Antiepileptics

4 Drugs classified under this drug class

Antiepileptics. Brivaracetam 10 mg/ml.
GLASS BOTTLE (oral sol.): 300ml × 10 mg/ml.
Adult.: 50 mg/d or 100 mg/d based on physician assessm. of required seizure reduct. versus potential side effects. The dose should be admin. in two equally divided doses, once in the morn. and once in the even. Based on individ. pt. response and tolerab., the dose may be adjust. in the dose range of 50 mg/d to 200 mg/d.
Missed doses: If pts. missed one dose or more, it is recomm. that they take a single dose as soon as they remember and take the follow. dose at the usual morn. or even. time. This may avoid the brivaracetam plasma concentr. falling below the efficacy level and prevent breakthrough seizures from occur.
Discont.: If brivaracetam has to be discont. it is recomm. to withdraw it gradually by 50 mg/d. on a wkly. basis. After 1 wk. of tmt. at 50 mg/d, a final wk. of tmt. at the dose of 20 mg/d is recomm.
Paediatric population: The physician should prescribe the most appropr. formulation and strength according to wt. and dose. It is recomm. to parent and care giver to admin. Oral sol. with the measure. device (10 ml or 5 ml oral dosing syr.) provided in the carton box.
Child. (≥4 yrs.) and adolesc .≥50 kg: Admin. in 2 equally divided doses: Therap. dose range 50-200 mg/day, Recomm. starting dose 50 mg/d (or 100 mg/d based on physician assessment of need for seizure control). Recomm. mainten. dose- 100 mg/d.
Child. (≥4 yrs.) & adolesc. <50 kg: Admin. in 2 equally divided doses: Therap. dose range 1-4 mg/kg/d.
Recomm. start. dose 1 mg/kg/d (or 2 mg/kg/d) (or 100 mg/d based on physician assessment of need for seizure control).  Recomm. mainten. dose 2 mg/kg/d.
The dose per intake for each pt. should be calculated using the following formula: Volume per admin. (ml) = [wt.(kg) x dly. dose (mg/kg/d)]×0.05. See lit.
Indicated as adjunct. ther. in the tmt. of partial-onset seizur. with/without second. generalisation in adults, adolesc. and child. from 4 yrs. of age with epilepsy.
C/I: Hypersens. Hypersens. to pyrrolidone derivat.

Antiepileptics. Brivaracetam 10 mg/ml.
VIALS: 10 × 5 mg/5 ml. Adult.: 50 mg/d or 100 mg/d based on physician assessm. of required seizure reduct. versus potential side effects. The dose should be admin. in two equally divided doses, once in the morn. and once in the even. Based on individ. pt. response and tolerab., the dose may be adjust. in the dose range of 50 mg/d to 200 mg/d.
Missed doses: If pts. missed one dose or more, it is recomm. that they take a single dose as soon as they remember and take the follow. dose at the usual morn. or even. time. This may avoid the brivaracetam plasma concentr. falling below the efficacy level and prevent breakthrough seizures from occur.
Discont.: If brivaracetam has to be discont. it is recomm. to withdraw it gradually by 50 mg/d. on a wkly. basis. After 1 wk. of tmt. at 50 mg/d, a final wk. of tmt. at the dose of 20 mg/d is recomm.
Paediatric population: The physician should prescribe the most appropr. formulation and strength according to wt. and dose. It is recomm. to parent and care giver to admin. Oral sol. with the measure. device (10 ml or 5 ml oral dosing syr.) provided in the carton box.
Child. (≥4 yrs.) and adolesc .≥50 kg: Admin. in 2 equally divided doses: Therap. dose range 50-200 mg/day, Recomm. starting dose 50 mg/d (or 100 mg/d based on physician assessment of need for seizure control). Recomm. mainten. dose- 100 mg/d.
Child. (≥4 yrs.) & adolesc. <50 kg: Admin. in 2 equally divided doses: Therap. dose range 1-4 mg/kg/d.
Recomm. start. dose 1 mg/kg/d (or 2 mg/kg/d) (or 100 mg/d based on physician assessment of need for seizure control).  Recomm. mainten. dose 2 mg/kg/d.
The dose per intake for each pt. should be calculated using the following formula: Volume per admin. (ml) = [wt.(kg) x dly. dose (mg/kg/d)]×0.05. See lit.
Indicated as adjunct. ther. in the tmt. of partial-onset seizur. with/without second. generalisation in adults, adolesc. and child. from 4 yrs. of age with epilepsy.
C/I: Hypersens. Hypersens. to pyrrolidone derivat.

Antiepileptics. Brivaracetam 10, 25, 50, 75, 100 mg.
F.C. TABS.: 14×10 mg, 56×25 mg, 56×50 mg, 56×100 mg. Adult.: 50 mg/d or 100 mg/d based on physician assessm. of required seizure reduct. versus potential side effects. The dose should be admin. in two equally divided doses, once in the morn. and once in the even. Based on individ. pt. response and tolerab., the dose may be adjust. in the dose range of 50 mg/d to 200 mg/d.
Missed doses: If pts. missed one dose or more, it is recomm. that they take a single dose as soon as they remember and take the follow. dose at the usual morn. or even. time. This may avoid the brivaracetam plasma concentr. falling below the efficacy level and prevent breakthrough seizures from occur.
Discont.: If brivaracetam has to be discont. it is recomm. to withdraw it gradually by 50 mg/d. on a wkly. basis. After 1 wk. of tmt. at 50 mg/d, a final wk. of tmt. at the dose of 20 mg/d is recomm.
Paediatric population: The physician should prescribe the most appropr. formulation and strength according to wt. and dose. It is recomm. to parent and care giver to admin. Oral sol. with the measure. device (10 ml or 5 ml oral dosing syr.) provided in the carton box.
Child. (≥4 yrs.) and adolesc .≥50 kg: Admin. in 2 equally divided doses: Therap. dose range 50-200 mg/day, Recomm. starting dose 50 mg/d (or 100 mg/d based on physician assessment of need for seizure control). Recomm. mainten. dose- 100 mg/d.
Child. (≥4 yrs.) & adolesc. <50 kg: Admin. in 2 equally divided doses: Therap. dose range 1-4 mg/kg/d.
Recomm. start. dose 1 mg/kg/d (or 2 mg/kg/d) (or 100 mg/d based on physician assessment of need for seizure control).  Recomm. mainten. dose 2 mg/kg/d.
The dose per intake for each pt. should be calculated using the following formula: Volume per admin. (ml) = [wt.(kg) x dly. dose (mg/kg/d)]×0.05. See lit.
Indicated as adjunct. ther. in the tmt. of partial-onset seizur. with/without second. generalisation in adults, adolesc. and child. from 4 yrs. of age with epilepsy.
C/I: Hypersens. Hypersens. to pyrrolidone derivat.

Antiepileptics. Cenobamate 12.5 mg, 25 mg, 50 mg, 100 mg, 200 mg.
TABS + FC TABS. (combined pack): 12.5 mg X 14 + 25 mg X 14
FC TABS: 50/100/200 mg X 30
Adlts: recomm. start. dose is 12.5 mg /d, titr. grad. to the recomm. target dose of 200 mg/d. Based on clin. response, dose may be incr. to a max of 400 mg/d. See lit. for recommen. titrat. sched. which should not be exceeded because of  potent. ser. adv. reactions.
For the adjunctive tmt. of focal-onset seizures with or w/o sec. generalisation in adlt. ptts. with epilepsy who have not been adeq. controlled despite tmt. with at least 2 anti-epil. medic. prod.
C/I: Hypersens. Familial Short-QT syndr.
See lit