Bisphosphonate

7 Drugs classified under this drug class

Bisphosphonate. Zoledronic Acid 5 mg / 100 ml.
SOL. FOR INFUS: 1 x 100 ml.
Single I.V. infus. 5 mg x 1 yr. See lit.
Tmt. Paget’s dis. of bone. Tmt. osteoporos.
post-menopaus. women, men at incr. risk
fracture, incl. recent low trauma hip
fracture. Tmt./prevent. glucocorticoidinduc.
osteoporos. Prevent. post
menopaus. osteoporos. in women when
biphosphonate ther. indicat.
C/I: Hypersens. to excips. or any
bisphosphonates, hypocalcem., pregn.,
lact., sev. ren. impair. (CLcr<35 mL/min).

Bisphosphonate. Alendronate (as sodium) 70 mg.
TABS: 4. 1 x 70 mg tab 1 x wkly.
Tmt. osteoporos. in postmenopaus.
woman to prevent fractures, incl. hip and
spine.
C/I: Hypersens., esoph. abnorm., inabil.
to stand or sit for at least 30 mins.

Bisphosphonate. Alendronic Acid 70 mg, Cholecalciferol 140 mcg.
TABS: 4. 1 tab 1 x wkly at least 1/2 hr.
bef. first food, beverage or medicat. of
day, with full glass plain water only, to
be swallowed whole, in upright
position. Not to lie down for at least 30
mins. and until after first food.
Tmt. osteoporos. in postmenopaus.
women, to reduce incidence fractures
hip and spine, to incr. bone mass in men
with osteoporos.
C/I: Esophag. abnorms, inability to
stand/sit upright for at least 30 mins.,
hypocalcem., hypersens. See lit.

Bisphosphonate. Alendronate (as sodium) 70 mg.
TABS: 4 x 70 mg. 1 tab 1 x wkly.
Tmt. osteopor. in post-menopaus.
women to prevent fractures, incl. hip,
spine (vertebral compress. fractures).
C/I: Inability to stand or sit upright for at
least 30 mins., hypocalcem., esophagus
abnormal., hypersens. See lit.

Bisphosphonate. Risedronate Sodium 35 mg.
TABS: 4. 1 tab wkly. to be
swallowed whole and not sucked or
chewed in an upright position with
glass of plain water, at least 30 mins.
bef. first food, other medicine or drink
(except water) of the day. Pts should
not lie down for 30 mins aft. taking
tab.
Tmt. postmenopaus. osteoporos:,
established postmenopaus.
osteopor,
prevent. osteopor. in postmenopaus.
women with incr. risk of osteopor. Tmt.
osteopor. in men, at high risk of
fracture.
C/I: Known hypersens., hypocalcem.,
pregn. lact., severe ren. impair.

Bisphosphonate. Risedronate Sodium 150 mg.
Tab. X1
Orally once a month. to be taken
on the same date each month.
Absorption is affected by food and polyvalent cations.
To ensure adequate absorption pts. should take this drug
at least 30 minutes before the first food with tap water and stand or sit upright for at least 30 minutes. See lit.
Treatment of postmenopausal osteoporosis. Prevention of postmenopausal osteoporosis.
C/I:  Abnormalities of the esophagus which delay esophageal emptying such as stricture or achalasia /Inability to stand or sit upright for at least 30 minutes
Hypocalcemia / Hypersensitivity