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    9 Drugs classified under this therapeutic system


    All the Therapeutic System Drugs

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    Atosiban
    Ferring Pharmaceuticals
    RX
    not in the basket chart
    Atosiban

    Tocolytic Agent. Atosiban 7.5 mg/ml.
    Sol. FOR INJECT: 1
    CONC. FOR INFUSION: 1
    To start as soon as possible aft. diagn.
    of preterm labour in 3 successive
    stages: initial bolus dose (6.75 mg)
    with 7.5 mg/ml sol. for inject., immed.
    foll. by continuous high dose infus.
    (300 μg/min) during 3 hrs. foll. by
    lower dose (100 μg/min) for up to 45
    hrs. Infus. to be performed with 7.5
    mg/ml conc. sol. for infus. Tmt. not to
    exceed 48 hrs. Total dose not to exceed
    330 mg active substance.
    To delay imminent pre-term birth in
    pregn. women with reg. uterine
    contracts. of at least 30 secs. durat. at
    rate of ≥ 4/30 mins., cervical dilat. of 1-3
    cm (multiparas: 0-3), effacement of ≥
    50%; age ≥ 18 yrs., gestat. age: 24-33
    completed wks; normal fetal heart rate.
    C/I: Gestat. age below 24 or over 33
    completed wks., prem. rupture
    membranes > 30 wks gestat.,
    intrauterine growth retard, abnorm.
    fetal heart rate, antepartum uterine
    hemorrh. req. immed. delivery,
    eclampsia and severe pre-eclampsia
    req. delivery, intrauterine fetal death,
    suspect. intrauterine infect., placenta previa, abruptio placenta, any other cond. of mother and fetus which is
    hazardous, known hypersens. to excips.

    Gestone
    Ferring Pharmaceuticals
    RX
    full basket chart
    Gestone

    Progestogen. Progesterone 50 mg/ml.
    AMPS: 10 x 1 ml x 50 mg. 5-10 mg I.M.
    dly. for 5-10 days until 2 days bef.
    expect. menstruation.
    Dysfunct. uterine bleed., selected cases as
    add. tmt. infertil. such as IVF, Gift.

    Mifegyne
    Lapidot
    RX
    partial basket chart
    Mifegyne

    Antiprogestin. Mifepristone 200 mg.
    TABS: 3. 3 tabs (600 mg) in single oral
    dose, foll. 36-48 hrs later by
    misoprostol 400 μg orally.
    Medical alt. to surg. terminat. intrauterine
    pregn., up to 49 days of
    amenorrh. (7 wks), in sequent. use with
    prostaglandin analog (misoprostol).
    Soft. and dilatat. cervix uteri prior to
    surg. terminat. pregn. during 1st
    trimester. Prep. action prostaglandin
    analogs in terminat. pregn. aft. 1st
    trimester.
    Only approved for use in hospitals/
    registered medical centers having
    approval to undertake terminations of
    pregnancies.

    Oxytocin Injection BP 10 IU/ml
    Pharmalogic
    RX
    not in the basket chart
    Oxytocin Injection BP 10 IU/ml

    Oxytocic Agent. Oxytocin 10 IU/ml.
    AMPS: 10 x 1 ml. See lit.
    Induct. labour for medical reasons,
    stimulat. labour in hypoton. uterine inertia, during cesar. sect. foll. delivery,
    prevent. tmt. post. partum uterine atony
    and hemorrh., early stages pregn. as
    adjunct. ther. for manage. incomplete,
    inevitable or missed abort.
    C/I: Hypersens. See lit.

    Prostin E2 – Sterile Solution
    Pfizer
    RX
    partial basket chart
    Prostin E2 – Sterile Solution

    Prostaglandin. Dinoprostone 10 mg/ml.
    AMPS: 1 x 0.5 ml (alcohol. sol.). Extraamniot.
    use for ther. term. pregn. (100
    μg/ml). Adapt. to pt. response. Prepare
    sol. cont. 100 μg/ml using diluent
    provided. Subseq. instils. vary 1
    ml-2ml (usually 2 ml) accord. uterine
    response. 2 hrs to elapse betw. instils.
    (Never less than 1 hr). Max. cont.
    admin: Not more than 2 days.
    Ther. abort. 1st/2nd trimester; evac.
    uterus missed abort; alt. to complete
    ther. terminat. when intra-amniot. saline
    injects. failed. Extra-amniot. route more
    effect. and better tolerat. than I.V. route.
    C/I: Hypersens., not to use extra-amniot.
    route in cervicitis/vag. infects. Pts
    already receiv. I.V. oxytocic drugs.

    Prostin E2 – Vaginal Gel
    Pfizer
    RX
    partial basket chart
    Prostin E2 – Vaginal Gel

    Prostaglandin. Dinoprostone 1 mg / 3 g.
    VAG. GEL: 3 g x 1 mg, 2 mg.
    Initial: 1 mg. The pt. should remain in
    supine pos. for at least 30 min. Aft 6
    hrs: A second dose of 1 mg or 2 mg, if
    necessary.
    For labour induct. in term and near term
    pregn. women who have favor. induct.
    features and who have a singleton
    pregn. with vertex present.
    C/I: Hypersens. to prostaglandins or
    other constituents of the gel.
    For pts. in whom oxytocic drugs are
    general. contra-indicated or where
    prolong. contract. of the uterus are
    consid. inappropr. such as:
    Cases with a hist. of Caesarean sect. or
    major uter. Surg.; Cases where there is
    cephalopelvic disproport.; Cases in
    which fetal malpresentat. is present;
    Cases where there is clinical suspic. or
    definite evidence of pre-existing fetal
    distress; Cases in which there is a history
    of difficult labour and/or traumat. deliv.;
    Grand multiparae with over five prev. term pregnan.; Pts. with ruptured
    membran.
    In pts. with a past hist. of, or exist.,
    pelvic inflamm. dis., unless adequate
    prior tmt. has been instituted.
    In pts. where there is clinic. suspic. or
    definite evid. of placenta praevia or
    unexplain. vaginal bleed. during this
    pregn.
    Pts. with active cardiac, pulmonary,
    renal or hepatic dis


    Other therapeutic systems under Obstetrics and Gynecology

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