All the Therapeutic System Drugs
Tocolytic Agent. Atosiban 7.5 mg/ml. Sol. FOR INJECT: 1
CONC. FOR INFUSION: 1
To start as soon as possible aft. diagn.
of preterm labour in 3 successive
stages: initial bolus dose (6.75 mg)
with 7.5 mg/ml sol. for inject., immed.
foll. by continuous high dose infus.
(300 μg/min) during 3 hrs. foll. by
lower dose (100 μg/min) for up to 45
hrs. Infus. to be performed with 7.5
mg/ml conc. sol. for infus. Tmt. not to
exceed 48 hrs. Total dose not to exceed
330 mg active substance.
To delay imminent pre-term birth in
pregn. women with reg. uterine
contracts. of at least 30 secs. durat. at
rate of ≥ 4/30 mins., cervical dilat. of 1-3
cm (multiparas: 0-3), effacement of ≥
50%; age ≥ 18 yrs., gestat. age: 24-33
completed wks; normal fetal heart rate.
C/I: Gestat. age below 24 or over 33
completed wks., prem. rupture
membranes > 30 wks gestat.,
intrauterine growth retard, abnorm.
fetal heart rate, antepartum uterine
hemorrh. req. immed. delivery,
eclampsia and severe pre-eclampsia
req. delivery, intrauterine fetal death,
suspect. intrauterine infect., placenta previa, abruptio placenta, any other cond. of mother and fetus which is
hazardous, known hypersens. to excips.
Antiprogestin. Mifepristone 200 mg. TABS: 3. 3 tabs (600 mg) in single oral
dose, foll. 36-48 hrs later by
misoprostol 400 μg orally.
Medical alt. to surg. terminat. intrauterine
pregn., up to 49 days of
amenorrh. (7 wks), in sequent. use with
prostaglandin analog (misoprostol).
Soft. and dilatat. cervix uteri prior to
surg. terminat. pregn. during 1st
trimester. Prep. action prostaglandin
analogs in terminat. pregn. aft. 1st
Only approved for use in hospitals/
registered medical centers having
approval to undertake terminations of
Oxytocic Agent. Oxytocin 10 IU/ml. AMPS: 10 x 1 ml. See lit.
Induct. labour for medical reasons,
stimulat. labour in hypoton. uterine inertia, during cesar. sect. foll. delivery,
prevent. tmt. post. partum uterine atony
and hemorrh., early stages pregn. as
adjunct. ther. for manage. incomplete,
inevitable or missed abort.
C/I: Hypersens. See lit.
Prostaglandin. Dinoprostone 1 mg / 3 g. VAG. GEL: 3 g x 1 mg, 2 mg. Initial: 1 mg. The pt. should remain in supine pos. for at least 30 min. Aft 6 hrs: A second dose of 1 mg or 2 mg, if necessary.
Therapeutic termination of pregnancy, missed abortion.
C/I: Hypersens. Pts. with hypersens. to prostaglandins. Pts. in whom oxytocic drugs are generally contra-indicated or where prolong. contractions of the uterus are consid. inappropriate such as: Cases with a history of Caesarean sec. or major uterin. surg.; Cases where there is evidence of a potent. for obstruct. labour.
In pts. with a past history of, or existing, pelvic inflamm. dis., unless adequate prior tmt. has been instituted.
Pts. with active cardiac, pulmon., renal or hep.dis.