All the Therapeutic System Drugs
Progestogen. Dydrogesterone 10 mg. TABS: 20, 3x14x10 mg. In comb. with cont. estrogen ther: 1 tab dly for 14 consec. days/28 day cycle.
In comb. with cyclical estrogen ther: 1 tab dly dur. last 12-14 days estrogen ther. If inad. progestational response: 20 mg to be
Progestogen. Norethisterone Acetate 5 mg. TABS: 20. See lit.
Dysfunct. bleed., primary and second.
amenorrh., premenstrual syndr.,
mastopathy, uterine hypoplasia, timing of
C/I: Pregn., severe disturb. liver funct.,
Dubin-Johnson syndr., Rotor syndr.,
past, present liver tumors, history
jaundice, severe prurit., herpes during
pregn., thromboembol. processes
Progestogen. Medroxyprogesterone Acetate 5 mg. TABS.: 100, 24. Endometriosis: Oral MPA 10 mg three times per day for 90 consec. days, begin. on the 1ST d of the menstrual cycle.
Menopaus. Vasomotor Sympt.: Oral MPA 10-20 mg/d given continuous.
Diagn. of prim. and secon. Amenorrhea: Oral MPA 2.5-10 mg/d for 5-10 d.
Tmt. of second. Amenorrhea: Oral MPA 2.5- 10 mg dly. for 5-10 days, for 3 consecut. cycles. In pts. with hypotrophy of the endometrium, estrogens should be used concomit. with MPA ther.
Dysfunctional (Anovulatory) Uterine Bleed.: Oral MPA 2.5 to 10 mg/ d for 5–10 d for 2-3 cycles and then discont. to see if the dysfunct. has regressed. If bleed. occurs from a poorly proliferative endometrium, estrogens should be used concomit. with MPA ther.
Opposition of endometrial effects of estrogen in menopaus. women being treated with estrogen (Hormone Therapy [HT]): For women taking 0.625 mg of conjugated estrogen or an equivalent dly. dose of another estrogen, MPA can be given in one of two regimens:
Continuous regimen of MPA- Oral MPA 2.5 to 5.0 mg dly.
Sequent. regimen of MPA- Oral MPA 5 to 10 mg dly. for 10- 14 consecut. d. of a 28-d or monthly cycle.
Indicated for cases requiring progesterone supplem.
C/I: Hypersens. Known/suspect. preg. Known, past or suspect. breast cancer; Previous idiopathic or current venous thromboembolism (DVT, PE). Active/recent arterial thromboembolic dis. (e.g angina, MI); Acute liver dis., or a history of liver dis. as long as liver funct. tests have failed to return to normal. Porphyria.