil

    Cannabinoids. THC 0.3, 0.9, 1.5, 3, 4.5 mg/drop, CBD 0.6, 0.9, 3, 4.5, 6 mg/drop.
    *This product requires a license for medical cannabis.
    BOTTLE. (sublingual drop.): 10gr (330 drops). Dosage should be adjust. individual.
    The Israel MOH has outlined in Guidance 106 the 12 indicat. for which med. cannabis is indicated. Accord. to this guidance, the 11 indicat. for this product are:
    Chemother-induc. nausea and vomit. (CINV)/ chemother induc. pain.
    Metastat. cancer pain.
    Neuropath. pain.
    Spastic. of MS.
    Pain in Parkinson's dis.
    Cachexia in AIDS.
    Tourette's syndr.
    Recalcitrant epilep. in adult. (Note: Accord. to Guidance 106, med. cannab. is also indic. for recalcitrant epilep. in ped. pts. but this is not an indicat. for this product)
    Palliative care for termin. ill pts.
    Post- traum. stress disord.
    In general, the use of med. cannabis is indicated in pts. who have adequate. tried and failed convent. ther.
    Please refer to Guidance 106 for details.
    In addition, for an individ. pt. with a clinical. signific. med. condit. that cannot be adequate. managed by convent. ther. and which is not includ. as one of the 12 approved indicat. (eg autism, fibromyalgia), the physician can appeal to the MOH Committee for Med. Cannabis to ask for approval on an individ. exception. basis.
    C/I: Prior, current/ family history (1st degr. relative) of psychos. or schizophr. or schizoaffective disord., a hist. of addict. or substance abuse (include. cannabis use disord.or addict. to alcohol), use in preg.or lact., use in pts. <18 yrs. old, bipol.disord., hypersens. to cannabis, coconut oil, palm kernel oil.
    In pts. with hepat. cancer, it is recommend. not to use med. cannab. that contains THC.
    See lit.

    Neopharm Cure
    partial basket chart

    Benzodiazepine. Midazolam (as HCl) 2.5, 5, 7.5, 10 mg.
    PREFILLED SYRINGE (oromuc. sol.): 4 x
    2.5 mg, 5 mg, 7.5 mg, 10 mg.
    3 - 6 mnths hospital set.: 2.5mg; > 6
    mnths to < 1 yr: 2.5mg; 1 yr to < 5 yrs: 5 mg; 5 yrs to < 10 yrs: 7.5 mg; 10 yrs to <
    18 yrs: 10 mg. See lit.
    Tmt of prolong., acute, convuls. seizures in
    infants, toddlers, children & adolesc. (from
    3 mnths to < 18 yrs). It must only be used
    by parents/carers where the pt has been
    diagnosed to have epilepsy. For infants 3-6
    mnths of age, tmt should be in a hospital
    setting where monitoring is possible and
    resuscitation equipment is available.
    C/I: Hypersens. to the product or other
    BZD; Myasth. gravis; Sev. respir. insuff.;
    Sleep apnoea syndr.; Sev. hepatic impair.

    full basket chart

    Benzodiazepine. Clonazepam 0.5 mg, 2 mg.
    TABS: 30 x 0.5 mg, 2 mg. Initial: 0.25 mg
    2 x dly. Incr. to 1 mg dly aft. 3 days.
    Some pts. may benefit to max. 4 mg
    dly. Not for pts. under 18 yrs. See lit.
    Typical or atypical petit mal, Lenox
    Gastaut syndr. (Petit mal variant),
    generalized prim. or second. tonic-clonic
    seizures incl. grand mal and focal
    seizures, panic disord. with/without
    C/I: Sens. to benzodiazepines, liver dis.,
    acute narrow angle glaucoma, 1st.
    trimest. pregn.

    full basket chart

    Anticonvulsant. Sodium Valproate 200 mg, 500 mg.
    E.C. TABS: 40 x 200 mg, 500 mg.
    SOLN: 50 ml x 200 mg/ml.
    SYR: 110 ml x 200 mg/5 ml. Initial:
    10-15 mg/kg bdy. wt. dly. incr. at 5
    days or 1 wk. intervals by 5 mg/kg bdy.
    wt. dly. Elderly: 15 mg/kg dly. Adults:
    20 mg/kg dly. Child. and Inf: 25 mg/kg
    dly. To be assessed aft. 2-3 wks. ther.
    See lit.
    All forms of epilepsy (grand, petit, mixed
    or partial), porphyria.

    Depalept Chrono
    full basket chart
    Multiple ingredients
    Depalept Chrono

    Anti-Epileptic, Anticonvulsant. Sodium Valproate 333 mg, Valproic Acid 145 mg.
    P.R. TABS: 30. The Init. dly. dosage is usually 10-15 mg/kg, after which doses are incr. up to the optim. dose.
    The mean dosage is 20-30 mg/kg/d. However, if seizures are not brought under control at this dosage it may be incr. and pts. must be closely monitor.
    In child., usually 30 mg/kg/d.
    In adults, usually 20 to 30 mg/kg/d.
    In elderly pts., the dosage should be determ. based on the control of seizur. Tmt. and preven. of manic episodes in the context of bipolar disord.: The recomm. init. dose is 1000 mg/d. The dose should be incr. as fast as possible to the low. dose that brings about the desired clinic. effect. The recomm. mainten. dose for the tmt. of bipolar disord. is between 1000 mg & 2000 mg dly. In except. cases the dose may be incr. to a max. of 3000 mg dly. Dosage should be adjust. individ. See lit.
    Epilepsy: Tmt. of general./partial epilep. second. epilep. and mixed forms of epilep.
    Bipolar disord.: Tmt. and/or prevent. of acute manic episodes in the context of bipolar disord.
    C/I: History of hypersens. to valproate, divalproate, valpromide. Acute hepatit. Chron. hepatit. Hep. porphyria. Person./famil. history of sev. hepatit., in particular drug-related.
    Comb. use with mefloquine and St.-John`s-wort. Pts. known to have mitochond. disord. caused by mutations in the nuclear gene encod. mitochond. enzyme polymerase γ (POLG, e.g. Alpers-Huttenlocher Syndr.). Pts. with known urea cycle disord.

    Dilantin 125
    full basket chart
    Dilantin 125

    Anticonvulsant. Phenytoin Sodium 125 mg/5 ml.
    SUSP: 8 oz. 1 teasp. 3 x dly. (to be
    adjust. to individ. req.).
    Grand mal, psychomotor seizures.

    Other therapeutic systems under Central Nervous System