Thyroid and Antithyroid Preparations

7 Drugs classified under this therapeutic system

Thyroid Hormones. Levothyroxine Sodium 50 mcg, 100 mcg.
TABS: 100. Initial: 50-100 μg dly, adjust
by 50 μg at 4-6 wk intervals until
normal metab. maintain. Pts > 50 yrs:
Initial: Max 50 μg dly. Cardiac dis: 25 μg
dly (as 50 μg on alternate days). See lit.
Hypothyroidism, cretinism, juvenile
myxoedema.
C/I: Hypersens., thyrotoxicos.

Thyroid Hormones. Levothyroxine Sodium 50 mcg, 100 mcg.
SCORED TABS: 100 x 50 μg, 100 x 100 μg.
Start with low dose, increase grad.
every 2-4 wks until full replace. dose
reached.
Benign euthyroid goitre, prophylax.
relapse aft. surgery for euthyroid goitre,
hypothyroidism., supp. ther. thyroid
cancer, during anti-thyroid drug tmt.,
diagnost. use, See lit.
C/I: Hypersens., untreated adrenal and/
or pituitary insuffic., untreat.
thyrotoxicos., pregn., acute MI, acute
myocarditis, acute pancarditis, with
antithyroid agent. See lit.

Antithyroid Agent. Methimazole 20 mg.
TABS: 20, 30. 2-3 tabs. dly. up to 5 tabs.
dly. Maint: 1/4-1 tab. dly.
Hyperthyroidism.
C/I: Hypersens. lact.

Anti-Parathyroid Agent. Cinacalcet 30, 60, 90 mg.
F.C. TABS: 14, 28, 84 x 30 mg, 60 mg, 90
mg. With food/shortly aft. meal, whole
and not div. Adults only. Second.
hyperparathyroidism: Initial: 30 mg 1 x
dly. Titrate every 2-4 wks to max. 180
mg 1 x dly. PTH levels to be assessed at
least 12 hrs. aft. dos. See lit.
Parathyroid carcinoma and primary
hyperparathyroidism: Initial: 30 mg 2 x
dly. Titrate every 2-4 wks as foll:
Sequentially: 30 mg 2 x dly; 60 mg 2 x
dly; 90 mg 2 x dly and 90 mg 3-4 x dly
as req. to reduce serum calc. conc. to
below upper limit of normal. Max: 90
mg 4 x dly.
Tmt. second. hyperparathyroidism (HPT)
in end-stage ren. dis. (ESRD) on maint.
dialysis as part of ther. regimen incl.
phosphate binders and/or vit. D steroids
(as appropriate). Reduct. hypercalcem. in
parathyroid carcinoma and primary HPT
for whom parathyroidectomy would be
indicated based on serum calc. levels
(defin. by relev. treat. guide.), but in whom
parathyroidectomy is not clinic. approp. or
is contraind.
C/I: Hypersens.

Antithyroid Agent. Propylthiouracil 50 mg.
TABS: 30. Initial: 300 mg dly. in 3 equal
doses every 8 hrs. Severe cases: 400
mg dly. Maint: 100-150 mg dly. Child
6-10 yrs: Initial: 150-350 mg dly. Maint:
Accord. to pt. response.
Hyperthyroidism, thyrotoxicosis.