All the Therapeutic System Drugs
Bisphosphonate. Zoledronic Acid 5 mg / 100 ml. SOL. FOR INFUS: 1 x 100 ml.
Single I.V. infus. 5 mg x 1 yr. See lit.
Tmt. Paget’s dis. of bone. Tmt. osteoporos.
post-menopaus. women, men at incr. risk
fracture, incl. recent low trauma hip
fracture. Tmt./prevent. glucocorticoidinduc.
osteoporos. Prevent. post
menopaus. osteoporos. in women when
biphosphonate ther. indicat.
C/I: Hypersens. to excips. or any
bisphosphonates, hypocalcem., pregn.,
lact., sev. ren. impair. (CLcr<35 mL/min).
Bisphosphonate. Risedronate Sodium 150 mg. TABS.:1,2,3,4. Tab wkly. to be swallowed whole and not sucked or chewed in an upright position with glass of plain water, at least 30 mins. bef. first food, other medicine or drink (except water) of the day. Pts should not lie down for 30 mins aft. taking tab.
Tmt. of postmenopaus. osteoporosis. Prevent. of postmenopaus. osteoporosis
C/I: Hypersens. Hypocalcaem. Preg., lact.
Severe renal impair.(CrCl <30 ml/min).
Inabil. to stand or sit upright for at least 30 min.
Biphosphonate. Alendronic Acid 70 mg. EFFERVESCENT TABS: 4,12,24. 1 tab (70 mg)×1/week. Missed dose, should be taken one effervescent tab. on the morning after as pt. remembers and return to taking 1 tab (70 mg)×1/week , as original. scheduled on their chosen day.
The tabs. must be taken at least 30 min. before the first food, beverage, or med. product of the day with plain water only. The drug should only be taken upon arising for the day dissolv. in half a glass of plain water (not less than 120 ml or 4.2 fl.oz.). Pts. should not lie down until after their 1st food of the day, which should be at least 30 min. after drinking the oral sol. Pts. should not lie down for at least 30 min. after taking, should not be taken at bedtime or before arising for the day, can be given to pts. who are unable or unwell. to swallow tabs. See lit.
Tmt. of osteoporosis in postmenopaus. women to prevent fractures, include. those of the hip and spine (vertebral compres. fractures).
Tmt. to incr. bone mass in men with osteoporosis.
C/I: Hypersens. Abnormalities of the oesophagus and other factors which delay oesophageal emptying such as stricture or achalasia, Inability to stand or sit upright for at least 30 minutes. Hypocalcaemia.