Lotan Plus

/ Unipharm

See prescribing information for full details.

For the treatment of hypertension, for patients in whom combination therapy is appropriate. To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Hypersensitivity to components, to sulfonamide derived drugs. Anuria, pregnancy, severe renal impairment, intravascular depletion.

Changes in renal function, including renal failure, have been reported; these changes may be reversible upon discontinuation of therapy. A lower dose should be considered for patients with a history of hepatic impairment. In patients who are intravascularly volume-depleted, symptomatic hypotension may occur. These conditions should be corrected prior to administration of therapy, or a lower starting dose should be used. Safety and effectiveness of use in children have not been established. Lactation: A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. See literature for full details.

Adverse experiences have in general been mild and transient and have not required discontinuation of therapy: Abdominal pain, asthenia/fatigue, chest pain, edema, palpitation, tachycardia, diarrhea, dyspepsia, nausea, back pain, muscle cramps, dizziness, headache, insomnia, cough, nasal congestion, pharyngitis, upper respiratory infection. Anaphylactoid reactions, vasculitis, hepatitis, anemia, myalgia, migraine, cough, urticaria, pruritis, heart failure. See literature for full details.

Potassium-sparing diuretics.