Thyroid and Antithyroid Preparations

6 Drugs classified under this therapeutic system

GnRH Agonist. Triptorelin Embonate 22.5 mg.

Thyroid Hormones. Levothyroxine Sodium 50 mcg, 100 mcg.
TABS: 100. Initial: 50-100 μg dly, adjust
by 50 μg at 4-6 wk intervals until
normal metab. maintain. Pts > 50 yrs:
Initial: Max 50 μg dly. Cardiac dis: 25 μg
dly (as 50 μg on alternate days). See lit.
Hypothyroidism, cretinism, juvenile
myxoedema.
C/I: Hypersens., thyrotoxicos.

Thyroid Hormones. Levothyroxine Sodium 25 mcg, 50 mcg, 100 mcg.
SCORED TABS: 100 x 25 μg, 100 x 50 μg, 100 x 100 μg.
Start with low dose, increase grad.
every 2-4 wks until full replace. dose
reached, see lit.
Benign euthyroid goitre, prophylax.
relapse aft. surgery for euthyroid goitre,
hypothyroidism., supp. ther. thyroid
cancer, during anti-thyroid drug tmt.,
diagnost. use, See lit.
C/I: Hypersens., untreated adrenal and/
or pituitary insuffic., untreat.
thyrotoxicos., acute MI, acute
myocarditis, acute pancarditis.
Combination therapy of levothyroxine and an antithyroid agent for hyperthyroidism is not indicated during pregnancy. See lit.

Antithyroid Agent. Methimazole 20 mg.
TABS: 20, 30. 2-3 tabs. dly. up to 5 tabs.
dly. Maint: 1/4-1 tab. dly.
Hyperthyroidism.
C/I: Hypersens. lact.

Antithyroid Agent. Propylthiouracil 50 mg.
TABS: 30. Initial: 300 mg dly. in 3 equal
doses every 8 hrs. Severe cases: 400
mg dly. Maint: 100-150 mg dly. Child
6-10 yrs: Initial: 150-350 mg dly. Maint:
Accord. to pt. response.
Hyperthyroidism, thyrotoxicosis.

Thyroid Hormones. Levothyroxine Sodium 50 mcg, 100 mcg.
TABS: 90. The dose should be adjust.
based on clinic. response & lab. paramet.
Child: 0-3mths. 10-15 mcg/kg/d; 3-6 mths. 8-10 mcg/kg/d; 6-12 mths. 6-8 mcg/kg/d; 1-5 yrs. 5-6 mcg/kg/d; 6-12 yrs. 4-5 mcg/kg/d; over 12 yrs. but growth & puberty incomp. 1.7 mcg/kg/day based on clinic.response & lab.paramet.
Growth & puberty complete 1.7 mcg/
kg/d; Adult: 1.7 mcg/kg/d (100-125 mcg/d for a 70 kg adult).
Hypothyroidism. Pituitary TSH Suppres.
C/I: Hypersens., pts. with untreated
subclin. or overt thyrotoxicosis of any
etiology & pts. with acute MI., pts. with
uncorrect. adren. insuf.