All the Drug Class Drugs
Angiotensin II Antagonist, Thiazide. Candesartan Cilexetil 16 mg, Hydrochlorothiazide 12.5 mg. TABS: 30. Adults, elderly: 1 tab. 1 x dly
with/out food. Pts. with intravasc. vol.
deplet: Dose titrat. of candesartan
cilexetil is recommend. (init. 4 mg dose of
candesartan cilexetil may be considered).
Impair. ren. funct: Dose titrat. of
candesartan cilexetil is recommend.
when creatinine clear. ≥ 30 ml/min/1.73
m2 BSA (recommend. dose candesartan
cilexetil 4 mg in pts/ with mild-mod. ren.
impair.). Not to be used in pts with severe
ren. impair. creatinine clear. < 30 ml/
min/1.73 m2 BSA). Impair. hepat. funct:
Dose titrat. is recommend. in mild-mod.
impair. (recommend. start. dose is 2 mg).
Not to be used in pts. with severe hep.
impairm./cholestas. Safety, effic. not
estab. in child.
Essent. hypertens. where monother. with
candesartan cilexetil or
hydrochlorothiazide not. suffic.
C/I: Hypersens. to prod./sulfonamide
derived drugs, pregn., lact., severe ren.
impair., severe hepat. impair./cholestas.,
refractory hypokalem., hypocalcem.,
gout.
ACE Inhibitor, Thiazide. Cilazapril 5 mg, Hydrochlorothiazide 12.5 mg. TABS: 28. 1 tab dly.
Essential hypertens. in patients who
have been stabilized on individual
components given in the same
proportions.
C/I: Pregn., lact.
Angiotensin II Antagonist, Thiazide. Valsartan 80 mg, 160 mg, Hydrochlorothiazide 12.5 mg, 25 mg. CO-DIOVAN 80: F.C. TABS: 28. 1 tab dly. Max. effect within 2-4 wks.
Hypertens. when comb. ther. appropriate.
CO-DIOVAN 160: F.C. TABS: 28. 1 tab dly.
Hypertens., when blood pressure not adequat. controlled by monother. To be used as second-line ther.
C/I: Hypersens. Hypersens. to sulfonamide-derived med. products. 2nd & 3rd trim. of preg. Biliary cirrhos. and cholestasis. Pts. with anuria. Refractor. hypokalaemia, hyponatraemia, hypercalcaemia, and symptomat. hyperuricaemia. Concom. use with aliskiren-contain. products in pts. with diab. mell. or renal impair. (GFR <60 mL/min/1.73m²).
Angiotensin II Antagonist, Thiazide. Hydrochlorothiazide 12.5 mg, Losartan Potassium 50 mg. TABS: 30. Admin. with/out food, may
admin. with other antihypertensives.
Hypertens: Initial: 1 tab 1 x dly. Max: 2
tabs 1 x dly. Effect within 3 wks. No
adjust. elderly pts. Reduct. stroke risk
in hypertens. pts with left ventric.
hypertrophy: Initial: 1 tab 1 x dly. If
goal BP not reached, incr. to 2 tabs 1 x
dly.
Tmt. hypertens., for pts. in whom comb.
ther. is appropr. Reduce risk of stroke in pts.
with hypertens. and left ventric.
hypertrophy.
C/I: Known hypersens., also to
sulfonamide-derivs, pts with anuria,
pregn 2nd, 3rd trimests.
Angiotensin II Antagonist, Thiazide. Hydrochlorothiazide 12.5 mg, Losartan Potassium 50 mg. TABS: 30. 1 tab dly. Max: 2 tabs dly.
May administer with other
antihypertens. agents.
Hypertens. when comb. ther. appropriate.
C/I: Hypersens. to compon., hypersens. to
sulfonamide derived drugs, anuria,
pregn., severe renal impair., intravasc.
deplet.
ACE Inhibitor, Thiazide. Hydrochlorothiazide 12.5 mg, 25 mg, Ramipril 2.5 mg, 5 mg. SCORED TABLETS: 30. Accord. desired
antihypertens. effect and pt’s tol. to the
drug. Initial: 2.5 mg ramipril/12.5 mg
HCT, If necess., dose may incr. at
intervals of 2-3 wks. Max. dly dose: 10
mg ramipril/50 mg HCT. Admin. in
morn. as single dose. In most cases,
blood press. will fall suffic. after 2.5 mg
ramipril/12.5 HCT or 5 mg ramipril/25
mg HCT dly. Pts pre-treated with
diuretics: Discont. diuret. at least 2-3
days bef. start. tmt or at least reduc.
diuret. If discont. imposs., initiate tmt.
with smallest possible dose (1.25 mg)
dly in free combinat. Subsequent.
change to dly dose of max. 2.5 mg
ramipril/ 12.5 mg HCT. Ren. impair. pts:
Creatinine clear. 60-30 ml/min/1.73 m2
body surface: Initial: ramipril alone:
1.25 mg dly. Aft. grad. incr. dose, start
combinat. prep: with 2.5 mg
ramipril/12.5 mg HCT dly. Max dly
dose: 5 mg ramipril/25 mg HCT. Impair.
liver funct: Response to tmt. may be
increased/reduced. Tmt. must
therefore be initiated only under close
medic. vis. Max. dly dose: 2.5 mg. Tabs.
to be swallowed whole with liq.
(approx. 1/2 glass) before/during/after
meal. Not to be chewed or crushed.
Not for child.
Essent. hypertens. when blood press.
cannot be adeq. lowered with ramipril
alone.
C/I: Hypersens. to ramipril, any other ACE
inhib., HCT, other thiazide diuret.,
sulfonamides, any other ingred. of the
prep. History angioneurot. edema;
severe impair. ren. funct; dialysis pts, pts.
with hemodynamic. relevant ren. art.
stenos., bilat./unilat. in the single kidney.
Pts. with hemodynamic. relevant leftventric.
inflow/outflow imped. (e.g.
stenos. aort./mitral valve); pts. with clinic.
relevant electrolyte disturbs. which may
worsen follow. tmt, e.g. hypokalem.,
hyponatrem., hypercalcem., severe
impair. liver funct., pregn., lact., concom.
use ACE inhibit., extracorporeal tmt. lead. to contact of blood with negatively
charged surfaces must be avoided (may
lead to severe anaphylact. react.). Such
tmts incl: dialysis or hemofiltrat. with
certain high-flux membranes and low
density lipoprotein apheres. with
dextran sulfate.
