All the Therapeutic System Drugs
Vasopressin Analog. Desmopressin Acetate 0.1 mg, 0.2 mg. TABS: 30. Central diabetes. insipid:
Initial: Child and adult: 0.1 mg 3 x dly.
Adjust accord. to pt. response. Average
dly dose: 0.2 and 1.2 mg. For most pts,
opt. dose: 0.1-0.2 mg 3 x dly. Nocturn.
enures: Initial: 0.2 mg at bedt., may
incr. to 0.4 mg. Nocturia: 0.1 mg at
bedt. If no effect aft. 1 wk., incr. to 0.2
mg and then to 0.4 mg by wkly
increases. If adeq. medical effect not
achieved within 4 wks, discont.
Central diabetes insip., nocturn. enures.
(in pts from 5 yrs of age with normal abil.
to concentrate urine), symptomat. tmt
noct. in adults assoc. with noct. polyuria.
tmt. must be started bef. age of 65.
C/I: Habit. or psychogen. polydips., SIADH
syndr., known hyponatrem., known or
suspect. card. insuffic./other conds. req.
tmt. with diuretics, mod/severe ren.
insuffic. (creatinine clear. <50 ml/min),
hypersens.
Vasopressin Analog. Desmopressin Acetate 0.1 mg, 0.2 mg. TABS.: 30×0.1, 0.2 mg. Init. dose for child.& adult. is 0.1 mg ×3/d. The dose is than adjust. accord. to the response of the pt. The average dly. dose is btwn. 0.2 - 1.2 mg with tab. admin. For most pts., 0.1 – 0.2 mg ×3/d is the optimal dose regimen.
Nocturn. Enures.: Init. dose is 0.2 mg at bdtme. The dose may be incr. up to 0.4 mg if the lower dose is not sufficien. effective. See lit.
Nocturia: The recom. ded init. dose is 0.1 mg at bdtme. If this does is not sufficien. effective after one wk. it can be incr. to 0.2 mg and then to 0.4 mg by means of wkly. incr. Fluid restrict. is to be enforced. In nocturic pts., a frequency/volume chart should be used to diagnose nocturn. polyuria for at least 2 d. and nights before starting tmt. A night-time urine production excd. the function. bladder capacity or exceed. 1/3 of the 24-hr. urine production is regarded as nocturn. polyuria.
Serum Na+ must be measured before begin. the tmt. and 3 days after initiat. or incr. in dosage and other times during tmt. as seemed necessary by the treat. physician. See lit.
Central diabetes insipidus.
Nocturn. Enures.
Tmt. of nocturia in adults assoc. with nocturne. polyuria.
C/I:
Pts. with Habitual or psychogenic polydipsia (resulting in a urine production exceeding 40 ml/kg/24 hours).
Pts. with syndrome of inappropriate ADH secretion.
Pts. with ith known hyponatraemia.
Pts. with a history of known or suspected cardiac insufficiency and other conditions requiring treatment with diuretics.
Pts. with moder. and sev. ren. insuffic. (CrCl <50 ml/min).
Pts. with hypersens. to desmopressin.
Pts. with pts. over the age of 65 for the tmt. of prim.nocturn. enuresis.
Pts. with pts. over the age of 65 for the tmt. of nocturia.
Before prescrib. Minirin the diagnosis of psychogenic polydipsia and alcohol abuse should be excluded.
